INT104940

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2004
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.90
Pain Relevance 0.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Prkcb) histone binding (Prkcb) plasma membrane (Prkcb)
nucleus (Prkcb) intracellular (Prkcb) cytoplasm (Prkcb)
Anatomy Link Frequency
AGS 1
Prkcb (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 1 85.84 High High
COX-2 inhibitor 4 84.36 Quite High
Kinase C 2 79.96 Quite High
nociceptor 1 77.00 Quite High
qutenza 3 76.72 Quite High
cINOD 2 63.44 Quite High
Root ganglion neuron 1 54.56 Quite High
Disease Link Frequency Relevance Heat
Stomach Cancer 5 95.92 Very High Very High Very High
Alagille Syndrome 2 95.52 Very High Very High Very High
Apoptosis 6 95.20 Very High Very High Very High
Gastrointestinal Neoplasms 1 65.24 Quite High
INFLAMMATION 1 62.88 Quite High
Ganglion Cysts 1 54.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SC-236 down-regulated the protein expression and kinase activity of PKC-beta(1), increased the expression of PKCdelta and PKCeta, but did not alter the expression of other PKC isoforms in AGS cells.
Gene_expression (expression) of PKC-beta in AGS associated with alagille syndrome
1) Confidence 0.03 Published 2002 Journal Oncogene Section Abstract Doc Link 12203123 Disease Relevance 0.85 Pain Relevance 0.29
The expression of PKCmu and PKCbeta1, but not of other PKC isoforms, was also enhanced by butyrate treatment, suggesting the possibility that these two isoforms might contribute to the enhanced activity of rVR1.
Gene_expression (expression) of PKCbeta1
2) Confidence 0.01 Published 2004 Journal J. Biol. Chem. Section Abstract Doc Link 15471852 Disease Relevance 0.05 Pain Relevance 0.30

General Comments

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