INT10510

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Context Info
Confidence 0.45
First Reported 1992
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 13
Total Number 13
Disease Relevance 10.37
Pain Relevance 2.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
blood 1
bile 1
CII 1
saliva 1
Igh-6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
lidocaine 9 99.32 Very High Very High Very High
cocaine 10 99.14 Very High Very High Very High
Inflammation 75 98.08 Very High Very High Very High
cytokine 53 97.04 Very High Very High Very High
Bile 1 94.16 High High
methotrexate 82 93.52 High High
Arthritis 200 86.88 High High
Multiple sclerosis 3 81.08 Quite High
rheumatoid arthritis 38 80.88 Quite High
abdominal pain 2 79.20 Quite High
Disease Link Frequency Relevance Heat
Agammaglobulinemia 12 100.00 Very High Very High Very High
Syndrome 10 99.96 Very High Very High Very High
Celiac Disease 20 99.74 Very High Very High Very High
Neuromyelitis Optica 9 99.54 Very High Very High Very High
Arthritis 209 99.26 Very High Very High Very High
Immunodeficiency 40 98.78 Very High Very High Very High
Pressure And Volume Under Development 67 98.20 Very High Very High Very High
INFLAMMATION 79 98.08 Very High Very High Very High
Peripheral Arterial Disease 102 97.88 Very High Very High Very High
Infection 43 95.20 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, rats treated with COC and LIDO in combination had significantly decreased serum immunoglobulin M (IgM) concentration.
Negative_regulation (decreased) of IgM associated with lidocaine and cocaine
1) Confidence 0.45 Published 1996 Journal Toxicol. Lett. Section Abstract Doc Link 9001588 Disease Relevance 0 Pain Relevance 1.19
P. amboinicus significantly inhibited the footpad swelling and arthritic symptoms in collagen-induced arthritic rats, while the serum anti-collagen IgM and CRP levels were consistently decreased.
Negative_regulation (decreased) of IgM associated with pressure and volume under development and arthritis
2) Confidence 0.33 Published 2010 Journal Evidence-based Complementary and Alternative Medicine : eCAM Section Abstract Doc Link PMC2816374 Disease Relevance 1.35 Pain Relevance 0.42
Anti-CII antibody levels in sera from rats treated with combination therapy were markly decreased, as were levels of IgG1, IgG2a, IgG2b and IgM.
Negative_regulation (decreased) of IgM in CII
3) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656239 Disease Relevance 0.54 Pain Relevance 0.25
In addition, T-614 (20 mg/kg per day) depressed production of anti-type II collagen antibodies and differentially affected levels of IgG2a subclasses in vivo, whereas IgM level was decreased without any change in the IgG1 level.
Negative_regulation (decreased) of IgM
4) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Abstract Doc Link PMC2656239 Disease Relevance 0.85 Pain Relevance 0.33
Likewise, decrease in IgM and increase in Hb, as well as wellbeing (Karnofsky performance scale), were observed.[83] T. cordifolia prevents antitubercular drugs[8485] and bile salts[86] induced hepatic damage, x and obstructive jaundice.[87] The extract has also exhibited in vitro inactivating property against hepatitis B and E surface antigens in 48 to 72 hours.[88]

ANTI-HYPERGLYCEMIC ACTIVITY

Negative_regulation (decrease) of IgM in bile associated with bile, hepatitis and obstructive jaundice
5) Confidence 0.10 Published 2010 Journal International Journal of Ayurveda Research Section Body Doc Link PMC2924974 Disease Relevance 0.64 Pain Relevance 0.08
The cohort included 50 men and 41 women, aged 20–82 years, with various PAD diagnoses: Common variable immunodeficiency (n = 66), X-linked Agammaglobulinemia (n = 8), Selective IgA deficiency (n = 16) and Hyper IgM syndrome (n = 1).
Negative_regulation (deficiency) of Hyper IgM associated with syndrome, agammaglobulinemia, peripheral arterial disease and immunodeficiency
6) Confidence 0.05 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1177979 Disease Relevance 1.14 Pain Relevance 0
Distribution of the specific PAD diagnoses was: Common Variable Immunodeficiency (n = 43), X-linked Agammaglobulinemi (n = 3), Selective IgA deficiency (n = 8) and Hyper IgM syndrome (n = 1).
Negative_regulation (deficiency) of Hyper IgM associated with syndrome, peripheral arterial disease and immunodeficiency
7) Confidence 0.05 Published 2005 Journal Health Qual Life Outcomes Section Body Doc Link PMC1177979 Disease Relevance 1.18 Pain Relevance 0
Total serum levels of immunoglobulin G and M were high before treatment, but immunoglobulin M levels decreased significantly in week 8 during treatment with danazol, whereas C4 levels increased and C3 levels decreased with danazol.
Negative_regulation (decreased) of immunoglobulin M
8) Confidence 0.04 Published 1992 Journal Am. J. Obstet. Gynecol. Section Body Doc Link 1497054 Disease Relevance 0.07 Pain Relevance 0
The active lesions of the rats exhibited pathological characteristics strikingly similar to those of NMO, marked by astrocytic loss and perivascular deposition of immunoglobulin and complements.
Negative_regulation (loss) of immunoglobulin associated with neuromyelitis optica
9) Confidence 0.03 Published 2009 Journal Biochem. Biophys. Res. Commun. Section Abstract Doc Link 19545538 Disease Relevance 1.09 Pain Relevance 0.19
The most common changes in immune cell function after strenuous exercise comprise decreased neutrophil activity, impaired antibody synthesis, decreased immunoglobulin levels in blood and saliva, decreased cytolytic activity of natural killer (NK) cells, lower circulating T lymphocyte number for 3–4?
Negative_regulation (decreased) of immunoglobulin in blood
10) Confidence 0.02 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442120 Disease Relevance 0.45 Pain Relevance 0.07
Immunoglobulin deficiency, especially deficiency of IgA, has been described in patients with celiac sprue (CS).
Negative_regulation (deficiency) of Immunoglobulin associated with celiac disease and agammaglobulinemia
11) Confidence 0.01 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9412941 Disease Relevance 1.02 Pain Relevance 0
The most common changes in immune cell function after strenuous exercise comprise decreased neutrophil activity, impaired antibody synthesis, decreased immunoglobulin levels in blood and saliva, decreased cytolytic activity of natural killer (NK) cells, lower circulating T lymphocyte number for 3–4?
Negative_regulation (decreased) of immunoglobulin in saliva
12) Confidence 0.01 Published 2004 Journal Evidence-based Complementary and Alternative Medicine Section Body Doc Link PMC442120 Disease Relevance 0.45 Pain Relevance 0.07
Our study was performed in an area of high prevalence of CS to determine the prevalence of immunodeficiency states in patients with CS, to examine their clinical characteristics, response to treatment, and HLA phenotypes compared with a group of age- and sex-matched persons with CS but without immunoglobulin deficiency.
Neg (without) Negative_regulation (deficiency) of immunoglobulin associated with celiac disease, agammaglobulinemia and immunodeficiency
13) Confidence 0.00 Published 1997 Journal J. Clin. Gastroenterol. Section Abstract Doc Link 9412941 Disease Relevance 1.58 Pain Relevance 0.08

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