INT105157

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.48
Pain Relevance 6.38

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (Gfap) extracellular matrix organization (Gfap) cytoplasm (Gfap)
Anatomy Link Frequency
masseter 6
astrocyte 4
microglia 2
hippocampus 2
Gfap (Rattus norvegicus)
Pain Link Frequency Relevance Heat
nMDA receptor 62 100.00 Very High Very High Very High
Inflammation 330 99.98 Very High Very High Very High
Glutamate 53 99.88 Very High Very High Very High
Hyperalgesia 427 96.56 Very High Very High Very High
Lasting pain 53 95.64 Very High Very High Very High
nMDA receptor antagonist 12 95.20 Very High Very High Very High
Hippocampus 2 95.12 Very High Very High Very High
Analgesic 6 93.76 High High
Morphine 13 92.88 High High
Duloxetine 11 91.84 High High
Disease Link Frequency Relevance Heat
INFLAMMATION 364 99.98 Very High Very High Very High
Injury 85 97.96 Very High Very High Very High
Nociception 35 97.52 Very High Very High Very High
Hyperalgesia 427 96.56 Very High Very High Very High
Pain 141 95.64 Very High Very High Very High
Dermatitis 10 94.60 High High
Neuropathic Pain 76 89.04 High High
Temporomandibular Joint Syndrome 19 76.32 Quite High
Facial Pain 15 60.04 Quite High
Cancer 10 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present work we show that glutamate also stimulates GFAP phosphorylation in microslices prepared from immature cerebellar cortex, but by a different receptor mechanism from that observed in the hippocampus.
Positive_regulation (stimulates) of Phosphorylation (phosphorylation) of GFAP in hippocampus associated with glutamate and hippocampus
1) Confidence 0.67 Published 2002 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 12220706 Disease Relevance 0 Pain Relevance 0.38
In previous work we showed that phosphorylation of glial fibrillary acidic protein (GFAP), an astrocyte marker, is increased by glutamate in hippocampal slices from immature rats via a type II metabotropic receptor.
Positive_regulation (increased) of Phosphorylation (phosphorylation) of GFAP in astrocyte associated with glutamate
2) Confidence 0.48 Published 2002 Journal Brain Res. Dev. Brain Res. Section Abstract Doc Link 12220706 Disease Relevance 0 Pain Relevance 0.30
Western blot data showed that masseter inflammation induced an enhanced NMDA receptor phosphorylation and upregulation of GFAP in both Vi/Vc and Vc zones, while cutaneous inflammation only induced similar effects in the caudal Vc.
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GFAP in masseter associated with inflammation and nmda receptor
3) Confidence 0.38 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.39 Pain Relevance 1.12
NMDA receptor expression and phosphorylation were upregulated, as well as GFAP and CD11b, markers of astroglia and microglia, respectively.
Positive_regulation (upregulated) of Phosphorylation (phosphorylation) of GFAP in microglia associated with nmda receptor
4) Confidence 0.36 Published 2010 Journal Mol Pain Section Body Doc Link PMC2914030 Disease Relevance 0.90 Pain Relevance 1.31
We have shown that masseter inflammation induced a significant increase in NMDA receptor NR1 subunit phosphorylation and GFAP levels in the Vi/Vc transition zone [17].
Positive_regulation (increase) of Phosphorylation (phosphorylation) of GFAP in masseter associated with inflammation and nmda receptor
5) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.95 Pain Relevance 0.73
We have shown that masseter inflammation induced a significant increase in NMDA receptor NR1 subunit phosphorylation and GFAP levels in the Vi/Vc transition zone [17].
Positive_regulation (induced) of Phosphorylation (phosphorylation) of GFAP in masseter associated with inflammation and nmda receptor
6) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 0.96 Pain Relevance 0.73
Injection of CFA into the masseter produced significant increases in N-methyl-D-aspartate (NMDA) receptor NR1 serine 896 phosphorylation and glial fibrillary acidic protein (GFAP) levels, a marker of reactive astrocytes, in Vi/Vc and caudal Vc.
Positive_regulation (increases) of Phosphorylation (phosphorylation) of GFAP in astrocytes
7) Confidence 0.35 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2806354 Disease Relevance 1.20 Pain Relevance 0.95
In contrast, injection of CFA into the cutaneous site only produced an increase in NMDA receptor phosphorylation (Fig. 8A right) and GFAP (Fig. 8B right) levels in the Vc without an effect in Vi/Vc.


Positive_regulation (increase) of Phosphorylation (phosphorylation) of GFAP associated with nmda receptor
8) Confidence 0.35 Published 2009 Journal Mol Pain Section Body Doc Link PMC2806354 Disease Relevance 1.09 Pain Relevance 0.85

General Comments

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