INT104905

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Context Info
Confidence 0.08
First Reported 2002
Last Reported 2009
Negated 1
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.08
Pain Relevance 0.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Alpl) plasma membrane (Alpl) cytoplasm (Alpl)
Alpl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 3 98.32 Very High Very High Very High
fibrosis 1 63.48 Quite High
Inflammation 1 37.68 Quite Low
cva 9 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Potency 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
headache 2 5.00 Very Low Very Low Very Low
Osteoarthritis 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 2 98.32 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 1 91.44 High High
Fibrous Dysplasia Of Bone 3 84.60 Quite High
Skin Cancer 1 83.64 Quite High
Polyostotic Fibrous Dysplasia 5 78.68 Quite High
Osteoporosis 16 78.12 Quite High
Endometrial Cancer 7 69.08 Quite High
Fibrosis 1 63.48 Quite High
Postmenopausal Osteoporosis 15 62.16 Quite High
INFLAMMATION 1 37.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There were no significant reported decreases in serum bone-specific alkaline phosphatase (BSAP) with 14 days of lasofoxifene treatment.
Neg (no) Localization (decreases) of serum bone-specific alkaline phosphatase
1) Confidence 0.08 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2773750 Disease Relevance 0.19 Pain Relevance 0.03
In our study, treatment reduced bone pain, fracture rate and metabolic indices of bone turnover, in particular significantly decreased bone alkaline phosphatase and cross-links (Wilcoxon test; p <0.06), and increased bone mineral density (DEXA).
Localization (decreased) of bone alkaline phosphatase associated with pain
2) Confidence 0.06 Published 2002 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 12199352 Disease Relevance 0.88 Pain Relevance 0.10

General Comments

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