INT10512

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.46
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 1.40
Pain Relevance 2.69

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
vasculature 2
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
cocaine 11 99.70 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 13 99.68 Very High Very High Very High
Nucleus accumbens 6 99.40 Very High Very High Very High
Morphine 14 99.12 Very High Very High Very High
Eae 3 99.12 Very High Very High Very High
Inflammatory response 3 79.04 Quite High
Angina 3 75.44 Quite High
Inflammation 5 75.00 Quite High
addiction 3 58.48 Quite High
aspirin 4 46.68 Quite Low
Disease Link Frequency Relevance Heat
Thrombosis Related Under Development 1 98.96 Very High Very High Very High
Infarction 2 98.48 Very High Very High Very High
Stroke 57 93.04 High High
Adhesions 4 90.84 High High
Myocardial Infarction 4 89.32 High High
INFLAMMATION 7 79.04 Quite High
Cv General 3 Under Development 4 75.44 Quite High
Middle Cerebral Artery Infarction 31 5.00 Very Low Very Low Very Low
Injury 6 5.00 Very Low Very Low Very Low
Death 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Genes identified had functions related to modulation of immune cells. tPA gene expression was found to be dependent on the reperfusion status of cerebral vasculature.
Positive_regulation (dependent) of Gene_expression (expression) of tPA in vasculature
1) Confidence 0.46 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC2875237 Disease Relevance 0.35 Pain Relevance 0
Psychostimulants strongly induce their expression in the mesolimbic dopaminergic pathway, but cocaine preferentially induces uPA, whereas morphine and amphetamine preferentially induce tPA. tPA-expressing animals displayed enhanced conditional place preference (CPP) for amphetamine compared with uPA-overexpressing animals.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of tPA associated with morphine and cocaine
2) Confidence 0.40 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.09 Pain Relevance 0.15
Suppression of endogenous tPA expression in animals treated with LV-siRNA fully suppresses place preference, and these animals appear to avoid the drug-associated box. tPA overexpression delays extinction, but priming with low doses of amphetamine reinstates place preference even after full extinction.
Positive_regulation (overexpression) of Gene_expression (overexpression) of tPA
3) Confidence 0.40 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0 Pain Relevance 0.08
We conclude that impairment of t-PA production is associated with acute coronary thrombosis, although it is not possible to differentiate between a causative role or a secondary response due to exhaustion of the t-PA producing mechanism.
Positive_regulation (impairment) of Gene_expression (production) of t-PA associated with thrombosis related under development
4) Confidence 0.26 Published 1992 Journal Aust N Z J Med Section Abstract Doc Link 1497553 Disease Relevance 0.67 Pain Relevance 0.08
Furthermore, animals infected with lentiviruses expressing uPA show enhanced conditional place preference for cocaine compared with tPA-overexpressing animals.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of tPA associated with cocaine
5) Confidence 0.10 Published 2008 Journal Genes Brain Behav. Section Abstract Doc Link 17680802 Disease Relevance 0 Pain Relevance 0.60
We show that tPA-overexpressing animals show greater locomotor activity and behavioral sensitization upon morphine and amphetamine treatments.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of tPA associated with eae and morphine
6) Confidence 0.10 Published 2008 Journal Genes Brain Behav. Section Abstract Doc Link 17680802 Disease Relevance 0 Pain Relevance 0.58
In contrast, tPA-overexpressing animals when administered amphetamine or morphine showed greater place preference compared with uPA-overexpressing animals.
Positive_regulation (overexpressing) of Gene_expression (overexpressing) of tPA associated with morphine
7) Confidence 0.10 Published 2008 Journal Genes Brain Behav. Section Abstract Doc Link 17680802 Disease Relevance 0 Pain Relevance 0.60
Although the levels of von Willebrand factor and plasminogen activator inhibitor-1 showed essentially the same changes in both groups during and after percutaneous transluminal coronary angioplasty, more markedly increased levels of tissue type plasminogen activator and type plasminogen activator-plasminogen activator inhibitor-1 complex after percutaneous transluminal coronary angioplasty were found in group 1 than in group 2.
Positive_regulation (increased) of Gene_expression (levels) of tissue type plasminogen activator associated with percutaneous transluminal coronary angioplasty
8) Confidence 0.04 Published 2000 Journal Thromb. Res. Section Abstract Doc Link 10822073 Disease Relevance 0.28 Pain Relevance 0.60

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox