INT10506

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Context Info
Confidence 0.76
First Reported 1989
Last Reported 2010
Negated 1
Speculated 0
Reported most in Abstract
Documents 86
Total Number 103
Disease Relevance 37.57
Pain Relevance 28.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
platelet 30
epithelial cells 5
eosinophils 4
IEC-6 3
embryos 3
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 549 100.00 Very High Very High Very High
substance P 492 100.00 Very High Very High Very High
Inflammatory mediators 357 100.00 Very High Very High Very High
calcitonin gene related peptide 288 100.00 Very High Very High Very High
addiction 23 99.92 Very High Very High Very High
qutenza 140 99.88 Very High Very High Very High
Inflammation 1591 99.84 Very High Very High Very High
COX2 1 99.78 Very High Very High Very High
bradykinin 57 99.76 Very High Very High Very High
agonist 115 99.68 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 1924 100.00 Very High Very High Very High
Adhesions 217 100.00 Very High Very High Very High
Otitis Media With Effusion 276 99.92 Very High Very High Very High
Injury 328 99.84 Very High Very High Very High
Esophageal Cancer 2 99.60 Very High Very High Very High
Ocular Hypertension 33 99.30 Very High Very High Very High
Wheal 27 99.30 Very High Very High Very High
Edema 87 98.92 Very High Very High Very High
Interstitial Cystitis 18 98.86 Very High Very High Very High
Mucositis 52 98.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Tolfenamic and meclofenamic acids were the most potent fenamates to inhibit PAF synthesis (IC50s 37 and 51 microM) as well as migration towards LTB4 (IC50s 61 and 92 microM).
Gene_expression (synthesis) of PAF
1) Confidence 0.76 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.14 Pain Relevance 0.76
Indomethacin inhibited LTB4 and PAF synthesis whereas ketoprofen reduced degranulation.
Gene_expression (synthesis) of PAF
2) Confidence 0.76 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.80
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Gene_expression (production) of PAF in platelet associated with paracetamol, cinod and diclofenac
3) Confidence 0.76 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.16 Pain Relevance 0.56
The aim of the present study was to compare the effects of chemically different NSAIDs (diclofenac, indomethacin, ketoprofen, paracetamol, piroxicam and four fenamates: flufenamic, meclofenamic, mefenamic and tolfenamic acids) on human polymorphonuclear leukocyte (PMN) functions, i.e. calcium ionophore A23187-triggered degranulation, leukotriene B4 (LTB4) release, platelet-activating factor (PAF) production and migration towards LTB4.
Gene_expression (production) of platelet-activating factor in platelet associated with paracetamol, cinod and diclofenac
4) Confidence 0.76 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.16 Pain Relevance 0.56
Out of the other NSAIDs, diclofenac (which is chemically related to fenamates) suppressed degranulation as well as LTB4 and PAF production.
Gene_expression (production) of PAF associated with cinod and diclofenac
5) Confidence 0.76 Published 1994 Journal Naunyn Schmiedebergs Arch. Pharmacol. Section Abstract Doc Link 7708126 Disease Relevance 0.13 Pain Relevance 0.80
For neutrophils, it has been shown that PAF synthesis is inhibited by cAMP.
Gene_expression (synthesis) of PAF in neutrophils
6) Confidence 0.75 Published 1996 Journal Eur Respir J Suppl Section Abstract Doc Link 8871060 Disease Relevance 0.08 Pain Relevance 0.19
However, at comparable concentrations, only nimesulide was able to inhibit the synthesis of PAF and LTC4 in activated eosinophils.
Gene_expression (synthesis) of PAF in eosinophils
7) Confidence 0.75 Published 1996 Journal Eur Respir J Suppl Section Abstract Doc Link 8871060 Disease Relevance 0.07 Pain Relevance 0.18
The effect of salmeterol and nimesulide on chemotaxis and synthesis of PAF and LTC4 by human eosinophils.
Gene_expression (synthesis) of PAF in eosinophils
8) Confidence 0.75 Published 1996 Journal Eur Respir J Suppl Section Title Doc Link 8871060 Disease Relevance 0.09 Pain Relevance 0.21
In the present study, we have, therefore, measured the effect of salmeterol and nimesulide on two important human eosinophil functions: chemotaxis; and synthesis of PAF and leukotriene C4 (LTC4).
Gene_expression (synthesis) of PAF in eosinophil
9) Confidence 0.75 Published 1996 Journal Eur Respir J Suppl Section Abstract Doc Link 8871060 Disease Relevance 0.07 Pain Relevance 0.19
Furthermore, PAF can induce eosinophil accumulation and enhance the expression of PAF receptors, which leads to increased vascular permeability, edema, and itching [31-33].
Gene_expression (expression) of PAF in eosinophil associated with pruritus and edema
10) Confidence 0.75 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2693427 Disease Relevance 0.71 Pain Relevance 0.46
The secreted form of PLA2-II, responsible for the extracellular production of PAF, is expressed by many cell types including intestinal paneth cells and its release is triggered by hypoxia, endotoxemia, and trauma among other stimuli.
Gene_expression (production) of PAF in paneth cells associated with endotoxemia, hypoxia and injury
11) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.16 Pain Relevance 0.07
Furthermore, in cells over-expressing PAFR, treatment with PAF resulted in a dose-dependent activation of a TLR4 promoter reporter construct, and in an in vivo model, luminal perfusion of an ileal loop with PAF resulted in enhanced intestinal TLR4 gene expression.
Gene_expression (expressing) of PAFR
12) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.94 Pain Relevance 0.17
Our current study sought to provide a link between PAF and TLR4 expression in explaining how their interaction could shed light on the pathogenesis of NEC.
Gene_expression (expression) of PAF associated with neonatal necrotizing enterocolitis
13) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.64 Pain Relevance 0.06
We, therefore, performed immunohistochemistry using anti-STAT3 on IEC-6 cells and COS-7 cells (which express very low levels of endogenous PAFR) transfected with human PAFR.
Gene_expression (express) of PAFR in IEC-6
14) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Platelet activating factor (PAF) is a potent endogenous, extracellular and intracellular phospholipid mediator, produced by a two-step enzymatic process where phosphatidyl choline is the de novo precursor and phospholipase A2 (PLA2-II) is the rate-limiting enzyme.
Gene_expression (produced) of Platelet activating factor in Platelet
15) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 1.04 Pain Relevance 0.08
Nimesulide also decreases histamine release from tissue mast cells and inhibits the production of platelet-activating factor by human basophils.
Gene_expression (production) of platelet-activating factor in platelet
16) Confidence 0.71 Published 1993 Journal Drugs Section Abstract Doc Link 7506193 Disease Relevance 0.16 Pain Relevance 0.32
Pretreatment of HBMEC with MAFP significantly increased PAF production in both unstimulated and tryptase-stimulated cells.
Gene_expression (production) of PAF
17) Confidence 0.68 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15937147 Disease Relevance 0.59 Pain Relevance 0.43
Because the design of selective PLA(2) inhibitors may provide a useful therapeutic strategy to reduce the inflammatory process in IC, we tested several frequently used PLA(2) inhibitors on PAF production in tryptase-stimulated HBMEC.
Gene_expression (production) of PAF associated with inflammation and interstitial cystitis
18) Confidence 0.68 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15937147 Disease Relevance 0.67 Pain Relevance 0.49
Andrographolide, an active principle of the Chinese drug Andrographis paniculata, used for prevention and treatment of common cold in Scandinavia and known as an antiinflammatory, antiviral, antithrombotic, hypotensive and antiatherosclerotic drug, was investigated for its suggested influence on the biosynthesis of eicosanoids and the platelet-activating factor (PAF).
Gene_expression (biosynthesis) of PAF in platelet associated with common cold, inflammation and hypotension
19) Confidence 0.68 Published 1999 Journal Phytomedicine Section Abstract Doc Link 10228608 Disease Relevance 0.36 Pain Relevance 0.07
Andrographolide, an active principle of the Chinese drug Andrographis paniculata, used for prevention and treatment of common cold in Scandinavia and known as an antiinflammatory, antiviral, antithrombotic, hypotensive and antiatherosclerotic drug, was investigated for its suggested influence on the biosynthesis of eicosanoids and the platelet-activating factor (PAF).
Gene_expression (biosynthesis) of platelet-activating factor in platelet associated with common cold, inflammation and hypotension
20) Confidence 0.68 Published 1999 Journal Phytomedicine Section Abstract Doc Link 10228608 Disease Relevance 0.36 Pain Relevance 0.07

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