INT104979

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Context Info
Confidence 0.62
First Reported 2002
Last Reported 2010
Negated 1
Speculated 4
Reported most in Body
Documents 51
Total Number 70
Disease Relevance 54.83
Pain Relevance 6.91

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (MITF) protein complex assembly (MITF) DNA binding (MITF)
protein complex (MITF)
Anatomy Link Frequency
T cells 7
endometrium 3
Visceral 2
lung 2
synovial fluid 1
MITF (Homo sapiens)
Pain Link Frequency Relevance Heat
endometriosis 435 99.84 Very High Very High Very High
melanocortin 1 receptor 9 99.84 Very High Very High Very High
cytokine 221 99.80 Very High Very High Very High
rheumatoid arthritis 1008 99.62 Very High Very High Very High
Inflammation 269 99.56 Very High Very High Very High
psoriasis 36 98.96 Very High Very High Very High
Chronic pancreatitis 40 93.96 High High
Pain 20 89.60 High High
pain pelvic 30 82.64 Quite High
Central nervous system 20 78.92 Quite High
Disease Link Frequency Relevance Heat
Microphthalmia 7 100.00 Very High Very High Very High
Colon Cancer 311 99.92 Very High Very High Very High
Cancer 4133 99.84 Very High Very High Very High
Endometriosis 495 99.84 Very High Very High Very High
Prostate Cancer 400 99.84 Very High Very High Very High
Reprotox - General 3 280 99.84 Very High Very High Very High
Leukemia 205 99.84 Very High Very High Very High
Lung Cancer 180 99.84 Very High Very High Very High
Choristoma 45 99.68 Very High Very High Very High
Rheumatoid Arthritis 1008 99.62 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Visceral SMCs also preferentially expressed microphthalmia-associated transcription factor (MITF).
Gene_expression (expressed) of microphthalmia-associated transcription factor in Visceral associated with microphthalmia
1) Confidence 0.62 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.69 Pain Relevance 0
Visceral SMCs also preferentially expressed microphthalmia-associated transcription factor (MITF).
Gene_expression (expressed) of MITF in Visceral associated with microphthalmia
2) Confidence 0.62 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.69 Pain Relevance 0
For this purpose, the effect of co-expression of cDNA encoding MITF on MC1R promoter activity in NIH/3T3 cells was studied.
Gene_expression (expression) of MITF associated with melanocortin 1 receptor
3) Confidence 0.60 Published 2002 Journal Life Sci. Section Abstract Doc Link 12204775 Disease Relevance 0.16 Pain Relevance 0.74
High levels of MITF may play a role in modulating the activity of the TGF-?
Gene_expression (levels) of MITF
4) Confidence 0.54 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.39 Pain Relevance 0.03
In addition to its expression in melanocytes and mast cells [41], MITF has been shown to be present in uterus and other tissues [42].
Gene_expression (present) of MITF in melanocytes
5) Confidence 0.54 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.54 Pain Relevance 0.03
In addition to its expression in melanocytes and mast cells [41], MITF has been shown to be present in uterus and other tissues [42].
Gene_expression (present) of MITF in mast cells
6) Confidence 0.18 Published 2007 Journal PLoS Genetics Section Body Doc Link PMC1994710 Disease Relevance 0.54 Pain Relevance 0.03
In CLL, the five most highly expressed miRNAs are miR-331, miR-29a, miR-195, miR-34a, and miR-29c.
Gene_expression (expressed) of miRNAs associated with chronic lymphoid leukemia
7) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.46 Pain Relevance 0
Additionally, cancer-miRNA network efficiently detect hub miRNAs dysregulated in many cancer types and identify cancer specific miRNAs.
Gene_expression (detect) of miRNAs associated with cancer
8) Confidence 0.01 Published 2010 Journal Silenc Section Abstract Doc Link PMC2835996 Disease Relevance 1.11 Pain Relevance 0
In [34], it has been shown that miR-181a family miRNAs are expressed at relatively low levels in AML.
Gene_expression (expressed) of miRNAs associated with myeloid leukemia
9) Confidence 0.01 Published 2010 Journal Silenc Section Body Doc Link PMC2835996 Disease Relevance 1.39 Pain Relevance 0
Four of the ten miRNAs were overexpressed in colorectal cancer samples (Figure 1).
Gene_expression (overexpressed) of miRNAs associated with colon cancer
10) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.41 Pain Relevance 0
Recent studies from our laboratory as well as those of other groups have shown that the expression of miRNAs is important in colorectal and other types of cancer (Benard and Douc-Rasy, 2005; Bottoni et al. 2005; Calin et al. 2002; Calin et al. 2005; Cimmino et al. 2005; Cummins et al. 2006; Xi et al. 2006). miRNA regulates gene expression at the post-transcriptional level by perfect or imperfect base pairing with many target mRNA transcripts (Chen and Meister, 2005; Mattick and Makunin, 2005).
Gene_expression (expression) of miRNAs associated with cancer
11) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.43 Pain Relevance 0
Among the ten miRNAs, hsa-miR-15b (p = 0.0278), hsa-miR-181b (p = 0.0002), hsa-miR-191 (p = 0.0264) and hsa-miR-200c (p = 0.0017) were significantly over-expressed in tumors compared to normal colorectal samples.
Gene_expression (expressed) of miRNAs associated with cancer
12) Confidence 0.01 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.60 Pain Relevance 0
The expression levels of 10 miRNAs were quantified via qRT-PCR analysis.
Gene_expression (expression) of miRNAs
13) Confidence 0.01 Published 2006 Journal Biomark Insights Section Abstract Doc Link PMC2134920 Disease Relevance 0.57 Pain Relevance 0
In this study, the expression levels of 10 different miRNAs known to be deregulated based on our previous studies were quantified using miRNA specific qRT-PCR analysis.
Gene_expression (expression) of miRNAs
14) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.40 Pain Relevance 0
In the current study, the expression levels of ten miRNAs (hsa-miR-30a-5p, hsa-miR-181b, hsa-let-7g, hsa-miR-26a, hsa-let-7b, has-miR-15b, has-miR-27a, has-miR-200c, has-miR-191, and has-miR-30c) were investigated to evaluate their clinical relevance in colorectal cancer. 24 normal and paired colorectal cancer specimens were selected as a model for this investigation.
Spec (investigated) Gene_expression (expression) of miRNAs associated with colon cancer
15) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.90 Pain Relevance 0
Among these, four miRNAs were found to be overexpressed in colorectal cancer samples.
Gene_expression (overexpressed) of miRNAs associated with colon cancer
16) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.48 Pain Relevance 0
We also compared the expression status of miRNAs within the tumors with or without p53 mutations.
Gene_expression (expression) of miRNAs associated with cancer
17) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.64 Pain Relevance 0
To further evaluate the clinical relevance of these overexpressed miRNAs in colorectal cancer in terms of prognosis, Kaplan-Meier survival analysis was performed using patient overall survival.
Gene_expression (overexpressed) of miRNAs associated with colon cancer
18) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.62 Pain Relevance 0
Overexpression of these miRNAs may be due to the loss of p53 tumor suppressor function in tumors.


Gene_expression (Overexpression) of miRNAs associated with cancer
19) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.91 Pain Relevance 0.05
Overexpression of miRNAs in Colorectal Cancer
Gene_expression (Overexpression) of miRNAs associated with colon cancer
20) Confidence 0.01 Published 2006 Journal Biomark Insights Section Body Doc Link PMC2134920 Disease Relevance 0.38 Pain Relevance 0

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