INT104929

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Context Info
Confidence 0.46
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 6.66
Pain Relevance 1.76

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (TNFRSF10B)
Anatomy Link Frequency
colon 2
chondrocyte 1
TNFRSF10B (Homo sapiens)
Pain Link Frequency Relevance Heat
cINOD 14 99.38 Very High Very High Very High
spinal inflammation 4 97.64 Very High Very High Very High
cytokine 15 92.20 High High
rheumatoid arthritis 35 88.64 High High
Paracetamol 1 86.12 High High
Inflammation 69 79.60 Quite High
Snapping jaw 2 75.00 Quite High
cva 1 55.28 Quite High
agonist 2 35.52 Quite Low
Pain 4 30.80 Quite Low
Disease Link Frequency Relevance Heat
Death 36 100.00 Very High Very High Very High
Apoptosis 249 99.92 Very High Very High Very High
Colon Cancer 6 97.64 Very High Very High Very High
Low Back Pain 4 97.64 Very High Very High Very High
INFLAMMATION 71 90.48 High High
Necrosis 10 89.92 High High
Cancer 23 89.56 High High
Rheumatoid Arthritis 75 88.64 High High
Metaplasia 1 83.12 Quite High
Diabetes Mellitus 83 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here we report that two different NSAIDs, sulindac sulfide and SC-'236 engage the death receptor 5 (DR5) and mitochondrial pathways to mediate apoptosis in human colon cancer cells.
DR5 Binding (engage) of in colon associated with colon cancer, cinod, apoptosis and death
1) Confidence 0.46 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 0.95 Pain Relevance 0.45
Here we report that two different NSAIDs, sulindac sulfide and SC-'236 engage the death receptor 5 (DR5) and mitochondrial pathways to mediate apoptosis in human colon cancer cells.
death receptor 5 Binding (engage) of in colon associated with colon cancer, cinod, apoptosis and death
2) Confidence 0.46 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 0.95 Pain Relevance 0.45
OBJECTIVE: To investigate the association of killer cell immunoglobulin-like receptors (KIR) genotype and haplotype with ankylosing spondylitis (AS).
killer Binding (association) of associated with spinal inflammation
3) Confidence 0.36 Published 2009 Journal Zhonghua Yi Xue Za Zhi Section Abstract Doc Link 19489269 Disease Relevance 0.17 Pain Relevance 0.17
Overexpression of DR5 receptor and its ligand (TRAIL) in chondrocyte-like cells suggested activation of programmed cell death, as also demonstrated by TUNEL-positive cells.
DR5 receptor Binding (ligand) of in chondrocyte associated with apoptosis
4) Confidence 0.26 Published 2009 Journal Histol. Histopathol. Section Abstract Doc Link 19130398 Disease Relevance 0.66 Pain Relevance 0.15
The receptor binds to DR3, DR4, DR5, ER6 and ER8 motifs of the general nuclear receptor binding site, which have been identified in enhancer and promoter regions of some of the genes regulated [reviewed in [1]].
DR5 Binding (binds) of
5) Confidence 0.24 Published 2004 Journal Nucl Recept Section Body Doc Link PMC406421 Disease Relevance 0 Pain Relevance 0.09
Therefore, recruitment to the HRE and activation of DR3- and DR5-dependent transcription by this factor does not involve a direct association with the receptors and appears to require DREAM–DNA interactions.
DR5 Binding (recruitment) of
6) Confidence 0.19 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
This situation is similar to that found with the RXR/RAR heterodimer bound to a DR1 (43), or the RXR/VDR heterodimer bound to a DR5 (44), which cannot trigger transcriptional activation through these elements.
DR5 Binding (bound) of
7) Confidence 0.17 Published 2005 Journal Nucleic Acids Research Section Body Doc Link PMC1084319 Disease Relevance 0 Pain Relevance 0
TRAIL induces apoptosis by binding and cross-linking the death-domain containing receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) [3].
DR5 Binding (binding) of associated with apoptosis and death
8) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.15 Pain Relevance 0.17
TRAIL induces apoptosis by binding and cross-linking the death-domain containing receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) [3].
DR5 Binding (cross) of associated with apoptosis and death
9) Confidence 0.15 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.15 Pain Relevance 0.17
When TRAIL binds TRAIL-R1 (DR4) and TRAIL-R2 (DR5) apoptotic signals are transduced.
DR5 Binding (binds) of associated with apoptosis
10) Confidence 0.12 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.63 Pain Relevance 0.11

General Comments

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