INT105114

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Context Info
Confidence 0.52
First Reported 2002
Last Reported 2011
Negated 0
Speculated 2
Reported most in Abstract
Documents 16
Total Number 21
Disease Relevance 21.88
Pain Relevance 4.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
plasma cells 2
B cells 2
pancreas 2
pancreatic duct 2
Arigg4 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 116 99.80 Very High Very High Very High
Chronic pancreatitis 55 99.28 Very High Very High Very High
corticosteroid 133 98.84 Very High Very High Very High
Inflammation 49 98.00 Very High Very High Very High
Bile 29 97.72 Very High Very High Very High
fibrosis 71 96.56 Very High Very High Very High
Pain 13 96.12 Very High Very High Very High
abdominal pain 43 88.24 High High
alcohol 3 83.88 Quite High
Inflammatory marker 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pancreatitis 766 99.84 Very High Very High Very High
Disease 170 99.36 Very High Very High Very High
Carcinoma 1 99.28 Very High Very High Very High
Pancreatic Cancer 12 98.60 Very High Very High Very High
Biliary Liver Cirrhosis 5 98.40 Very High Very High Very High
Increased Venous Pressure Under Development 2 98.16 Very High Very High Very High
INFLAMMATION 56 98.00 Very High Very High Very High
Primary Sclerosing Cholangitis 5 97.32 Very High Very High Very High
Retroperitoneal Fibrosis 26 97.20 Very High Very High Very High
Hemorrhage 1 97.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
CONTEXT: Autoimmune pancreatitis is characterised by a lymphoplasmacytic infiltrate consisting in part of plasma cells that produce large amounts of IgG4.
Gene_expression (produce) of IgG4 in plasma cells associated with pancreatitis
1) Confidence 0.52 Published 2007 Journal JOP Section Abstract Doc Link 17495364 Disease Relevance 0.51 Pain Relevance 0.09
On the basis of established criteria, we diagnosed autoimmune pancreatitis with (1) diffuse swelling of the pancreas, (2) irregularities of the pancreatic duct, (3) lymphoplasmacytic infiltration, (4) response to corticosteroids, (5) hypergammaglobulinaemia, and (6) disproportionately raised IgG4.
Gene_expression (raised) of IgG4 in pancreatic duct associated with pressure and volume under development, corticosteroid and pancreatitis
2) Confidence 0.45 Published 2004 Journal Eur J Gastroenterol Hepatol Section Abstract Doc Link 15618835 Disease Relevance 1.70 Pain Relevance 0.31
Elevated serum IgG4 levels have been described in patients with LPSP and have been used to distinguish LPSP from pancreatic carcinoma preoperatively.
Gene_expression (levels) of IgG4 associated with pancreatic cancer and pancreatitis
3) Confidence 0.40 Published 2004 Journal Semin Diagn Pathol Section Abstract Doc Link 16273942 Disease Relevance 1.57 Pain Relevance 0.33
The development of these complications combined with the demonstration of high serum levels of IgG4 and carbonic anhydrase II led to a re-evaluation of the initial histology of the pancreas, leading to a final diagnosis of autoimmune pancreatitis: IgG4+ lymphoplasmacytic infiltrates, fibrosis, and obliterative phlebitis.
Gene_expression (levels) of IgG4 in pancreas associated with fibrosis, cv general 2 under development and pancreatitis
4) Confidence 0.09 Published 2008 Journal Rev Esp Enferm Dig Section Abstract Doc Link 19119794 Disease Relevance 1.45 Pain Relevance 0.21
The IgG and IgG4 levels of these patients were compared with those of 35 AIP patients diagnosed in Asan Medical Center.
Gene_expression (levels) of IgG4
5) Confidence 0.04 Published 2007 Journal Pancreas Section Body Doc Link 17632322 Disease Relevance 0.26 Pain Relevance 0
The anti-SWAP IgGI and IgG4 were significantly higher in patients than controls.
Gene_expression (higher) of IgG4
6) Confidence 0.03 Published 2002 Journal J Egypt Soc Parasitol Section Abstract Doc Link 12512825 Disease Relevance 0.41 Pain Relevance 0.12
Elevated serum IgG4 levels are characteristic and may be very helpful in the differential diagnosis from tumors and tumor-like lesions of the pancreas which seldom result in levels above 135 mg/dL.
Gene_expression (levels) of IgG4 in pancreas associated with cancer
7) Confidence 0.03 Published 2005 Journal Semin Diagn Pathol Section Abstract Doc Link 16939059 Disease Relevance 1.28 Pain Relevance 0.25
In addition to elevated serum IgG4 levels, IgG4 immunostaining of involved tissue is often used to support the diagnosis of AIP.
Gene_expression (levels) of IgG4 associated with pancreatitis
8) Confidence 0.03 Published 2010 Journal Dig Surg Section Abstract Doc Link 20551653 Disease Relevance 0.66 Pain Relevance 0.09
They did not find elevated serum IgG4 levels in patients with chronic pancreatitis, primary biliary cirrhosis, primary sclerosing cholangitis, nor Sjogren syndrome [6].
Spec (find) Gene_expression (levels) of IgG4 associated with biliary liver cirrhosis, sjoegrens syndrome, primary sclerosing cholangitis and chronic pancreatitis
9) Confidence 0.03 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.46 Pain Relevance 0.32
Elevated IgG4 levels in AIP
Gene_expression (levels) of IgG4 associated with pancreatitis
10) Confidence 0.03 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.50 Pain Relevance 0.38
Elevated serum IgG4 levels and positive IgG4 immunostaining have been associated not only with AIP, but also with retroperitoneal fibrosis, sialoadenitis, mediastinal adenopathy (as in the patient reported herein), cholangitis, and tubulointerstitial nephritis [3,21,22,27] and is one criterion for diagnosis in the HISORt criteria [3,5].
Gene_expression (levels) of IgG4 associated with fibrosis, interstitial nephritis, cholangitis, retroperitoneal fibrosis and pancreatitis
11) Confidence 0.03 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.18 Pain Relevance 0.14
Successful treatment of pediatric IgG4 related systemic disease with mycophenolate mofetil: case report and a review of the pediatric autoimmune pancreatitis literature

Autoimmune pancreatitis is frequently associated with elevated serum and tissue IgG4 levels in the adult population, but there are few reports of pediatric autoimmune pancreatitis, and even fewer reports of IgG4 related systemic disease in a pediatric population.

Gene_expression (levels) of IgG4 associated with pancreatitis and disease
12) Confidence 0.03 Published 2011 Journal Pediatr Rheumatol Online J Section Title Doc Link PMC3022838 Disease Relevance 1.19 Pain Relevance 0.20
In a surgical series of chronic pancreatitis cases, we determined the relative frequency of AIP before and after 1990, analyzed the diagnostic significance of IgG4 expression and examined the presence of oligoclonal T or B-cell populations.
Spec (analyzed) Gene_expression (expression) of IgG4 in B-cell associated with pancreatitis and chronic pancreatitis
13) Confidence 0.03 Published 2007 Journal Am. J. Surg. Pathol. Section Abstract Doc Link 17414098 Disease Relevance 0.93 Pain Relevance 0.27
Autoimmune pancreatitis: frequency, IgG4 expression, and clonality of T and B cells.
Gene_expression (expression) of IgG4 in B cells associated with pancreatitis
14) Confidence 0.03 Published 2007 Journal Am. J. Surg. Pathol. Section Title Doc Link 17414098 Disease Relevance 1.17 Pain Relevance 0.25
Elevated serum IgG4 levels and positive IgG4 immunostaining have been associated not only with AIP, but also with retroperitoneal fibrosis, sialoadenitis, mediastinal adenopathy (as in the patient reported herein), cholangitis, and tubulointerstitial nephritis [3,21,22,27] and is one criterion for diagnosis in the HISORt criteria [3,5].
Gene_expression (levels) of IgG4 associated with fibrosis, interstitial nephritis, cholangitis, retroperitoneal fibrosis and pancreatitis
15) Confidence 0.03 Published 2011 Journal Pediatr Rheumatol Online J Section Body Doc Link PMC3022838 Disease Relevance 1.12 Pain Relevance 0.11
All of patients had positive IgG4 levels, 40 cases were found positives for specific total IgG and 42 cases for IgG1, whereas, only 30 cases had positive IgG2 levels (66.6%).
Gene_expression (levels) of IgG4
16) Confidence 0.01 Published 2002 Journal J Egypt Soc Parasitol Section Abstract Doc Link 12214934 Disease Relevance 0.69 Pain Relevance 0.13
Also in autoimmune pancreatitis, there are increased levels of gammaglobulins and characteristically high titres of IgG4, which are a subtype of IgG.
Gene_expression (subtype) of IgG4 associated with pancreatitis
17) Confidence 0.01 Published 2005 Journal Dig Liver Dis Section Abstract Doc Link 15888288 Disease Relevance 1.37 Pain Relevance 0.15
Laboratory studies typically demonstrate elevated serum IgG4 levels and imaging studies reveal a diffusely or focally enlarged pancreas with associated diffuse or focal narrowing of the pancreatic duct.
Gene_expression (levels) of IgG4 in pancreatic duct associated with imagery
18) Confidence 0.00 Published 2007 Journal Gastroenterol. Clin. North Am. Section Abstract Doc Link 17533077 Disease Relevance 0.76 Pain Relevance 0.19
Serum IgG4 levels were elevated in seven of them.
Gene_expression (levels) of IgG4
19) Confidence 0.00 Published 2004 Journal Am. J. Gastroenterol. Section Abstract Doc Link 15447769 Disease Relevance 1.00 Pain Relevance 0.15
Thus, quantification of serum levels of anti-carbonic anhydrase II and IgG4 has greatly contributed to the diagnosis of ACP.
Gene_expression (levels) of IgG4 associated with chronic pancreatitis
20) Confidence 0.00 Published 2006 Journal Gastroenterol Hepatol Section Abstract Doc Link 16733037 Disease Relevance 0.82 Pain Relevance 0.58

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