INT105008

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Context Info
Confidence 0.36
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 3.15
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (DRD3) signal transducer activity (DRD3)
DRD3 (Homo sapiens)
Pain Link Frequency Relevance Heat
Dopamine 101 100.00 Very High Very High Very High
addiction 78 99.24 Very High Very High Very High
withdrawal 24 98.60 Very High Very High Very High
depression 29 97.96 Very High Very High Very High
Nicotine 185 93.36 High High
drug abuse 9 86.48 High High
Opioid 9 85.68 High High
noradrenaline 1 82.92 Quite High
Dynorphin 1 82.12 Quite High
Neuropeptide 3 78.28 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 15 99.44 Very High Very High Very High
Substance Withdrawal Syndrome 6 98.78 Very High Very High Very High
Nicotine Addiction 344 98.48 Very High Very High Very High
Depression 34 97.96 Very High Very High Very High
Schizophrenia 5 96.84 Very High Very High Very High
Manic Depressive Disorder 125 91.76 High High
Targeted Disruption 1 86.96 High High
Mental Disorders 5 86.20 High High
Psychosis 4 75.92 Quite High
Alcohol Addiction 21 71.36 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, we observed a significant interactive effect with the receptor 3 of dopamine gene (DRD3); in particular, the frequency of subjects carrying PDYN allele 3 being also homozygotes for DRD3 Gly allele (of Ser9Gly polymorphism) was significantly greater in patients than controls.
DRD3 Binding (effect) of associated with dopamine
1) Confidence 0.36 Published 2002 Journal Neuropsychobiology Section Abstract Doc Link 12207142 Disease Relevance 0.51 Pain Relevance 0.29
Here, we will review the information collected implicating the receptors of the D1 family (DRD1 and DRD5) and of the D2 family (DRD2, DRD3 and DRD4) in drug addiction.
DRD3 Binding (receptors) of associated with drug dependence and addiction
2) Confidence 0.33 Published 2009 Journal Behav Pharmacol Section Abstract Doc Link 19179847 Disease Relevance 0.58 Pain Relevance 0.53
Recent investigations have found that DRD2 is associated with withdrawal symptoms, such as difficulty in concentrating and sleeping, and that DRD3 is associated with age of initiation, heaviness of smoking, and depression during withdrawal [99].
DRD3 Binding (associated) of associated with nicotine addiction, depression and withdrawal
3) Confidence 0.21 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2669467 Disease Relevance 0.77 Pain Relevance 0.51
Recent investigations have found that DRD2 is associated with withdrawal symptoms, such as difficulty in concentrating and sleeping, and that DRD3 is associated with age of initiation, heaviness of smoking, and depression during withdrawal [99].
DRD3 Binding (associated) of associated with nicotine addiction, depression and withdrawal
4) Confidence 0.21 Published 2004 Journal Tob Induc Dis Section Body Doc Link PMC2671538 Disease Relevance 0.77 Pain Relevance 0.51
Aiming to evaluate common genetic variation for association with clinical improvement in BDI depression following treatment with OFC, Perlis et al. [200] analyzed a cohort of 88 patients treated with OFC, showing significant association for dopamine D3 receptor (DRD3) and HRH1 genes and response to OFC.
dopamine D3 receptor Spec (analyzed) Binding (association) of associated with dopamine and depression
5) Confidence 0.06 Published 2010 Journal Human Genomics and Proteomics : HGP Section Body Doc Link PMC2958627 Disease Relevance 0.53 Pain Relevance 0.21

General Comments

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