INT10513

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.76
First Reported 1988
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 44
Total Number 45
Disease Relevance 19.49
Pain Relevance 7.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
blood 3
liver 1
vascular endothelium 1
leucocyte 1
vasculature 1
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 107 100.00 Very High Very High Very High
qutenza 2 100.00 Very High Very High Very High
bradykinin 2 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
Hyperalgesia 2 99.98 Very High Very High Very High
cocaine 16 99.70 Very High Very High Very High
Percutaneous transluminal coronary angioplasty 13 99.48 Very High Very High Very High
Nucleus accumbens 6 99.40 Very High Very High Very High
Morphine 20 99.12 Very High Very High Very High
Eae 3 99.12 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 49 100.00 Very High Very High Very High
Myocardial Infarction 25 100.00 Very High Very High Very High
Hyperalgesia 2 99.98 Very High Very High Very High
Stroke 723 99.56 Very High Very High Very High
Middle Cerebral Artery Infarction 384 99.04 Very High Very High Very High
Thrombosis Related Under Development 8 98.96 Very High Very High Very High
Infarction 9 97.92 Very High Very High Very High
Injury 82 96.60 Very High Very High Very High
Myelodysplastic Syndromes 5 96.48 Very High Very High Very High
Cv Unclassified Under Development 57 95.04 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
tPA gene expression in rats with reperfused-MCAO
Gene_expression (expression) of tPA associated with middle cerebral artery infarction
1) Confidence 0.76 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.06 Pain Relevance 0.08
tPA gene expression in rats with permanent-MCAO
Gene_expression (expression) of tPA associated with middle cerebral artery infarction
2) Confidence 0.76 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.35 Pain Relevance 0
Rats reperfused after two hours of cerebral ischemia had a different tPA gene expression profile than rats with permanent-MCAO.
Gene_expression (expression) of tPA associated with middle cerebral artery infarction, cv general 4 under development and ischemia
3) Confidence 0.76 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.25 Pain Relevance 0.22
tPA gene expression
Gene_expression (expression) of tPA
4) Confidence 0.66 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.12 Pain Relevance 0.13
Suppression of endogenous tPA expression in animals treated with LV-siRNA fully suppresses place preference, and these animals appear to avoid the drug-associated box. tPA overexpression delays extinction, but priming with low doses of amphetamine reinstates place preference even after full extinction.
Gene_expression (expression) of tPA
5) Confidence 0.62 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.05 Pain Relevance 0.09
For this purpose, animals were injected with lentiviruses expressing or silencing tPA in the NAc and place preference was assessed.
Gene_expression (expressing) of tPA
6) Confidence 0.62 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.07 Pain Relevance 0.12
When ectopic expression of tPA has been inhibited by doxycycline during acquisition, animals do no more associate the environment with the drug.
Gene_expression (expression) of tPA
7) Confidence 0.62 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.06 Pain Relevance 0.10
tPA differentially expressed 929 genes in the blood of rats (p ?
Gene_expression (expressed) of tPA in blood
8) Confidence 0.59 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC2875237 Disease Relevance 0.35 Pain Relevance 0
Genes identified had functions related to modulation of immune cells. tPA gene expression was found to be dependent on the reperfusion status of cerebral vasculature.
Gene_expression (expression) of tPA in vasculature
9) Confidence 0.59 Published 2010 Journal BMC Genomics Section Abstract Doc Link PMC2875237 Disease Relevance 0.35 Pain Relevance 0
Using a rat model of ischemic stroke, we performed gene expression analysis on whole blood samples to determine the expression profile for tPA.
Spec (determine) Gene_expression (expression) of tPA in blood associated with stroke
10) Confidence 0.59 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.17 Pain Relevance 0.09
Some genes expressed following administration of tPA interacted with ischemic stroke, with a different gene expression profile for tPA in rats with middle cerebral artery occlusion (MCAO) followed by reperfusion compared to rats with permanent-MCAO.
Gene_expression (expressed) of tPA in middle cerebral artery associated with middle cerebral artery infarction and stroke
11) Confidence 0.59 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.26 Pain Relevance 0.09
Analysis 2. tPA gene expression depends on the status of vascular reperfusion
Gene_expression (expression) of tPA
12) Confidence 0.59 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.17 Pain Relevance 0.08
Further study is required to better delineate MMP-9 mRNA expression patterns in blood, including the relationship with vascular reperfusion, duration of cerebral ischemia, treatment with tPA, and correlation with expression patterns of MMP-9 in cerebral tissue.


Gene_expression (expression) of tPA in blood associated with cv general 4 under development and ischemia
13) Confidence 0.58 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.08 Pain Relevance 0.18
tPA modulated gene expression related to the immune system.
Gene_expression (expression) of tPA in immune system
14) Confidence 0.58 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.48 Pain Relevance 0.03
Of these 533 gene probes, only 15 overlapped with gene probes expressed by tPA in rats with permanent-MCAO (Figure 2).
Gene_expression (expressed) of tPA associated with middle cerebral artery infarction
15) Confidence 0.58 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 0.89 Pain Relevance 0.07
Psychostimulants strongly induce their expression in the mesolimbic dopaminergic pathway, but cocaine preferentially induces uPA, whereas morphine and amphetamine preferentially induce tPA. tPA-expressing animals displayed enhanced conditional place preference (CPP) for amphetamine compared with uPA-overexpressing animals.
Gene_expression (expressing) of tPA associated with morphine and cocaine
16) Confidence 0.54 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.09 Pain Relevance 0.15
Psychostimulants strongly induce their expression in the mesolimbic dopaminergic pathway, but cocaine preferentially induces uPA, whereas morphine and amphetamine preferentially induce tPA. tPA-expressing animals displayed enhanced conditional place preference (CPP) for amphetamine compared with uPA-overexpressing animals.
Gene_expression (overexpressing) of tPA associated with morphine and cocaine
17) Confidence 0.54 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.09 Pain Relevance 0.15
Suppression of endogenous tPA expression in animals treated with LV-siRNA fully suppresses place preference, and these animals appear to avoid the drug-associated box. tPA overexpression delays extinction, but priming with low doses of amphetamine reinstates place preference even after full extinction.
Gene_expression (overexpression) of tPA
18) Confidence 0.54 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0 Pain Relevance 0.08
We found that tPA expression is associated with acquisition of place preference and animals overexpressing tPA spend >87% of the time in the drug-associated compartment, compared with 60% for control animals.
Gene_expression (expression) of tPA
19) Confidence 0.54 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.07 Pain Relevance 0.11
Evaluation of the acute hemodynamic effects and pharmacokinetics of coronary thrombolysis produced by intravenous tissue-type plasminogen activator in the anesthetized dog.
Gene_expression (produced) of tissue-type plasminogen activator associated with anesthesia
20) Confidence 0.50 Published 1988 Journal J. Cardiovasc. Pharmacol. Section Title Doc Link 2464103 Disease Relevance 0.28 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox