INT1050

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Context Info
Confidence 0.58
First Reported 1976
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 21
Total Number 25
Disease Relevance 5.33
Pain Relevance 4.20

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
arm 4
dorsal 1
medial 1
brain 1
posterior 1
hpc (Mus musculus)
Pain Link Frequency Relevance Heat
palliative 454 100.00 Very High Very High Very High
Hippocampus 237 100.00 Very High Very High Very High
medulla 2 99.74 Very High Very High Very High
cINOD 65 99.48 Very High Very High Very High
amygdala 24 94.36 High High
monoamine 1 80.72 Quite High
Nucleus accumbens 22 78.24 Quite High
local anesthetic 1 68.32 Quite High
Pain 4 66.56 Quite High
anesthesia 13 59.84 Quite High
Disease Link Frequency Relevance Heat
Anxiety Disorder 110 99.96 Very High Very High Very High
Neurodegenerative Disease 330 99.80 Very High Very High Very High
Attention Deficit Hyperactivity Disorder 77 99.78 Very High Very High Very High
Targeted Disruption 145 99.28 Very High Very High Very High
Myelodysplastic Syndromes 60 99.12 Very High Very High Very High
Disease 273 96.88 Very High Very High Very High
Ataxia 4 84.56 Quite High
Stress 10 69.84 Quite High
Pain 4 66.56 Quite High
Dyspnea 4 65.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, the evolution of HPC across the case study provinces has been markedly slow, but steady and continuous.
Gene_expression (evolution) of HPC
1) Confidence 0.58 Published 2010 Journal BMC Health Serv Res Section Body Doc Link 20515491 Disease Relevance 0 Pain Relevance 0
After choosing the case study provinces, the grey literature was searched to create a preliminary timeline for each that described the evolution of HPC beginning in 1970.
Gene_expression (evolution) of HPC
2) Confidence 0.58 Published 2010 Journal BMC Health Serv Res Section Body Doc Link 20515491 Disease Relevance 0 Pain Relevance 0
Electrical stimulation and microinfusion techniques were utilized in acute experiments on urethane-anesthetized rats in order to evaluate the hypothesis that the posterior hypothalamic and supramammillary nuclei comprise a critical part of the ascending brainstem pathway for producing synchronous hippocampal formation (HPC) field activity (theta).
Gene_expression (producing) of HPC in posterior associated with medulla
3) Confidence 0.52 Published 1994 Journal Hippocampus Section Abstract Doc Link 7874237 Disease Relevance 0 Pain Relevance 0.16
Entorhinal cortex (and HPC) production of theta could be abolished by pharmacological treatments disrupting cholinergic transmission, and by reversible procaine inactivation of the medial septal region.
Gene_expression (production) of HPC in medial
4) Confidence 0.52 Published 1994 Journal Hippocampus Section Abstract Doc Link 8061751 Disease Relevance 0 Pain Relevance 0
The Resident Assessment Instrument for Palliative Care (RAI-PC) [11] is also starting pilot tests in Canada and that tool will also have impacts on what data is collected by HPC programs.
Gene_expression (programs) of HPC associated with palliative
5) Confidence 0.45 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2396153 Disease Relevance 0.08 Pain Relevance 0.98
A common MDS would enable research to be done about the provision of HPC in Canada such as comparing length of stay, access to and use of hospice palliative services and management of symptoms.
Gene_expression (provision) of HPC associated with myelodysplastic syndromes and palliative
6) Confidence 0.45 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2396153 Disease Relevance 0.55 Pain Relevance 0.92
That was done partially because we had access to the database schemas of the seven HPC centres and also because we believe HPC data collection needs to move towards electronic collection.
Gene_expression (collection) of HPC associated with palliative
7) Confidence 0.45 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2396153 Disease Relevance 0 Pain Relevance 0.65
The data element for whether the patient is aware of the HPC prognosis is the least captured element with Toronto being the only centre collecting it.
Gene_expression (prognosis) of HPC associated with palliative
8) Confidence 0.45 Published 2008 Journal BMC Palliat Care Section Body Doc Link PMC2396153 Disease Relevance 0.18 Pain Relevance 0.50
AICD impairs HPC proliferation in mice lacking APP
Gene_expression (proliferation) of HPC
9) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912762 Disease Relevance 0.33 Pain Relevance 0
, is also able to impair HPC proliferation.


Gene_expression (proliferation) of HPC
10) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912762 Disease Relevance 0.75 Pain Relevance 0.10
To examine whether reduced HPC proliferation is also accompanied by reduced neurogenesis, we immunostained the brain sections with anti-doublecortin (DCX) antibody.
Spec (whether) Gene_expression (proliferation) of HPC in brain associated with neurodegenerative disease
11) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912762 Disease Relevance 0.72 Pain Relevance 0.03
We measured HPC proliferation in the SGZ by injecting male AICD transgenic mice (line FeC?
Gene_expression (proliferation) of HPC associated with targeted disruption
12) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912762 Disease Relevance 0.99 Pain Relevance 0
Treatment with NSAIDs prevents the deficits in HPC proliferation and neurogenesis
Gene_expression (proliferation) of HPC associated with cinod and neurodegenerative disease
13) Confidence 0.29 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2912762 Disease Relevance 0.76 Pain Relevance 0.10
In contrast, the dHPC and cHPC groups did not show this dramatic reduction in HR choices following the introduction of the barrier.
Gene_expression (groups) of dHPC
14) Confidence 0.15 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0
Indeed, both the dHPC and cHPC lesioned rats were perfectly capable of choosing the HR when there was an equivalent delay to reinforcement in both arms (postoperative stage 2), and when there was no delay in either arm (Expt 2, no barrier condition).
Gene_expression (lesioned) of dHPC in arm
15) Confidence 0.15 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0.04
Furthermore, it is interesting to note that both the cHPC and dHPC groups were in fact initially more willing to climb the barrier than controls and vHPC lesioned rats.
Gene_expression (groups) of dHPC
16) Confidence 0.15 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0
Indeed, ventral but not dorsal HPC lesions produce anxiolytic effects on unconditioned tests of anxiety (Deacon, Bannerman, & Rawlins, 2002; Kjelstrup et al., 2002; McHugh, Deacon, Rawlins, & Bannerman, 2004).
Gene_expression (produce) of HPC in dorsal associated with anxiety disorder
17) Confidence 0.15 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.20 Pain Relevance 0.12
For example, studies using the peak interval procedure suggest that HPC lesions lead to an inconsistency in time estimation (Buhusi, Mocanu, & Meck, 2005; Meck, Church, & Olton, 1984).
Gene_expression (lesions) of HPC
18) Confidence 0.15 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0.05
The dHPC group also chose the HR arm more often than the shams (p < .05) and there was a trend toward the dHPC group choosing the HR arm more than the vHPC group (p = .08).
Gene_expression (choosing) of dHPC in arm
19) Confidence 0.15 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0 Pain Relevance 0
After the introduction of the delay, controls continued to choose the CRF arm, but HPC lesioned rats switched their preference to the immediate PRF arm.
Gene_expression (lesioned) of HPC in arm
20) Confidence 0.15 Published 2008 Journal Behav Neurosci Section Body Doc Link PMC2671844 Disease Relevance 0.15 Pain Relevance 0

General Comments

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