INT10514

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Context Info
Confidence 0.47
First Reported 1992
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.22
Pain Relevance 2.24

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Plat) extracellular space (Plat) extracellular region (Plat)
molecular_function (Plat) cytoplasm (Plat)
Anatomy Link Frequency
blood 2
vascular endothelium 2
Plat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 18 100.00 Very High Very High Very High
qutenza 2 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
bradykinin 2 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
narcan 1 94.52 High High
Angina 2 90.68 High High
Opioid 1 90.32 High High
Glutamate 5 90.00 High High
antinociception 3 86.92 High High
Disease Link Frequency Relevance Heat
Cv General 4 Under Development 10 100.00 Very High Very High Very High
Hyperalgesia 2 100.00 Very High Very High Very High
Middle Cerebral Artery Infarction 93 99.96 Very High Very High Very High
Thrombosis Related Under Development 6 98.96 Very High Very High Very High
Myocardial Infarction 8 98.72 Very High Very High Very High
Infarction 4 98.48 Very High Very High Very High
Stroke 171 96.84 Very High Very High Very High
Cv Unclassified Under Development 9 95.04 Very High Very High Very High
Cv General 3 Under Development 5 90.68 High High
Pain 2 86.08 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When ectopic expression of tPA has been inhibited by doxycycline during acquisition, animals do no more associate the environment with the drug.
Negative_regulation (inhibited) of Gene_expression (expression) of tPA
1) Confidence 0.47 Published 2008 Journal Neuropsychopharmacology Section Abstract Doc Link 18256596 Disease Relevance 0.06 Pain Relevance 0.10
Analysis 2. tPA gene expression depends on the status of vascular reperfusion
Negative_regulation (depends) of Gene_expression (expression) of tPA
2) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.18 Pain Relevance 0.08
tPA gene expression in rats with reperfused-MCAO
Negative_regulation (reperfused) of Gene_expression (expression) of tPA associated with middle cerebral artery infarction
3) Confidence 0.42 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.07 Pain Relevance 0.08
Further study is required to better delineate MMP-9 mRNA expression patterns in blood, including the relationship with vascular reperfusion, duration of cerebral ischemia, treatment with tPA, and correlation with expression patterns of MMP-9 in cerebral tissue.


Negative_regulation (delineate) of Gene_expression (expression) of tPA in blood associated with cv general 4 under development and ischemia
4) Confidence 0.37 Published 2010 Journal BMC Genomics Section Body Doc Link PMC2875237 Disease Relevance 1.08 Pain Relevance 0.18
We conclude that impairment of t-PA production is associated with acute coronary thrombosis, although it is not possible to differentiate between a causative role or a secondary response due to exhaustion of the t-PA producing mechanism.
Negative_regulation (impairment) of Gene_expression (production) of t-PA associated with thrombosis related under development
5) Confidence 0.22 Published 1992 Journal Aust N Z J Med Section Abstract Doc Link 1497553 Disease Relevance 0.67 Pain Relevance 0.08
Reduced synthesis of tissue plasminogen activator by vascular endothelium during acute myocardial infarction.
Negative_regulation (Reduced) of Gene_expression (synthesis) of tissue plasminogen activator in vascular endothelium associated with myocardial infarction
6) Confidence 0.22 Published 1992 Journal Aust N Z J Med Section Title Doc Link 1497553 Disease Relevance 0.66 Pain Relevance 0.09
Interestingly, the i.p. administration of alpha,beta-amyrin reduced the mechanical hyperalgesia produced by i.pl. injection of carrageenan, capsaicin, bradykinin, substance P, prostaglandin E2, 8-Br-cAMP, and TPA in rats.
Negative_regulation (reduced) of Gene_expression (produced) of TPA associated with hyperalgesia, qutenza, bradykinin and substance p
7) Confidence 0.07 Published 2005 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 15626726 Disease Relevance 0.69 Pain Relevance 1.56
Levels of tissue plasminogen activator decreased in both groups, but the reduction was smaller in the NuvaRing group.
Negative_regulation (decreased) of Gene_expression (Levels) of tissue plasminogen activator
8) Confidence 0.02 Published 2010 Journal International Journal of Women's Health Section Body Doc Link PMC2990910 Disease Relevance 0.76 Pain Relevance 0.06

General Comments

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