INT105148

Context Info Confidence 0.50 First Reported 2002 Last Reported 2010 Negated 2 Speculated 1 Reported most in Body Documents 6 Total Number 8 Disease Relevance 6.45 Pain Relevance 1.80

signal transduction (TNC) extracellular space (TNC) extracellular region (TNC) cell adhesion (TNC)

Anatomy Link Frequency articular 4 arm 2 TNC (Homo sapiens)

Pain Link Frequency Relevance Heat Inflammation 135 99.72 fluoxetine 5 98.96 Snapping jaw 6 91.56 Chronic pancreatitis 1 88.36 metalloproteinase 7 83.68 cytokine 28 78.08 Paracetamol 2 73.60 rheumatoid arthritis 14 70.60 fibrosis 1 67.20 Multiple sclerosis 11 60.76

Disease Link Frequency Relevance Heat Arthritis 12 99.96 Mental Disorders 72 98.64 Tendinopathy 5 98.64 INFLAMMATION 139 98.00 Pancreatic Cancer 3 97.92 Cancer 32 97.32 Dermatofibroma 10 96.88 Disease 77 94.76 Necrosis 7 93.96 Temporomandibular Joint Syndrome 6 91.56

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

However, we were able to find tenascin mRNA expression in the surgical specimens.

Spec (find) Positive_regulation (find) of Gene_expression (expression) of tenascin

1) Confidence 0.50 Published 2002 Journal J Oral Rehabil Section Abstract Doc Link 12220344 Disease Relevance 0.57 Pain Relevance 0.52

Major molecular changes include increased expression of type III collagen, fibronectin, tenascin C, aggrecan and biglycan.

Positive_regulation (increased) of Gene_expression (expression) of tenascin C

2) Confidence 0.49 Published 2008 Journal Nature clinical practice. Rheumatology Section Abstract Doc Link 18235537 Disease Relevance 0.48 Pain Relevance 0.06

Intra-articular injection of the TLR4 activators FNEDA or tenascin-C induces joint inflammation in wild type but not in TLR4 null mice [24, 86].

Positive_regulation (activators) of Gene_expression (injection) of tenascin-C in articular associated with inflammation and arthritis

3) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.59 Pain Relevance 0.49

Intra-articular injection of the TLR4 activators FNEDA or tenascin-C induces joint inflammation in wild type but not in TLR4 null mice [24, 86].

Neg (not) Positive_regulation (induces) of Gene_expression (injection) of tenascin-C in articular associated with inflammation and arthritis

4) Confidence 0.49 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2913853 Disease Relevance 1.59 Pain Relevance 0.49

Several studies have shown that there is increased expression of tenascin at the dermal-epidermal junction overlying the spindle cell proliferation in DF, but not in DFSP.

Positive_regulation (increased) of Gene_expression (expression) of tenascin associated with dermatofibroma

5) Confidence 0.38 Published 2010 Journal World J Surg Oncol Section Body Doc Link PMC2892497 Disease Relevance 1.12 Pain Relevance 0.04

In conclusion, the expression of TNC and cell surface annexin II increases in the progression from low-grade PanIN lesions to pancreatic cancer.

Positive_regulation (increases) of Gene_expression (expression) of TNC associated with pancreatic cancer

6) Confidence 0.31 Published 2006 Journal J. Pathol. Section Abstract Doc Link 16450333 Disease Relevance 0.93 Pain Relevance 0.09

They will have only one additional staff, viz. the Health Assistant, who will screen patients for CMD, and fluoxetine will be provided by the project to PHCs but not to private GP practices, as in the Collaborative Stepped Care arm.

Neg (not) Positive_regulation (private) of Gene_expression (practices) of GP in arm associated with mental disorders and fluoxetine

7) Confidence 0.06 Published 2008 Journal Trials Section Body Doc Link PMC2265673 Disease Relevance 0.10 Pain Relevance 0.12

The transition from GP to OP1 was less pronounced in terms of both a maximum ?

Positive_regulation (transition) of Gene_expression (transition) of GP

8) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2864763 Disease Relevance 0.07 Pain Relevance 0

General Comments

This test has worked.