INT104912

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Context Info
Confidence 0.63
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 24
Disease Relevance 4.48
Pain Relevance 1.81

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (Acvr2a)
Anatomy Link Frequency
retina 3
brain 2
skeletal muscle 1
neurons 1
proximal 1
Acvr2a (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Central nervous system 16 98.14 Very High Very High Very High
adenocard 18 96.88 Very High Very High Very High
Action potential 87 95.04 Very High Very High Very High
anesthesia 34 91.96 High High
Enkephalin 8 91.68 High High
GABAergic 4 89.92 High High
sodium channel 1 50.00 Quite Low
addiction 17 45.76 Quite Low
Analgesic 2 10.00 Low Low
antagonist 78 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 401 99.90 Very High Very High Very High
Retina Disease 187 99.64 Very High Very High Very High
Ganglion Cysts 53 99.52 Very High Very High Very High
Sunburn 17 96.68 Very High Very High Very High
Night Blindness 17 76.00 Quite High
Disease 21 66.36 Quite High
Repression 2 24.32 Low Low
Apoptosis 36 11.00 Low Low
Stress 113 5.00 Very Low Very Low Very Low
INFLAMMATION 56 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, expressions of A2A-R and the transgene were found in both neurons and astrocytes, suggesting that adenosine might mediate its function through A2A-R in both cell types.
Gene_expression (expressions) of A2A-R in neurons associated with adenocard
1) Confidence 0.63 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622213 Disease Relevance 0 Pain Relevance 0.38
Collectively, the 4.8-kb promoter-proximal DNA fragment of the rat A2A-R gene contains important element(s) to direct its expression in the CNS where functional A2A-R are found, but were not sufficient to confer the highly concentrated expression of the striatal A2A-R.
Gene_expression (expression) of A2A-R in proximal associated with central nervous system
2) Confidence 0.63 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622213 Disease Relevance 0 Pain Relevance 0.39
METHODS: Whole cell sodium inward currents via heterologously (HEK293 cells) expressed rat neuronal (rat type IIA) and human skeletal muscle (hSkM1) sodium channels were recorded in the absence and presence of definite concentrations of either thymol or menthol.
Gene_expression (expressed) of type IIA in skeletal muscle
3) Confidence 0.59 Published 2002 Journal Eur J Anaesthesiol Section Body Doc Link 12200946 Disease Relevance 0 Pain Relevance 0
Double immunohistochemical analyses revealed that the transgene was coexpressed with endogenous A2A-R and proper neuronal markers in the brain.
Gene_expression (coexpressed) of A2A-R in brain
4) Confidence 0.55 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622213 Disease Relevance 0 Pain Relevance 0.38
Furthermore, expressions of A2A-R and the transgene were found in both neurons and astrocytes, suggesting that adenosine might mediate its function through A2A-R in both cell types.
Gene_expression (expressions) of A2A-R in astrocytes associated with adenocard
5) Confidence 0.22 Published 2003 Journal Eur. J. Neurosci. Section Abstract Doc Link 14622213 Disease Relevance 0 Pain Relevance 0.38
Similarly, in castrated mice in which the gene for activin receptor type II (Act-R-II) was disrupted, FSH?
Gene_expression (gene) of Act-R-II
6) Confidence 0.16 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
Similarly, in castrated mice in which the gene for activin receptor type II (Act-R-II) was disrupted, FSH?
Gene_expression (gene) of activin receptor type II
7) Confidence 0.16 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0
In the present study, we established several lines of transgenic rats in which ChR2 expression was driven by the Thy-1.2 promoter.
Gene_expression (expression) of ChR2 associated with targeted disruption
8) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.29 Pain Relevance 0.03
Transgenic rats that express ChR2 in RGCs provide a useful experimental model with which to evaluate quantitatively the visual function of an animal in which RGCs are made photosensitive by the expression of ChR2.
Gene_expression (expression) of ChR2 associated with targeted disruption
9) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.16 Pain Relevance 0
One of our lines, W-TChR2V4, expressed ChR2 nearly selectively in RGCs.
Gene_expression (expressed) of ChR2
10) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.15 Pain Relevance 0
We investigated this by using a line of transgenic rats, W-TChR2V4, in which the ChR2 gene was expressed selectively in RGCs under the regulation of the Thy-1.2 promoter.
Gene_expression (expressed) of ChR2 associated with targeted disruption
11) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.27 Pain Relevance 0.04
Transgenic rats that express ChR2 in RGCs provide a useful experimental model with which to evaluate quantitatively the visual function of an animal in which RGCs are made photosensitive by the expression of ChR2.
Gene_expression (express) of ChR2 associated with targeted disruption
12) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.26 Pain Relevance 0
The phenotypic expression of ChR2 was detected in the retina by the coexpression of the fluorescent protein “Venus,” which is connected at the C-terminal end of the N-terminal 315 amino acid fragment of ChR2.
Gene_expression (expression) of ChR2 in retina
13) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.27 Pain Relevance 0.03
Since the transfer of the ChR2 gene into RGCs was not regulated according to RGC type in these studies, it is possible that all RGC types became photosensitive.
Gene_expression (transfer) of ChR2
14) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.32 Pain Relevance 0
In some lines such as W-TChR2V1, W-TChR2V5, and W-TChR2V6, ChR2 was expressed in nonganglion cells such as amacrine, bipolar, and Müller.
Gene_expression (expressed) of ChR2
15) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.21 Pain Relevance 0.03
In addition, Bi et al. reported that the transfer of ChR2 restored visually evoked cortical responses in blind mice [8].
Gene_expression (transfer) of ChR2
16) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.51 Pain Relevance 0
In heterozygous rats where ChR2 was conjugated with a fluorescent marker, ChR2 was exclusively expressed in the RGCs.
Gene_expression (expressed) of ChR2
17) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.27 Pain Relevance 0.05
For the examination of the expression of ChR2-Venus in the retina, a few rats of each positive line were perfused with a fixative solution containing 4% paraformaldehyde and 15% saturated picric acid in 0.1 M phosphate buffer (pH 7.2) under deep anesthesia.
Gene_expression (expression) of ChR2 in retina associated with anesthesia
18) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.16 Pain Relevance 0.09
Therefore, this line appeared to be the most suitable line for studying visual function produced by ChR2-transferred RGCs.
Gene_expression (produced) of ChR2
19) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.14 Pain Relevance 0
One of them, line 4 (W-TChR2V4), expressed ChR2 specifically in the RGCs of the entire retina.
Gene_expression (expressed) of ChR2 in retina
20) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2772120 Disease Relevance 0.23 Pain Relevance 0

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