INT105044

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.99
Pain Relevance 0.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Flt1) endosome (Flt1) Golgi apparatus (Flt1)
nucleolus (Flt1) plasma membrane (Flt1) nucleus (Flt1)
Anatomy Link Frequency
retinas 1
Flt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
palliative 1 91.04 High High
imagery 45 63.28 Quite High
corticosteroid 8 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
ketamine 4 5.00 Very Low Very Low Very Low
metalloproteinase 4 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
positron emission tomography 3 5.00 Very Low Very Low Very Low
Inflammation 2 5.00 Very Low Very Low Very Low
isoflurane 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 8 100.00 Very High Very High Very High
Glioma 53 98.68 Very High Very High Very High
Diabetes Mellitus 55 98.28 Very High Very High Very High
Cancer 196 96.24 Very High Very High Very High
Malignant Neoplastic Disease 6 93.76 High High
Reprotox - General 1 4 92.32 High High
Atopic Dermatitis 1 86.68 High High
Chills 1 85.88 High High
Fever 1 85.56 High High
Toxicity 2 84.20 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Transcription of Vegf-a and Flk-1 was significantly increased by 2.5- and 1.8-fold (PVegf-a = 0.001 and PFlk-1 = 0.031), respectively, but Flt-1 was downregulated 4.3-fold (PFlt-1 = 0.005) in sham-treated diabetic retinas compared with sham-treated nondiabetic retinas (Fig. 1A).
Negative_regulation (downregulated) of Flt-1 in retinas associated with diabetes mellitus
1) Confidence 0.39 Published 2008 Journal Diabetes Section Body Doc Link PMC2836241 Disease Relevance 0.26 Pain Relevance 0
The mRNA and protein expression of VEGF and its receptors Flt1 and Flk1 were compared in control CSF and 5 mM GLA treated animals.
Negative_regulation (compared) of Flt1
2) Confidence 0.29 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 0.49 Pain Relevance 0
Very recently, VEGFR tyrosine kinase inhibitor (Vetanalib, PTK787) was used in glioma patient in conjunction with chemotherapy and radiotherapy.
Negative_regulation (inhibitor) of VEGFR associated with glioma
3) Confidence 0.14 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2806917 Disease Relevance 0.60 Pain Relevance 0.06
During therapy TNF-alpha concentrations raised markedly in the ascites fluid whereas VEGF and sFLT-1 ascites levels declined.
Negative_regulation (declined) of sFLT-1 associated with pressure and volume under development
4) Confidence 0.00 Published 2002 Journal Int. J. Cancer Section Abstract Doc Link 12209996 Disease Relevance 1.64 Pain Relevance 0.09

General Comments

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