INT104954

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 4
Speculated 1
Reported most in Body
Documents 29
Total Number 30
Disease Relevance 17.71
Pain Relevance 13.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Mapk14) cell morphogenesis (Mapk14) response to stress (Mapk14)
cytoplasm (Mapk14) cytosol (Mapk14) nucleus (Mapk14)
Anatomy Link Frequency
microglia 10
spinal 6
cerebrospinal fluid 2
spinal cord 2
PSCs 2
Mapk14 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Spinal cord 151 100.00 Very High Very High Very High
Arthritis 24 100.00 Very High Very High Very High
Dorsal horn neuron 8 99.72 Very High Very High Very High
cytokine 75 99.60 Very High Very High Very High
Etanercept 10 99.60 Very High Very High Very High
Neuropathic pain 232 99.56 Very High Very High Very High
Sciatic nerve 54 99.54 Very High Very High Very High
Thermal hyperalgesia 10 99.44 Very High Very High Very High
lidocaine 17 99.32 Very High Very High Very High
Eae 46 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Hypoxia 102 100.00 Very High Very High Very High
Arthritis 24 100.00 Very High Very High Very High
Neuropathic Pain 398 99.56 Very High Very High Very High
Hyperalgesia 50 99.44 Very High Very High Very High
Apoptosis 65 99.26 Very High Very High Very High
Nervous System Injury 445 99.24 Very High Very High Very High
Injury 134 98.94 Very High Very High Very High
Infection 71 98.50 Very High Very High Very High
Pain 127 98.28 Very High Very High Very High
Cold Sores 2 98.24 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Intrathecal pretreatment of FR167653 attenuated incision-induced mechanical allodynia from 1 h to day 2 and significantly reduced activation of p38 in the dorsal horn 1 day after plantar incision.
Negative_regulation (reduced) of Positive_regulation (activation) of p38 in dorsal horn
1) Confidence 0.58 Published 2009 Journal Anesthesiology Section Body Doc Link 19104183 Disease Relevance 0.12 Pain Relevance 0
Indeed, intrathecal lidocaine treatment remarkably suppressed the activation of p38 mitogen-activated protein kinase (MAPK) in hyperactive microglia.
Negative_regulation (suppressed) of Positive_regulation (activation) of p38 in microglia associated with lidocaine
2) Confidence 0.46 Published 2010 Journal Anesth. Analg. Section Abstract Doc Link 20686009 Disease Relevance 0.29 Pain Relevance 0.81
Nerve conduction blockade in the sciatic nerve prevents but does not reverse the activation of p38 mitogen-activated protein kinase in spinal microglia in the rat spared nerve injury model.
Neg (not) Negative_regulation (reverse) of Positive_regulation (activation) of p38 in spinal associated with neuralgia, nervous system injury and sciatic nerve
3) Confidence 0.43 Published 2007 Journal Anesthesiology Section Title Doc Link 17667577 Disease Relevance 0.36 Pain Relevance 0.32
This blockade prevented but did not reverse p38 activation in spinal microglia.
Neg (not) Negative_regulation (reverse) of Positive_regulation (activation) of p38 in spinal
4) Confidence 0.43 Published 2007 Journal Anesthesiology Section Body Doc Link 17667577 Disease Relevance 0.05 Pain Relevance 0
Taken together, these findings show that minocycline given IT produces a potent and consistent antinociception in models of tissue injury and inflammation-evoked pain, and they provide strong support for the idea that this effect is mediated by direct inhibition of spinal microglia and subsequent activation of p38 in these cells.
Negative_regulation (inhibition) of Positive_regulation (activation) of p38 in microglia associated with pain, antinociception, inflammation, injury and intrathecal
5) Confidence 0.42 Published 2005 Journal Eur. J. Neurosci. Section Abstract Doc Link 16307586 Disease Relevance 0.71 Pain Relevance 0.85
Treatment of PSCs with SB203580 abolished the ethanol- and acetaldehyde-induced increase in p38 MAPK activity and also prevented the induction of alpha-SMA expression in PSCs.
Negative_regulation (abolished) of Positive_regulation (increase) of p38 in PSCs
6) Confidence 0.40 Published 2003 Journal Pancreas Section Body Doc Link 12883264 Disease Relevance 0 Pain Relevance 0
Pretreatment with tonabersat inhibited gap junction communication between neurons and satellite glia and blocked the increase in connexin 26 and active p38 levels in response to injection of both tumor necrosis factor-alpha (V2) and capsaicin (V1).
Negative_regulation (blocked) of Positive_regulation (increase) of p38 in neurons
7) Confidence 0.40 Published 2009 Journal Headache Section Body Doc Link 19125874 Disease Relevance 0 Pain Relevance 0
Lidocaine, by inhibiting the increase of intracellular calcium, also inhibited p38 MAPK activation and attenuated the production of proinflammatory cytokines (including TNF-alpha, IL-1beta, and IL-6), which were triggered by extracellular ATP in cultured rat microglia.


Negative_regulation (inhibited) of Positive_regulation (activation) of p38 in microglia
8) Confidence 0.34 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20686009 Disease Relevance 0 Pain Relevance 0
RESULTS: We found that lidocaine (in a dose-dependent manner) significantly attenuated p38 MAPK activation triggered by 1 mM ATP, by inhibiting the transcription of 3 cytokine messenger RNAs and causing a decrease in their respective protein concentrations (TNF-alpha, IL-1beta, and IL-6, P < 0.05, vs. the ATP group).
Negative_regulation (attenuated) of Positive_regulation (activation) of p38
9) Confidence 0.33 Published 2010 Journal Anesth. Analg. Section Body Doc Link 20686009 Disease Relevance 0 Pain Relevance 0
Bupivacaine induced a complete sensory and motor blockade and also significantly inhibited p38 activation and microglial proliferation in the spinal cord.
Negative_regulation (inhibited) of Positive_regulation (activation) of p38 in spinal cord associated with spinal cord
10) Confidence 0.29 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2759920 Disease Relevance 0.84 Pain Relevance 0.68
Third, SNI-induced microglial proliferation and p38 activation in the spinal cord was reduced by a complete sciatic nerve blockade with bupivacaine microspheres but not by a selective blockade of nociceptive fibers with RTX.
Neg (not) Negative_regulation (reduced) of Positive_regulation (activation) of p38 in sciatic nerve associated with nociception, nervous system injury, sciatic nerve and spinal cord
11) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.48 Pain Relevance 0.63
However during the period of the transmission block, the apoptosis of dorsal horn neurons [46] and the activation of p38 in microglia [25] are reduced.
Negative_regulation (reduced) of Positive_regulation (activation) of p38 in microglia associated with apoptosis and dorsal horn neuron
12) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.08 Pain Relevance 0.83
Recent studies have also shown that (1) nerve injury activates p38 mitogen-activated protein kinase (MAPK) in spinal microglia, (2) spinal infusion of p38 inhibitor attenuates neuropathic pain symptoms such as mechanical allodynia [16,23,24], and (3) blocking peripheral activity from the site of injury with bupivacaine microspheres prevents but does not reverse p38 activation in spinal microglia after spared nerve injury [25].
Neg (not) Negative_regulation (reverse) of Neg (not) Positive_regulation (activation) of p38 in nerve associated with nervous system injury, allodynia, injury and neuropathic pain
13) Confidence 0.29 Published 2009 Journal Mol Pain Section Body Doc Link PMC2759920 Disease Relevance 1.02 Pain Relevance 0.73
Western blot analysis showed that LPS treatment elicited the activation of ERK 1/2 and p38 MAP kinases.
Negative_regulation (elicited) of Positive_regulation (activation) of p38
14) Confidence 0.28 Published 2002 Journal Glia Section Abstract Doc Link 12203390 Disease Relevance 0.39 Pain Relevance 0.48
DPML significantly inhibited tumor necrosis factor alpha, interleukin-1beta, and cytokine-induced neutrophil chemoattractant-1 levels, suppressed neutrophil infiltration and myeloperoxidase activity, and inhibited NFkappaB and p38 mitogen-activated protein kinase activation in the lung.
Negative_regulation (inhibited) of Positive_regulation (activation) of p38 in neutrophil associated with necrosis, cancer and cytokine
15) Confidence 0.25 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18669445 Disease Relevance 0.71 Pain Relevance 0.57
These data suggest that SC-236 inhibits migration and cytokine production through suppression of p38 MAPK activation.
Negative_regulation (suppression) of Positive_regulation (activation) of p38 associated with cytokine
16) Confidence 0.24 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17320132 Disease Relevance 0.69 Pain Relevance 0.37
We also showed that SC-236 suppresses the SCF-induced p38 MAPK activation in RPMCs.
Negative_regulation (suppresses) of Positive_regulation (activation) of p38
17) Confidence 0.24 Published 2007 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 17320132 Disease Relevance 0.75 Pain Relevance 0.39
Lee et al. [42] reported constitutive expression of activated p38?
Negative_regulation (reported) of Positive_regulation (activated) of p38
18) Confidence 0.24 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2838742 Disease Relevance 0.90 Pain Relevance 0.33
IL-1beta-induced NO levels and thermal hyperalgesia in rats, likely via either inhibiting the IL-1beta-mediated p38 MAPK activation and subsequent iNOS induction, or direct attenuation of the central iNOS activity, which therefore reduces the central sensitization of inflammatory pain.
Negative_regulation (inhibiting) of Spec (likely) Positive_regulation (activation) of p38 associated with central sensitization, ipn and thermal hyperalgesia
19) Confidence 0.22 Published 2007 Journal Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists Section Abstract Doc Link 17694686 Disease Relevance 0.69 Pain Relevance 0.94
In DRG, p38 activation is blocked by systemic TNF-?
Negative_regulation (blocked) of Positive_regulation (activation) of p38
20) Confidence 0.14 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2096756 Disease Relevance 0.49 Pain Relevance 1.11

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