INT10498

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Context Info
Confidence 0.19
First Reported 1985
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 8
Disease Relevance 1.76
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Tcn2) extracellular region (Tcn2)
Anatomy Link Frequency
leg 2
spinal 1
blood 1
plasma 1
skin 1
Tcn2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
anesthesia 154 98.60 Very High Very High Very High
Pain 16 97.52 Very High Very High Very High
aspirin 5 95.08 Very High Very High Very High
ischemia 5 73.72 Quite High
analgesia 12 57.36 Quite High
Restless leg syndrome 2 50.00 Quite Low
qutenza 2 10.00 Low Low
Ultiva 14 5.00 Very Low Very Low Very Low
cva 12 5.00 Very Low Very Low Very Low
Versed 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 13 97.68 Very High Very High Very High
Pain 16 97.52 Very High Very High Very High
Amputation 1 87.20 High High
Peripheral Arterial Disease 5 77.56 Quite High
Cv Unclassified Under Development 13 73.72 Quite High
Hypoventilation 6 56.84 Quite High
Sleep Disorders 14 49.04 Quite Low
Injury 16 16.48 Low Low
Burns 4 16.20 Low Low
Fever 2 7.88 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
RESULTS: Under basal conditions (skin temperature, 37 degrees C to 39 degrees C), both basal blood flow and tcPO2 increased with increasing age.
Positive_regulation (increased) of tcPO2 in skin
1) Confidence 0.19 Published 2005 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Body Doc Link 15814863 Disease Relevance 0 Pain Relevance 0
Capsaicin increased blood flow and tcPO2 in all age groups, with the young showing a greater increase compared with the older participants.
Positive_regulation (increased) of tcPO2 in blood
2) Confidence 0.19 Published 2005 Journal J. Gerontol. A Biol. Sci. Med. Sci. Section Body Doc Link 15814863 Disease Relevance 0 Pain Relevance 0
In limbs with a tcPO2 below 15 mm Hg of patients in the supine position breathing room air, leg dependency generally provoked larger tcPO2 increases than oxygen inhalation.
Positive_regulation (increases) of tcPO2 in leg
3) Confidence 0.18 Published 1992 Journal J. Vasc. Surg. Section Abstract Doc Link 1495145 Disease Relevance 0.53 Pain Relevance 0.15
TcPO2 increased in the anesthetized area by spinal anesthesia.
Positive_regulation (increased) of TcPO2 in spinal associated with anesthesia
4) Confidence 0.01 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946031 Disease Relevance 0.20 Pain Relevance 0.57
After oxygen administration, the increase in tcPO2 was larger in the non-anesthetized area, although the absolute values were not different between anesthetized and non-anesthetized areas [119].
Positive_regulation (increase) of tcPO2
5) Confidence 0.01 Published 2010 Journal Korean Journal of Anesthesiology Section Body Doc Link PMC2946031 Disease Relevance 0.14 Pain Relevance 0.57
Both treatments resulted in a statistically significant increase in TcPO2 and decrease in plasma fibrinogen but under calcium-heparin treatment these modifications were doubled in comparison with ASA (p < 0.01 and p < 0.05, respectively for TcPO2 and fibrinogen).
Positive_regulation (increase) of TcPO2 in plasma associated with aspirin
6) Confidence 0.00 Published 1994 Journal Int J Clin Pharmacol Ther Section Abstract Doc Link 7881702 Disease Relevance 0.20 Pain Relevance 0.23
CONCLUSION: TcPO2 is not required in patients with Leriche stage II intermittent claudication but might be useful either in severely affected patients (Leriche stage III or IV) or in selected patients.


Neg (not) Positive_regulation (required) of TcPO2
7) Confidence 0.00 Published 1995 Journal Angiology Section Body Doc Link 7702195 Disease Relevance 0.05 Pain Relevance 0
The TcPO2 readings increased significantly (P less than 0.05) in the three groups (N, IC, RP) at all leg levels (HT, ATC, DF) when the patient breathed 40% O2 with and without HEB.
Positive_regulation (increased) of TcPO2 in leg associated with pain and increased venous pressure under development
8) Confidence 0.00 Published 1985 Journal J Cardiovasc Surg (Torino) Section Abstract Doc Link 4066735 Disease Relevance 0.63 Pain Relevance 0.35

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