INT104977

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Context Info
Confidence 0.69
First Reported 2002
Last Reported 2002
Negated 0
Speculated 1
Reported most in Title
Documents 1
Total Number 5
Disease Relevance 0.91
Pain Relevance 3.71

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (MC1R) plasma membrane (MC1R) nucleus (MITF)
protein complex assembly (MITF) DNA binding (MITF) protein complex (MITF)
Anatomy Link Frequency
melanocytes 2
MITF (Homo sapiens)
MC1R (Homo sapiens)
Pain Link Frequency Relevance Heat
melanocortin 1 receptor 45 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Microphthalmia 10 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We investigated whether MITF regulates human MC1R gene expression through the same transcriptional mechanism as tyrosinase and TRP-1 genes in melanocytes.
MITF Spec (whether) Regulation (regulates) of Gene_expression (expression) of MC1R gene in melanocytes associated with melanocortin 1 receptor
1) Confidence 0.69 Published 2002 Journal Life Sci. Section Abstract Doc Link 12204775 Disease Relevance 0.17 Pain Relevance 0.72
Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R).
microphthalmia-associated transcription factor Regulation (Involvement) of Gene_expression (expression) of melanocortin-1 receptor associated with melanocortin 1 receptor and microphthalmia
2) Confidence 0.60 Published 2002 Journal Life Sci. Section Title Doc Link 12204775 Disease Relevance 0.19 Pain Relevance 0.75
Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R).
MITF Regulation (Involvement) of Gene_expression (expression) of melanocortin-1 receptor associated with melanocortin 1 receptor and microphthalmia
3) Confidence 0.60 Published 2002 Journal Life Sci. Section Title Doc Link 12204775 Disease Relevance 0.19 Pain Relevance 0.75
Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R).
MITF Regulation (Involvement) of Gene_expression (expression) of MC1R associated with melanocortin 1 receptor and microphthalmia
4) Confidence 0.51 Published 2002 Journal Life Sci. Section Title Doc Link 12204775 Disease Relevance 0.19 Pain Relevance 0.75
Involvement of microphthalmia-associated transcription factor (MITF) in expression of human melanocortin-1 receptor (MC1R).
microphthalmia-associated transcription factor Regulation (Involvement) of Gene_expression (expression) of MC1R associated with melanocortin 1 receptor and microphthalmia
5) Confidence 0.51 Published 2002 Journal Life Sci. Section Title Doc Link 12204775 Disease Relevance 0.19 Pain Relevance 0.75

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