INT10504

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Context Info
Confidence 0.65
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 18
Total Number 18
Disease Relevance 8.19
Pain Relevance 5.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Pla2g1b) extracellular space (Pla2g1b) extracellular region (Pla2g1b)
response to stress (Pla2g1b)
Anatomy Link Frequency
polymorphonuclear leukocytes 1
Pla2g1b (Mus musculus)
Pain Link Frequency Relevance Heat
cytokine 10 100.00 Very High Very High Very High
Inflammation 164 99.14 Very High Very High Very High
Pain 42 98.94 Very High Very High Very High
Chronic pancreatitis 10 98.80 Very High Very High Very High
Analgesic 5 97.96 Very High Very High Very High
adenocard 5 96.84 Very High Very High Very High
allodynia 6 95.28 Very High Very High Very High
corticosteroid 14 95.08 Very High Very High Very High
Spinal cord 9 88.88 High High
cINOD 24 88.36 High High
Disease Link Frequency Relevance Heat
Cancer 136 99.92 Very High Very High Very High
Necrosis 1 99.64 Very High Very High Very High
Pancreatitis 18 99.52 Very High Very High Very High
INFLAMMATION 193 99.14 Very High Very High Very High
Adhesions 5 99.12 Very High Very High Very High
Pain 33 98.94 Very High Very High Very High
Injury 17 98.80 Very High Very High Very High
Intervertebral Disk Displacement 2 98.12 Very High Very High Very High
Neuropathic Pain 6 95.28 Very High Very High Very High
Hypoxia 2 93.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present study was carried out, using inhibitors to secretory phospholipase A2 (sPLA2, 12-epi-scalaradial), cytosolic phospholipase A2 (cPLA2, AACOCF3), or calcium-independent phospholipase A2 (iPLA2, bromoenol lactone), to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice.
Localization (secretory) of phospholipase A2 associated with allodynia
1) Confidence 0.65 Published 2004 Journal Pain Section Abstract Doc Link 15494195 Disease Relevance 0.17 Pain Relevance 0.24
The present study was carried out, using inhibitors to secretory phospholipase A2 (sPLA2, 12-epi-scalaradial), cytosolic phospholipase A2 (cPLA2, AACOCF3), or calcium-independent phospholipase A2 (iPLA2, bromoenol lactone), to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice.
Localization (secretory) of phospholipase A2 associated with allodynia
2) Confidence 0.65 Published 2004 Journal Pain Section Abstract Doc Link 15494195 Disease Relevance 0.17 Pain Relevance 0.23
The present study was carried out, using inhibitors to secretory phospholipase A2 (sPLA2, 12-epi-scalaradial), cytosolic phospholipase A2 (cPLA2, AACOCF3), or calcium-independent phospholipase A2 (iPLA2, bromoenol lactone), to compare possible contributions of central nervous PLA2 isoforms to the development of allodynia after facial carrageenan injection in mice.
Localization (secretory) of phospholipase A2 associated with allodynia
3) Confidence 0.57 Published 2004 Journal Pain Section Abstract Doc Link 15494195 Disease Relevance 0.17 Pain Relevance 0.23
Manoalide inhibits phospholipase A2 from extracellular sources (snake venoms, bee, etc.), the release of arachidonic acid from rabbit polymorphonuclear leukocytes as well as calcium mobilization.
Localization (release) of phospholipase A2 in polymorphonuclear leukocytes
4) Confidence 0.49 Published 1989 Journal Medicina (B Aires) Section Abstract Doc Link 2640487 Disease Relevance 0.18 Pain Relevance 0.14
In vitro, the pseudopterosins were inactive as inhibitors of phospholipase A2, cyclooxygenase, cytokine release, or as regulators of adhesion molecule expression.
Localization (release) of phospholipase A2 associated with adhesions and cytokine
5) Confidence 0.40 Published 1998 Journal Life Sci. Section Abstract Doc Link 9651113 Disease Relevance 0.25 Pain Relevance 0.25
Duodenal secretion of phospholipase A2, amylase, and bicarbonate in chronic pancreatitis.
Localization (secretion) of phospholipase A2 associated with chronic pancreatitis
6) Confidence 0.20 Published 1998 Journal J. Gastroenterol. Section Title Doc Link 9605959 Disease Relevance 0.71 Pain Relevance 0.27
In 1995, a candidate was identified, the secretory phospholipase A2 gene (sPLA2), which is believed to account for about 50% of the variation seen in Min mice [57].
Localization (secretory) of phospholipase A2
7) Confidence 0.17 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 0.71 Pain Relevance 0.05
Secretory phospholipase A2 is one of several enzymes involved in generating arachidonic acid and lysophosphatidic acid.
Localization (Secretory) of phospholipase A2
8) Confidence 0.17 Published 2003 Journal Hered Cancer Clin Pract Section Body Doc Link PMC2840009 Disease Relevance 0.55 Pain Relevance 0.13
The synthesis of these typical mediators of inflammation results from activation by the calcium of phospholipase A2 which releases the arachidonic acid of phospholipids and this increase in intracellular calcium results itself from a fall in efficacy of calcium pumps due to the fall in ATP caused by hypoxia.
Localization (releases) of phospholipase A2 associated with inflammation and hypoxia
9) Confidence 0.14 Published 1992 Journal Phlebologie Section Abstract Doc Link 1496030 Disease Relevance 0.51 Pain Relevance 0.20
Those PAR activators induced a calcium independent phospholipase A2 with the consequent release of arachidonic acid and synthesis of prostaglandin E2 [30].
Localization (release) of phospholipase A2
10) Confidence 0.11 Published 2007 Journal BMC Physiol Section Body Doc Link PMC1853108 Disease Relevance 1.24 Pain Relevance 0.20
The formed lipocortin inhibits the activity of phospholipase A2, which releases arachidonic acid, the precursor of prostanoids and leukotrienes, from phospholipids.
Localization (releases) of phospholipase A2
11) Confidence 0.10 Published 1989 Journal Acta Derm Venereol Suppl (Stockh) Section Abstract Doc Link 2533778 Disease Relevance 0.23 Pain Relevance 0.43
Pain due to disc protrusion is thought to arise from the release of arachidonic acid metabolites namely prostaglandin E2, thromboxane, phospholipase A2, tumour necrosis factor, and interleukin from herniated disc cells.
Localization (release) of phospholipase A2 associated with pain, necrosis, intervertebral disk displacement and cancer
12) Confidence 0.08 Published 2010 Journal The Korean Journal of Pain Section Body Doc Link PMC3000622 Disease Relevance 1.33 Pain Relevance 1.20
This is the first finding that the frog secretes a phospholipase A2 similar to that of snake venoms, which posess inhibitory activity against the adenosine A1, adenosine A2 and muscarinic receptors.
Localization (secretes) of phospholipase A2 associated with adenocard
13) Confidence 0.07 Published 2000 Journal Eur. J. Biochem. Section Abstract Doc Link 10691971 Disease Relevance 0 Pain Relevance 0.38
Prostaglandin synthesis is regulated at multiple steps, including: (1) phospholipase A2, which releases arachidonic acid from membrane phospholipids; (2) PGH synthase (PGHS), which converts arachidonic acid to the endoperoxides PGG2 and PGH2; and (3) PG synthases convert the endoperoxides to PGI2, PGE2, and others.
Localization (releases) of phospholipase A2
14) Confidence 0.06 Published 1995 Journal Semin. Nephrol. Section Abstract Doc Link 7631046 Disease Relevance 0.09 Pain Relevance 0.18
Urinary phospholipase A2 excretion in chronic pancreatic diseases.
Localization (excretion) of phospholipase A2 associated with pancreatitis
15) Confidence 0.06 Published 1992 Journal Int. J. Pancreatol. Section Title Doc Link 1517657 Disease Relevance 0.87 Pain Relevance 0.31
However, injury also triggers the immediate calcium-mediated activation of phospholipase A2 (PLA2), the release of arachidonic acid, and the enzymatic formation of potentially deleterious prostaglandins (PGE2 alpha, PGE2), thromboxane A2 (TXA2), and leukotrienes (LTs).
Localization (release) of phospholipase A2 associated with injury
16) Confidence 0.06 Published 1995 Journal J. Neurotrauma Section Abstract Doc Link 7473799 Disease Relevance 0.43 Pain Relevance 0.22
bodies, and are released by cytosolic phospholipase A2 (cPLA2) [13]. ?
Localization (released) of phospholipase A2
17) Confidence 0.05 Published 2008 Journal PPAR Research Section Body Doc Link PMC2606065 Disease Relevance 0.13 Pain Relevance 0.07
In mammalian cells, eicosanoid biosynthesis is usually initiated by the activation of phospholipase A2 and the release of arachidonic acid (AA) from membrane phospholipids.
Localization (release) of phospholipase A2
18) Confidence 0.04 Published 2007 Journal Curr Top Med Chem Section Abstract Doc Link 17305573 Disease Relevance 0.46 Pain Relevance 0.33

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