INT104935

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Context Info
Confidence 0.74
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.54
Pain Relevance 0.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (AHR) cell morphogenesis (AHR) DNA binding (AHR)
response to stress (AHR) cytoplasm (AHR) signal transducer activity (AHR)
Anatomy Link Frequency
eosinophil 1
AHR (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 8 99.92 Very High Very High Very High
Chronic pancreatitis 1 96.56 Very High Very High Very High
c fibre 1 62.52 Quite High
depression 1 51.60 Quite High
Neuropathic pain 1 50.64 Quite High
Inflammation 33 36.88 Quite Low
antagonist 4 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
imagery 3 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Apoptosis 34 100.00 Very High Very High Very High
Pancreatic Cancer 9 99.80 Very High Very High Very High
Targeted Disruption 1 98.64 Very High Very High Very High
Asthma 22 97.76 Very High Very High Very High
Pancreatitis 1 96.56 Very High Very High Very High
Cancer 89 94.08 High High
Stress 36 64.32 Quite High
Bronchial Hyperreactivity 1 55.20 Quite High
Injury 1 54.48 Quite High
Depression 1 51.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In pancreatic cancer tissues, AhR mRNA and protein expression were localized in the cytoplasm of pancreatic cancer cells.
Localization (localized) of AhR associated with pancreatic cancer
1) Confidence 0.74 Published 2002 Journal Oncogene Section Abstract Doc Link 12203118 Disease Relevance 0.85 Pain Relevance 0.29
The AhR, upon binding of a ligand, forms a heterodimeric complex with ARNT (aryl hydrocarbon receptor nuclear translocator) which induces transactivation of the CYPs and other target genes via binding to xenobiotic response elements (XREs) in their promoter regions [63].
Localization (translocator) of aryl hydrocarbon receptor
2) Confidence 0.51 Published 2007 Journal BMC Pharmacol Section Body Doc Link PMC2194763 Disease Relevance 0 Pain Relevance 0
Though OVA-induced increases in AHR to nonspecific stimuli were not mediated by mMBP-1, this model may not require eosinophil degranulation for observed increases in AHR, the temporal and spatial release of MBP may not elicit an AHR response, or other eosinophil-derived granule protein may be responsible for AHR.
Localization (increases) of AHR in eosinophil
3) Confidence 0.40 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2843899 Disease Relevance 0.49 Pain Relevance 0.06
An antagonistic effect of estrogen on effluent-stimulated CYP1A activities [presumably due to the presence of aryl hydrocarbon receptor (AhR) agonists such as PAHs, PCBs, and dioxins] is in agreement with previous evidence for inhibitory effects of estrogens on both basal and AhR-induced CYP1A activities in fish tissues (e.g., Mdegela et al. 2006; Navas and Segner 2000).
Localization (presence) of AhR associated with agonist
4) Confidence 0.22 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.06 Pain Relevance 0.05
An antagonistic effect of estrogen on effluent-stimulated CYP1A activities [presumably due to the presence of aryl hydrocarbon receptor (AhR) agonists such as PAHs, PCBs, and dioxins] is in agreement with previous evidence for inhibitory effects of estrogens on both basal and AhR-induced CYP1A activities in fish tissues (e.g., Mdegela et al. 2006; Navas and Segner 2000).
Localization (presence) of aryl hydrocarbon receptor associated with agonist
5) Confidence 0.22 Published 2007 Journal Environ Health Perspect Section Body Doc Link PMC2137123 Disease Relevance 0.06 Pain Relevance 0.05
-catenin signaling pathway, aryl hydrocarbon receptor signaling (cell cycle and apoptosis or nuclear receptor signaling), LPS/IL-1 mediated inhibition of RXR function (nuclear receptor signaling) as well as various metabolic pathways (i.e.
Localization (receptor) of aryl hydrocarbon receptor associated with apoptosis
6) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2958950 Disease Relevance 1.07 Pain Relevance 0.08

General Comments

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