INT105086

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Context Info
Confidence 0.49
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 9
Total Number 9
Disease Relevance 5.82
Pain Relevance 1.45

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CYCS) transport (CYCS) mitochondrion (CYCS)
small molecule metabolic process (CYCS) nucleus (CYCS)
Anatomy Link Frequency
neuronal 1
brain 1
apoptotic cell 1
CYCS (Homo sapiens)
Pain Link Frequency Relevance Heat
cocaine 16 94.64 High High
Buprenorphine 2 93.96 High High
Analgesic 2 93.40 High High
Calcium channel 1 91.88 High High
cINOD 5 91.80 High High
antagonist 1 90.60 High High
anesthesia 2 89.48 High High
Morphine 1 68.48 Quite High
lidocaine 4 50.00 Quite Low
COX-2 inhibitor 1 50.00 Quite Low
Disease Link Frequency Relevance Heat
Apoptosis 173 100.00 Very High Very High Very High
Death 18 99.98 Very High Very High Very High
Brain Injury 7 99.72 Very High Very High Very High
Breast Cancer 2 98.00 Very High Very High Very High
Benign Prostatic Hypertrophy 2 96.88 Very High Very High Very High
Necrosis 5 95.68 Very High Very High Very High
Injury 8 93.96 High High
Colon Cancer 4 93.04 High High
Parkinson's Disease 1 93.00 High High
Stress 3 87.36 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cytochrome c release and caspase activation after traumatic brain injury.
Positive_regulation (activation) of Cytochrome c in brain associated with brain injury
1) Confidence 0.49 Published 2002 Journal Brain Res. Section Title Doc Link 12213303 Disease Relevance 1.19 Pain Relevance 0.09
TR3 induces apoptosis in a number of cell lineages exposed to proapoptotic stimuli by directly targeting the mitochondria, inducing cytochrome c release.
Positive_regulation (inducing) of cytochrome c associated with apoptosis
2) Confidence 0.49 Published 2003 Journal Cancer Res. Section Abstract Doc Link 14500374 Disease Relevance 0.73 Pain Relevance 0.07
This apoptosis-like cell death activated key molecules in the mitochondrial apoptotic pathway: cytochrome c, caspase-9, caspase-7, and caspase-6.
Positive_regulation (activated) of cytochrome c associated with apoptosis and death
3) Confidence 0.49 Published 2004 Journal Life Sci. Section Abstract Doc Link 15135650 Disease Relevance 1.08 Pain Relevance 0.26
Since cytochrome c and its generation of ROS are involved in indomethacin-induced cellular apoptosis, rebamipide may attenuate mitochondrial damage.
Positive_regulation (generation) of cytochrome c associated with apoptosis
4) Confidence 0.49 Published 2005 Journal Dig. Dis. Sci. Section Abstract Doc Link 16184425 Disease Relevance 0.79 Pain Relevance 0.24
We hypothesized that apoptotic cell death occurs in the cardiac cells through calcium accumulation, production of reactive oxygen species, and the cytochrome c-mediated PARP activation pathway.
Positive_regulation (occurs) of cytochrome c in apoptotic cell associated with apoptosis and death
5) Confidence 0.49 Published 2009 Journal Free Radic. Biol. Med. Section Abstract Doc Link 19497364 Disease Relevance 0.69 Pain Relevance 0.09
SC236-induced apoptosis was coupled with release of cytochrome c and activation of caspases.
Positive_regulation (activation) of cytochrome c
6) Confidence 0.45 Published 2006 Journal Digestion Section Body Doc Link 16641552 Disease Relevance 0.14 Pain Relevance 0
The authors evaluated cell viability, mitochondrial alterations, cytochrome c release, caspase activation, and early apoptosis.
Positive_regulation (activation) of cytochrome c
7) Confidence 0.45 Published 2007 Journal Anesthesiology Section Body Doc Link 17585225 Disease Relevance 0.09 Pain Relevance 0
Conversely, a major increase in cytochrome c release, caspase 3-dependent apoptosis, and decreased metabolic neuronal viability were observed upon sequential exposure to Her and Coc.
Positive_regulation (increase) of cytochrome c in neuronal associated with apoptosis and cocaine
8) Confidence 0.45 Published 2010 Journal Toxicology Section Abstract Doc Link 20600547 Disease Relevance 0.80 Pain Relevance 0.69
Finally, the pro-survival BCL2L2 or BCL-W and GLRX2 [78,79] genes, in addition to the induction of BCL2 and CYCS (encodes cytochrome c) that also occurs in WT cells, were induced in WTSTS cells.
Positive_regulation (induction) of CYCS
9) Confidence 0.25 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2996966 Disease Relevance 0.31 Pain Relevance 0

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