INT104908

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Context Info
Confidence 0.05
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.62
Pain Relevance 0.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (B4GALNT1) plasma membrane (B4GALNT1) carbohydrate metabolic process (B4GALNT1)
Anatomy Link Frequency
hepatocytes 1
lymphocyte 1
B4GALNT1 (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 4 98.68 Very High Very High Very High
Dismenorea 5 98.16 Very High Very High Very High
Inflammation 133 94.60 High High
endometriosis 42 93.64 High High
cytokine 50 88.52 High High
Bioavailability 4 79.52 Quite High
Inflammatory stimuli 1 46.40 Quite Low
Pain 4 38.96 Quite Low
Inflammatory mediators 5 32.64 Quite Low
cINOD 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Hypercalcemia 2 99.80 Very High Very High Very High
Dengue Hemorrhagic Fever 205 99.60 Very High Very High Very High
Endometriosis 6 98.16 Very High Very High Very High
Shock 19 97.08 Very High Very High Very High
Injury 55 95.92 Very High Very High Very High
INFLAMMATION 155 94.60 High High
Endometriosis (extended) 48 93.64 High High
Dengue 88 90.04 High High
Cancer 52 90.00 High High
Stress 216 87.68 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Expressions of endothelial and inducible NO synthase and peroxynitrite generation was markedly reduced after GnRH agonist therapy, supporting their potential role in the pathophysiology of adenomyosis [132].
synthase Neg (NO) Binding (generation) of associated with dismenorea and agonist
1) Confidence 0.05 Published 2005 Journal Reprod Biol Endocrinol Section Body Doc Link PMC1215514 Disease Relevance 0.92 Pain Relevance 0.55
COX, also known as prostaglandin endoperoxide synthase (Pghs) or as prostaglandin G/H synthase, is a key membrane bound enzyme responsible for the oxidation of AA to PGs.
synthase Binding (bound) of
2) Confidence 0.03 Published 2002 Journal Biomed. Pharmacother. Section Abstract Doc Link 12199620 Disease Relevance 0 Pain Relevance 0
It has a higher binding affinity for hydroxyapatite and is a more potent inhibitor of farnesyl disphosphonate synthase and bone resorption than other bisphosphonates.15 ZOL has demonstrated inhibition of bone resorption in vivo at doses of 0.072 ?
synthase Binding (affinity) of associated with hypercalcemia
3) Confidence 0.02 Published 2009 Journal Patient Prefer Adherence Section Body Doc Link PMC2778428 Disease Relevance 0.48 Pain Relevance 0.04
Firstly FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex.
synthase Binding (bound) of
4) Confidence 0.02 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886333 Disease Relevance 0.65 Pain Relevance 0
Firstly FdUMP and the folate cofactor, N5-10-methylenetetrahydrofolate, bind to thymidylate synthase (TS) to form a covalently bound ternary complex.
synthase Binding (bind) of
5) Confidence 0.02 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886333 Disease Relevance 0.65 Pain Relevance 0
In particular, the two potent immunomodulating factors prostaglandin E synthase and VSIG4, which dampen both T and NK lymphocyte responses [43]–[45] and have both a strong statistical association with the DSS phenotype, could have such a negative effect.
synthase Binding (association) of in lymphocyte associated with dengue hemorrhagic fever
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2907396 Disease Relevance 1.63 Pain Relevance 0.14
Three types of NOS have been identified: endothelial NO synthase (eNOS), which is bound to plasma membranes and known to be strongly activated by the entry of calcium through membrane-bound receptors [59]; inducible NO synthase (iNOS), which was first identified in macrophages and then in other cells, including hepatocytes, is known to be up-regulated by pro-inflammatory cytokines and/or lipopolysaccharide (LPS), and is able to generate low levels of NO compared with the other NOS isoforms; and neuronal NO synthase (nNOS) (Figure 4).
NO synthase Binding (bound) of in hepatocytes associated with inflammation and cytokine
7) Confidence 0.01 Published 2008 Journal Fibrogenesis Tissue Repair Section Body Doc Link PMC2584013 Disease Relevance 0.29 Pain Relevance 0.09

General Comments

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