INT104930

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Context Info
Confidence 0.86
First Reported 2002
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 12
Total Number 12
Disease Relevance 10.82
Pain Relevance 3.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (BID) mitochondrion (BID) cytoplasm (BID)
Anatomy Link Frequency
cleavage 11
HL-60 1
BID (Homo sapiens)
Pain Link Frequency Relevance Heat
qutenza 28 99.60 Very High Very High Very High
diclofenac 18 97.56 Very High Very High Very High
cINOD 23 90.80 High High
cytokine 28 81.36 Quite High
Inflammation 22 75.00 Quite High
antagonist 48 47.16 Quite Low
chemokine 3 40.80 Quite Low
agonist 56 34.64 Quite Low
COX2 1 25.00 Low Low
COX-2 inhibitor 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 280 99.84 Very High Very High Very High
Apoptosis 469 99.40 Very High Very High Very High
Death 96 98.04 Very High Very High Very High
Colon Cancer 68 94.80 High High
Stress 23 87.36 High High
INFLAMMATION 27 81.16 Quite High
Necrosis 7 75.96 Quite High
Leukemia 18 75.00 Quite High
Toxicity 9 71.60 Quite High
Uremia 1 62.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.
Protein_catabolism (cleavage) of Bid in cleavage associated with qutenza
1) Confidence 0.86 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 1.08 Pain Relevance 0.75
We show that sulindac sulfide and SC-'236-induced apoptosis is coupled with upregulation of DR5, caspase 8 activation and Bid cleavage.
Protein_catabolism (cleavage) of Bid in cleavage associated with apoptosis
2) Confidence 0.64 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 1.01 Pain Relevance 0.46
Capsaicin-induced caspase-9, Bid cleavage, and AIF translocation were blocked by calpeptin, and BAPTA and calpeptin attenuated calpain activation and Bid cleavage.
Protein_catabolism (cleavage) of Bid in cleavage associated with qutenza
3) Confidence 0.64 Published 2009 Journal Toxicology Section Abstract Doc Link 19699254 Disease Relevance 0.93 Pain Relevance 0.68
Ac-IETD-CHO, a caspase-8 inhibitor, suppresses Bid cleavage and DNA fragmentation. z-VAD-fmk, a universal caspase inhibitor, but not cyclosporin A (CsA), an inhibitor of mitochondrial membrane permeability transition, suppresses DNA fragmentation.
Protein_catabolism (cleavage) of Bid in cleavage
4) Confidence 0.52 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451068 Disease Relevance 0.52 Pain Relevance 0.39
These results suggest the sequential mechanism of diclofenac-induced apoptosis of HL-60 cells: ROS generation suppresses Akt activity, thereby activating caspase-8, which stimulates Bid cleavage and induces cytochrome c release and the activation of caspase-9 and-3 in a CsA-insensitive mechanism.
Protein_catabolism (cleavage) of Bid in HL-60 associated with apoptosis and diclofenac
5) Confidence 0.52 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451068 Disease Relevance 0.48 Pain Relevance 0.39
Cyclic AMP, an inducer of Akt phosphorylation, suppresses Akt inactivation, Bid cleavage, and DNA fragmentation.
Protein_catabolism (cleavage) of Bid in cleavage
6) Confidence 0.45 Published 2004 Journal Free Radic. Biol. Med. Section Abstract Doc Link 15451068 Disease Relevance 0.53 Pain Relevance 0.38
This finding therefore indicates that Ocimum gratissimum extract does not attenuate caspase-8 activation but may modulate the cleavage of Bid and alleviate apoptosis through other mechanisms.
Protein_catabolism (cleavage) of Bid in cleavage associated with apoptosis
7) Confidence 0.34 Published 2011 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Body Doc Link PMC2952314 Disease Relevance 0.50 Pain Relevance 0
In type I cells, caspase-8 activation is sufficient to activate effector caspases 3, 6 and 7, while in type II cells, the apoptotic cascade requires integration of the mitochondrial pathway mediated by caspase-8 induced cleavage of Bid.
Protein_catabolism (cleavage) of Bid in cleavage associated with apoptosis
8) Confidence 0.28 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.52 Pain Relevance 0
On the other hand, caspase-8 can induce Bid cleavage.
Protein_catabolism (cleavage) of Bid in cleavage
9) Confidence 0.22 Published 2009 Journal Mol Biol Rep Section Body Doc Link PMC2941086 Disease Relevance 1.32 Pain Relevance 0.03
Leptin delayed the cleavage of Bid and Bax, the mitochondrial release of cytochrome c and second mitochondria-derived activator of caspase, as well as the activation of both caspase-8 and caspase-3 in these cells [42].
Protein_catabolism (cleavage) of Bid in cleavage
10) Confidence 0.20 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2846344 Disease Relevance 0.23 Pain Relevance 0.07
caspase-8-mediated cleavage of Bid, which facilitates Bax activation and
Protein_catabolism (cleavage) of Bid in cleavage
11) Confidence 0.19 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.31 Pain Relevance 0
Thus, the Bid cleavage
Protein_catabolism (cleavage) of Bid in cleavage
12) Confidence 0.16 Published 2008 Journal PPAR Research Section Body Doc Link PMC2442903 Disease Relevance 1.40 Pain Relevance 0

General Comments

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