INT105003

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Context Info
Confidence 0.04
First Reported 2002
Last Reported 2002
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0.49
Pain Relevance 0.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (SHMT2) methyltransferase activity (SHMT2) cell death (PDYN)
extracellular region (PDYN) plasma membrane (PDYN)
PDYN (Homo sapiens)
SHMT2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 1 91.32 High High
Opioid 2 72.20 Quite High
Dynorphin 1 71.92 Quite High
Neuropeptide 1 68.08 Quite High
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Schizophrenia 5 100.00 Very High Very High Very High
Mental Disorders 1 76.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We conclude that PDYN gene polymorphism alone does not alter the risk for schizophrenia but, by an epistatic interaction with the Gly allele of DRD3 gene, may contribute to the susceptibility to this disorder.
PDYN gene Binding (interaction) of Gly allele associated with schizophrenia
1) Confidence 0.04 Published 2002 Journal Neuropsychobiology Section Abstract Doc Link 12207142 Disease Relevance 0.49 Pain Relevance 0.26

General Comments

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