INT104906

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.72
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Alpl) plasma membrane (Alpl) cytoplasm (Alpl)
Anatomy Link Frequency
testis 2
Alpl (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 5 98.32 Very High Very High Very High
fibrosis 1 63.48 Quite High
Inflammation 1 37.68 Quite Low
Kinase C 42 5.00 Very Low Very Low Very Low
cva 9 5.00 Very Low Very Low Very Low
Bioavailability 5 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Central nervous system 3 5.00 Very Low Very Low Very Low
Osteoarthritis 3 5.00 Very Low Very Low Very Low
antagonist 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 4 98.32 Very High Very High Very High
Phosphate Metabolism Disorders 4 98.28 Very High Very High Very High
Spontaneous Fractures 1 93.60 High High
Attention Deficit Hyperactivity Disorder 1 91.44 High High
Rickets 2 86.24 High High
Fibrous Dysplasia Of Bone 3 84.60 Quite High
Skin Cancer 1 83.64 Quite High
Polyostotic Fibrous Dysplasia 5 78.68 Quite High
Osteoporosis 16 78.12 Quite High
Injury 1 72.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Hypophosphatasia is an inheritable disorder characterised by defective bone mineralisation due to the impaired activity of tissue-non-specific alkaline phosphatase (AP).
Negative_regulation (impaired) of tissue-non-specific alkaline phosphatase associated with phosphate metabolism disorders
1) Confidence 0.31 Published 2009 Journal Eur. J. Pediatr. Section Abstract Doc Link 18818947 Disease Relevance 0.64 Pain Relevance 0.08
In the present study, the activity of ACP was significantly increased by taurine supplementation in testis of adult and aged rats, but the activity of AKP was obviously decreased in testis of adult rats.
Negative_regulation (decreased) of AKP in testis
2) Confidence 0.24 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
-alanine administration in testis, and the activity of AKP was significantly decreased.
Negative_regulation (decreased) of AKP in testis
3) Confidence 0.17 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
-alanine supplement in adult rats, the levels of AKP, LDH, SDH and GSH were obviously reduced, and the levels of SOD, NOS and NO had no changes.
Negative_regulation (reduced) of AKP
4) Confidence 0.08 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994374 Disease Relevance 0 Pain Relevance 0
1 increased ePPi levels by activating ecto-enzymes and not by reducing TNAP activity, which remained undetectable.


Neg (not) Negative_regulation (reducing) of TNAP
5) Confidence 0.06 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246241 Disease Relevance 0 Pain Relevance 0
In our study, treatment reduced bone pain, fracture rate and metabolic indices of bone turnover, in particular significantly decreased bone alkaline phosphatase and cross-links (Wilcoxon test; p <0.06), and increased bone mineral density (DEXA).
Negative_regulation (decreased) of bone alkaline phosphatase associated with pain
6) Confidence 0.05 Published 2002 Journal J. Pediatr. Endocrinol. Metab. Section Abstract Doc Link 12199352 Disease Relevance 0.88 Pain Relevance 0.10
There were no significant reported decreases in serum bone-specific alkaline phosphatase (BSAP) with 14 days of lasofoxifene treatment.
Neg (no) Negative_regulation (decreases) of serum bone-specific alkaline phosphatase
7) Confidence 0.04 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2773750 Disease Relevance 0.19 Pain Relevance 0.03

General Comments

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