INT105103

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Context Info
Confidence 0.39
First Reported 2002
Last Reported 2010
Negated 4
Speculated 2
Reported most in Abstract
Documents 11
Total Number 13
Disease Relevance 3.15
Pain Relevance 9.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Casp3) peptidase activity (Casp3) mitochondrion (Casp3)
nucleus (Casp3) intracellular (Casp3) cytoplasm (Casp3)
Casp3 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 81 100.00 Very High Very High Very High
agonist 32 100.00 Very High Very High Very High
cocaine 25 100.00 Very High Very High Very High
antagonist 21 100.00 Very High Very High Very High
narcan 2 96.40 Very High Very High Very High
Clonidine 12 95.76 Very High Very High Very High
Eae 4 95.60 Very High Very High Very High
analgesia 2 94.00 High High
Opioid 3 93.60 High High
Cannabinoid receptor 8 92.12 High High
Disease Link Frequency Relevance Heat
Apoptosis 61 96.48 Very High Very High Very High
Targeted Disruption 7 96.24 Very High Very High Very High
Death 24 93.64 High High
Reperfusion Injury 2 86.72 High High
Hypertrophic Cardiomyopathy 1 85.44 High High
Cleidocranial Dysplasia 1 84.28 Quite High
Myocardial Infarction 3 83.36 Quite High
Dilated Cardiomyopathy 2 82.36 Quite High
INFLAMMATION 11 79.48 Quite High
Alcoholic Cardiomyopathy 5 76.80 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Administration of the plant extract (25, 50 and 100 mg/kg, i.p.) 30 min before the test did not change the expression of morphine-induced CPP.
Neg (not) Regulation (change) of Gene_expression (expression) of CPP associated with morphine
1) Confidence 0.39 Published 2006 Journal J Ethnopharmacol Section Abstract Doc Link 16182480 Disease Relevance 0 Pain Relevance 0.66
In the second set of experiments, the drugs were used before testing on Day 5, to test their effects on the expression of morphine-induced CPP.
Regulation (effects) of Gene_expression (expression) of CPP associated with morphine
2) Confidence 0.30 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 1.41
In this study, the decreased expression of Bcl-2, up-regulated expression of caspase-3 and Bax, as well as increased TUNEL positive cells depicted the presence of a global myocardial apoptosis following acute ethanol exposure.
Regulation (regulated) of Gene_expression (expression) of caspase-3 associated with apoptosis
3) Confidence 0.24 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2807457 Disease Relevance 1.72 Pain Relevance 0.08
The effect of imipramine and alpha-adrenoceptor agonists and antagonists on the acquisition or expression of morphine-induced conditioned place preference (CPP) was studied in mice.
Regulation (effect) of Gene_expression (expression) of CPP associated with antagonist, agonist and morphine
4) Confidence 0.24 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 0.60
In the second set of experiments, when the drugs were used before testing on Day 6, in order to test their effects on the expression of morphine-induced CPP, imipramine (0.5-5 mg/kg) reversed morphine-induced CPP and this reversal was blocked by naloxone (2 mg/kg).
Regulation (effects) of Gene_expression (expression) of CPP associated with narcan and morphine
5) Confidence 0.24 Published 2002 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 12213541 Disease Relevance 0 Pain Relevance 1.36
The

expression of RGS1 and CC3 remained unaltered up to 12 hours (Figure 1) but was

Regulation (unaltered) of Gene_expression (expression) of CC3
6) Confidence 0.21 Published 2008 Journal Journal of Biomedicine and Biotechnology Section Body Doc Link PMC2276817 Disease Relevance 0 Pain Relevance 0
The gene expression of caspase 3 was not increased in ECM and was independent of rhEpo treatment, indicating that they are possibly not involved in the induction of apoptosis in ECM.
Neg (independent) Regulation (independent) of Gene_expression (expression) of caspase 3 associated with apoptosis
7) Confidence 0.17 Published 2008 Journal Malar J Section Body Doc Link PMC2257967 Disease Relevance 0.80 Pain Relevance 0.12
This study was designed to determine the effects of alpha-adrenoceptor agonists and antagonists on the acquisition or expression of morphine-induced conditioned place preference (CPP) in female mice.
Spec (determine) Regulation (effects) of Spec (determine) Gene_expression (expression) of CPP associated with antagonist, agonist and morphine
8) Confidence 0.13 Published 2004 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 15159143 Disease Relevance 0 Pain Relevance 0.81
The main purpose of this study was to investigate the effects of Cuminum cyminum fruit essential oil (FEO) on the acquisition and expression of morphine-induced conditioned place preference (CPP) in mice.
Spec (investigate) Regulation (effects) of Spec (investigate) Gene_expression (expression) of CPP associated with morphine
9) Confidence 0.12 Published 2008 Journal Neurosci. Lett. Section Abstract Doc Link 18950682 Disease Relevance 0 Pain Relevance 0.42
Although SR reduces the acquisition of CPP induced by cocaine, morphine or food in a dose-depend manner, it does not affect the expression of the cocaine-induced CPP [24].
Neg (not) Regulation (affect) of Gene_expression (expression) of CPP associated with morphine and cocaine
10) Confidence 0.05 Published 2010 Journal Behav Brain Funct Section Body Doc Link PMC2858089 Disease Relevance 0.29 Pain Relevance 0.84
Low-dosed MPEP did not genuinely block development of cocaine- and morphine-CPP, but rendered CPP expression state-dependent.
Regulation (dependent) of Gene_expression (expression) of CPP associated with morphine and cocaine
11) Confidence 0.03 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15555632 Disease Relevance 0.13 Pain Relevance 0.97
Cocaine-CPP expression was not affected by any MPEP-dose.
Neg (not) Regulation (affected) of Gene_expression (expression) of CPP associated with cocaine
12) Confidence 0.02 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15555632 Disease Relevance 0.11 Pain Relevance 0.98
In conclusion, mGluR5 are involved in modulation of spontaneous and cocaine-induced locomotion, in state-dependent learning and in expression of morphine-CPP.
Regulation (involved) of Gene_expression (expression) of CPP associated with morphine and cocaine
13) Confidence 0.02 Published 2004 Journal Neuropharmacology Section Abstract Doc Link 15555632 Disease Relevance 0.10 Pain Relevance 0.98

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