INT10507

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Context Info
Confidence 0.61
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 21
Disease Relevance 10.24
Pain Relevance 6.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleolus (PTAFR) plasma membrane (PTAFR) nucleus (PTAFR)
signal transducer activity (PTAFR)
Anatomy Link Frequency
platelet 16
immune cells 4
endothelial cell 4
muscle 4
IEC-6 2
PTAFR (Homo sapiens)
Pain Link Frequency Relevance Heat
substance P 189 100.00 Very High Very High Very High
calcitonin gene related peptide 112 100.00 Very High Very High Very High
Inflammatory mediators 109 99.56 Very High Very High Very High
Inflammation 353 99.20 Very High Very High Very High
Migraine 16 98.76 Very High Very High Very High
interstitial cystitis 18 93.48 High High
antagonist 126 82.88 Quite High
chemokine 63 82.72 Quite High
cytokine 80 79.44 Quite High
Pain 4 75.00 Quite High
Disease Link Frequency Relevance Heat
Adhesions 12 100.00 Very High Very High Very High
INFLAMMATION 436 99.20 Very High Very High Very High
Hypoxia 10 98.84 Very High Very High Very High
Headache 14 98.76 Very High Very High Very High
Injury 75 98.12 Very High Very High Very High
Neonatal Necrotizing Enterocolitis 136 98.08 Very High Very High Very High
Esophageal Disease 154 95.68 Very High Very High Very High
Gastroesophageal Reflux Disease 84 95.08 Very High Very High Very High
Interstitial Cystitis 18 93.48 High High
Influenza Virus Infection 23 92.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pretreatment of HBMEC with MAFP significantly increased PAF production in both unstimulated and tryptase-stimulated cells.
Positive_regulation (increased) of Gene_expression (production) of PAF
1) Confidence 0.61 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15937147 Disease Relevance 0.59 Pain Relevance 0.44
Production of PAF in esophageal epithelial cells, in response to TRPV1 activation has been confirmed in the human esophageal epithelial cell line HET-1A, where the sequential steps beginning with TRPV1 receptor activation and resulting in PAF production has been elucidated.56

6.

Positive_regulation (resulting) of Gene_expression (production) of PAF in epithelial cells
2) Confidence 0.51 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0 Pain Relevance 0.17
The increased production of PAF may account for persistent platelet activation during migraine crises, even in the presence of an increased production of nitric oxide (NO) end-products which, on the other hand, should instead intervene in counteracting and limiting platelet activation.
Positive_regulation (increased) of Gene_expression (production) of PAF in platelet associated with migraine
3) Confidence 0.47 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15265050 Disease Relevance 0.59 Pain Relevance 0.54
Platelet-activating factor induced TLR4 expression is inhibited by STAT3 and NF?
Positive_regulation (induced) of Gene_expression (expression) of Platelet-activating factor in Platelet
4) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Intraluminal perfusion of PAF in isolated ileal loop
Positive_regulation (perfusion) of Gene_expression (perfusion) of PAF
5) Confidence 0.47 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.09 Pain Relevance 0.05
We have previously shown that tryptase increases human bladder microvascular endothelial cell (HBMEC) calcium-independent phospholipase A(2) (iPLA(2)) activity, resulting in the production of multiple biologically active phospholipid metabolites, including platelet-activating factor (PAF), that can mediate inflammation.
Positive_regulation (resulting) of Gene_expression (production) of platelet-activating factor in endothelial cell associated with inflammation
6) Confidence 0.44 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15937147 Disease Relevance 0.72 Pain Relevance 0.54
We have previously shown that tryptase increases human bladder microvascular endothelial cell (HBMEC) calcium-independent phospholipase A(2) (iPLA(2)) activity, resulting in the production of multiple biologically active phospholipid metabolites, including platelet-activating factor (PAF), that can mediate inflammation.
Positive_regulation (resulting) of Gene_expression (production) of PAF in endothelial cell associated with inflammation
7) Confidence 0.44 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15937147 Disease Relevance 0.72 Pain Relevance 0.54
Our findings provide initial mechanistic explanations for PAF-induced TLR4 expression.
Positive_regulation (explanations) of Gene_expression (expression) of PAF-induced
8) Confidence 0.43 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0.28 Pain Relevance 0
We, therefore, performed immunohistochemistry using anti-STAT3 on IEC-6 cells and COS-7 cells (which express very low levels of endogenous PAFR) transfected with human PAFR.
Positive_regulation (transfected) of Gene_expression (transfected) of PAFR in IEC-6
9) Confidence 0.38 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2955554 Disease Relevance 0 Pain Relevance 0
Since cellular immune infiltrate is a prerequisite for severe inflammation and tissue damage, inhibition of IL-8, SP and PAF-induced PBL migration and activation may provide potential targets for therapy.


Positive_regulation (activation) of Gene_expression (migration) of PAF associated with inflammation and substance p
10) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.59 Pain Relevance 0.64
Since cellular immune infiltrate is a prerequisite for severe inflammation and tissue damage, inhibition of IL-8, SP and PAF-induced PBL migration and activation may provide potential targets for therapy.


Positive_regulation (induced) of Gene_expression (migration) of PAF associated with inflammation and substance p
11) Confidence 0.37 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.58 Pain Relevance 0.64
H2O2 may contribute to further production of PAF and cause upregulation of NOX in the mucosa and muscle.
Positive_regulation (contribute) of Gene_expression (production) of PAF in muscle
12) Confidence 0.34 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.50 Pain Relevance 0.34
The increased production of PAF may account for persistent platelet activation during migraine crises, even in the presence of an increased production of nitric oxide (NO) end-products which, on the other hand, should instead intervene in counteracting and limiting platelet activation.
Positive_regulation (increased) of Gene_expression (production) of PAF in platelet associated with migraine
13) Confidence 0.34 Published 2004 Journal Cephalalgia Section Abstract Doc Link 15265050 Disease Relevance 0.59 Pain Relevance 0.54
We propose that acid in the lumen of the esophagus activates TRPV1 receptors causing the production and release of PAF, SP and CGRP that, in turn, may attract and activate immune cells contributing to inflammation and injury of the esophageal mucosa.
Positive_regulation (activate) of Gene_expression (production) of PAF in immune cells associated with calcitonin gene related peptide, inflammation, injury and substance p
14) Confidence 0.32 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.85 Pain Relevance 0.44
We propose that acid in the lumen of the esophagus activates TRPV1 receptors causing the production and release of PAF, SP and CGRP that, in turn, may attract and activate immune cells contributing to inflammation and injury of the esophageal mucosa.
Positive_regulation (causing) of Gene_expression (production) of PAF in immune cells associated with calcitonin gene related peptide, inflammation, injury and substance p
15) Confidence 0.32 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.84 Pain Relevance 0.43
This indicates that PAF is a major mucosa-derived mediator depressing muscle contraction.41 PAF can also activate the esophageal circular muscle to secrete IL-6.41 The muscle-derived IL-6 then leads to enhanced production of H2O2, which in turn induces the secretion of IL-1.41,42 H2O2 and IL-1 can themselves induce PAF production (Fig. 13).
Positive_regulation (induce) of Gene_expression (production) of PAF in muscle
16) Confidence 0.32 Published 2010 Journal Journal of Neurogastroenterology and Motility Section Body Doc Link PMC2978390 Disease Relevance 0.39 Pain Relevance 0.22
Thrombin and tryptase stimulation resulted in activation of a Ca(2+)-independent PLA(2), leading to increased release of arachidonic acid and prostacyclin and increased production of platelet-activating factor.
Positive_regulation (leading) of Gene_expression (production) of platelet-activating factor in platelet
17) Confidence 0.29 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15561975 Disease Relevance 0.49 Pain Relevance 0.31
Thrombin and tryptase stimulation resulted in activation of a Ca(2+)-independent PLA(2), leading to increased release of arachidonic acid and prostacyclin and increased production of platelet-activating factor.
Positive_regulation (increased) of Gene_expression (production) of platelet-activating factor in platelet
18) Confidence 0.20 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15561975 Disease Relevance 0.48 Pain Relevance 0.30
Thrombin and tryptase stimulation resulted in activation of a Ca(2+)-independent PLA(2), leading to increased release of arachidonic acid and prostacyclin and increased production of platelet-activating factor.
Positive_regulation (increased) of Gene_expression (production) of platelet-activating factor in platelet
19) Confidence 0.20 Published 2005 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 15561975 Disease Relevance 0.49 Pain Relevance 0.31
When endothelial cells are subjected to hypoxia, there is stimulation of the cells which shows itself as increased synthesis of prostaglandins and of PAF (Platelet Activating Factor).
Positive_regulation (increased) of Gene_expression (synthesis) of PAF in Platelet associated with hypoxia
20) Confidence 0.08 Published 1992 Journal Phlebologie Section Abstract Doc Link 1496030 Disease Relevance 0.47 Pain Relevance 0.19

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