INT104931

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 17.44
Pain Relevance 2.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TNFSF10) extracellular space (TNFSF10) extracellular region (TNFSF10)
cell-cell signaling (TNFSF10)
Anatomy Link Frequency
T cell 3
monocyte 1
TNFSF10 (Homo sapiens)
Pain Link Frequency Relevance Heat
Arthritis 185 99.84 Very High Very High Very High
cytokine 66 96.76 Very High Very High Very High
rheumatoid arthritis 49 88.64 High High
cINOD 23 82.96 Quite High
Inflammation 191 81.12 Quite High
antagonist 2 75.72 Quite High
cva 3 46.00 Quite Low
Pain 2 28.64 Quite Low
Inflammatory mediators 6 27.76 Quite Low
COX2 5 25.00 Low Low
Disease Link Frequency Relevance Heat
Apoptosis 727 100.00 Very High Very High Very High
Death 132 100.00 Very High Very High Very High
Rheumatoid Arthritis 208 99.84 Very High Very High Very High
Disease 61 96.76 Very High Very High Very High
Systemic Lupus Erythematosus 12 96.40 Very High Very High Very High
Bacterial Infection 7 95.80 Very High Very High Very High
Myeloid Leukemia 26 95.48 Very High Very High Very High
Cholangiocarcinoma 2 93.64 High High
Cancer 321 93.56 High High
Necrosis 23 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This seems to be consistent with the report that TRAIL induces apoptosis by binding to TRAIL R1 and R2.
TRAIL Binding (binding) of associated with apoptosis
1) Confidence 0.36 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 0.77 Pain Relevance 0.14
In all myeloma cell lines analyzed, oligomerized TRAIL trimers induced caspase activation and complete cell death, whereas non-oligomerized TRAIL trimers showed no or only a modest effect.
TRAIL Spec (analyzed) Binding (oligomerized) of associated with death
2) Confidence 0.36 Published 2009 Journal FEBS J. Section Abstract Doc Link 19895579 Disease Relevance 1.04 Pain Relevance 0
TRAIL induces apoptosis by binding and cross-linking the death-domain containing receptors, TRAIL-R1 (DR4) and TRAIL-R2 (DR5) [3].
TRAIL Binding (binding) of associated with apoptosis and death
3) Confidence 0.35 Published 2006 Journal Arthritis Res Ther Section Body Doc Link PMC1526576 Disease Relevance 1.09 Pain Relevance 0.16
CD8+ T cell associated TRAIL and its receptor expression profile in RA
TRAIL Binding (associated) of in T cell associated with arthritis
4) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.62 Pain Relevance 0.27
CD8+ T cell associated TRAIL and its receptor expression profile in RA
TRAIL Binding (profile) of in T cell associated with arthritis
5) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 0.62 Pain Relevance 0.27
Membrane bound TRAIL and its receptor expression profile on peripheral CD4+ T lymphocytes in RA patients versus control individuals
TRAIL Binding (bound) of in T lymphocytes associated with arthritis
6) Confidence 0.30 Published 2010 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2936350 Disease Relevance 1.21 Pain Relevance 0.39
The effects induced by TRAIL are mediated by interactions with cell surface TRAIL receptors.
TRAIL Binding (interactions) of
7) Confidence 0.19 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.67 Pain Relevance 0.08
Binding of TRAIL to the death inducing receptors DR4/DR5 results in the recruitment of the Fas ┬ľassociated death domain (FADD) to the receptors, which initiates binding of procaspase-8 and procaspase-9, and the formation of the death inducing signaling complex (DISC) [9].
TRAIL Binding (Binding) of associated with death
8) Confidence 0.18 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.54 Pain Relevance 0.03
Collectively, our results suggest that unlike sulindac sulfide, SC-'236 in combination with Apo2L/TRAIL can overcome Bax deficiency to induce apoptosis.
Apo2L/TRAIL Binding (combination) of associated with apoptosis
9) Confidence 0.18 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 0.69 Pain Relevance 0.31
Collectively, our results suggest that unlike sulindac sulfide, SC-'236 in combination with Apo2L/TRAIL can overcome Bax deficiency to induce apoptosis.
Apo2L/TRAIL Binding (combination) of associated with apoptosis
10) Confidence 0.18 Published 2002 Journal Oncogene Section Abstract Doc Link 12203115 Disease Relevance 0.69 Pain Relevance 0.31
Very important death inducing ligands are the Fas ligand, TNF?
ligand Binding (ligands) of associated with death
11) Confidence 0.17 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.69 Pain Relevance 0
When they bind their specific death receptor, apoptotic signals are transmitted in the cell and a caspase cascade is activated within seconds of ligand binding, inducing apoptosis in a very rapid way.
ligand Binding (binding) of associated with apoptosis and death
12) Confidence 0.16 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2903979 Disease Relevance 1.68 Pain Relevance 0
TRAIL initiates apoptosis by binding to two death receptors, DR4 and DR5, while binding to the decoy receptors which lack the death domain, such as DCR1, DCR2 and osteoprotegerin, inhibits its pro-apoptotic activity [9].
TRAIL Binding (binding) of associated with apoptosis and death
13) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.69 Pain Relevance 0.07
We did not observe significant apoptosis rates in Huh7 treated with recombinant TRAIL and Mcl-1 siRNA.
TRAIL Binding (recombinant) of associated with apoptosis
14) Confidence 0.15 Published 2006 Journal BMC Cancer Section Body Doc Link PMC1601962 Disease Relevance 1.25 Pain Relevance 0
, TRAIL, CXCL10, and OSM) that we found prominently expressed in HMB-PP-stimulated monocyte-??
TRAIL Binding (found) of in monocyte
15) Confidence 0.05 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2637987 Disease Relevance 0.62 Pain Relevance 0.03
Apicidin overcomes resistance to TNF-related apoptosis inducing ligand (TRAIL) in K562 cells via inhibition of the PI3K/AKT pathway and nuclear translocation of NF-?
TRAIL Binding (ligand) of associated with apoptosis
16) Confidence 0.04 Published 2010 Journal Invest New Drugs Section Body Doc Link PMC3003795 Disease Relevance 0.59 Pain Relevance 0

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