INT105162

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Context Info
Confidence 0.12
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 47
Total Number 47
Disease Relevance 46.53
Pain Relevance 1.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
E1a 11
liver 3
interdigitating cell 2
ganglion cell layer 1
spleen 1
Ad (Mus musculus)
Pain Link Frequency Relevance Heat
anesthesia 43 97.92 Very High Very High Very High
fifth nerve 6 97.92 Very High Very High Very High
Analgesic 3 97.86 Very High Very High Very High
imagery 166 95.32 Very High Very High Very High
Calcitonin gene-related peptide 16 93.56 High High
trigeminal ganglion 6 91.60 High High
Spinal cord 12 91.56 High High
cytokine 133 90.24 High High
Inflammation 97 86.88 High High
Potency 62 85.20 High High
Disease Link Frequency Relevance Heat
Cancer 2221 100.00 Very High Very High Very High
Cytomegalovirus Infection 820 100.00 Very High Very High Very High
Infection 459 100.00 Very High Very High Very High
Influenza Virus Infection 217 100.00 Very High Very High Very High
Herpes Simplex Virus 4 100.00 Very High Very High Very High
Sprains And Strains 213 99.76 Very High Very High Very High
Apoptosis 480 99.66 Very High Very High Very High
Pneumonia 39 99.62 Very High Very High Very High
Ganglion Cysts 32 99.60 Very High Very High Very High
Hepatitis 37 99.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, liver glycogen was significantly reduced in Ad-shPck1–treated animals on fasting (Table 1), consistent with decreased hepatic glucose production capacity
Gene_expression (reduced) of Ad-shPck1 in liver
1) Confidence 0.12 Published 2008 Journal Diabetes Section Body Doc Link PMC2494684 Disease Relevance 0.23 Pain Relevance 0.03
Mice were resuscitated using atipamazole (IP) and administered buprinex (SQ) as an analgesic. 17 d after tumor implantation and using the same stereotactic coordinates, mice received an intratumoral injection of either 1 × 108 IU Ad0, 5 × 107 IU Ad-Flt3L + 5 × 107 IU Ad0, 5 × 107 IU Ad-TK + 5 × 107 IU Ad0, or 5 × 107 IU Ad-Flt3L + 5 × 107 IU Ad-TK in 1 ?
Gene_expression (injection) of Ad0 associated with cancer and analgesic
2) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.65 Pain Relevance 0.13
Figure 9A–9D reveals statistically significant increases (*p < 0.05 versus mock and Ad0) in HMGB1 levels in the supernatants of GL26 (?
Gene_expression (mock) of Ad0
3) Confidence 0.11 Published 2009 Journal PLoS Medicine Section Body Doc Link PMC2621261 Disease Relevance 0.71 Pain Relevance 0
A375 or B16 cells infected with Ad-hTERT-E1a-Apoptin, Ad-CMV-E1a-Apoptin, Ad-hTERT-E1a and Ad-CMV-E1a produced E1a proteins (36 kDa); however, cells infected with Ad-hTERT-Apoptin, Ad-CMV-Apoptin or Ad-mock did not (Figure 1B and 1C).
Gene_expression (produced) of Ad-hTERT-E1a in E1a associated with cytomegalovirus infection
4) Confidence 0.09 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.17 Pain Relevance 0
However, it is clear from the mean survival results that the mice given Ad-CMV-E1a-Apoptin or Ad-hTERT-E1a-Apoptin showed the longest survival.
Gene_expression (given) of Ad-hTERT-E1a in E1a associated with cytomegalovirus infection
5) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.65 Pain Relevance 0
In A375 and B16 cells, infection with the adenoviruses expressing Apoptin were observed predominantly in a late apoptotic stage; however, infection with Ad-CMV-E1a or Ad-hTERT-E1a were seen in mainly an early apoptotic stage.
Gene_expression (infection) of Ad-hTERT-E1a in E1a associated with cytomegalovirus infection, apoptosis and infection
6) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.43 Pain Relevance 0
Systemic delivery of Ad-hTERT-E1a-Apoptin suppressed solid melanoma growth
Gene_expression (delivery) of Ad-hTERT-E1a in E1a associated with melanoma
7) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.36 Pain Relevance 0
Although the infection of Ad-hTERT-E1a-Apoptin did not lead to complete elimination of the tumors, effective inhibition was observed in both primary and metastatic tumor models.
Gene_expression (infection) of Ad-hTERT-E1a in E1a associated with cancer, metastasis and infection
8) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 1.73 Pain Relevance 0
These results demonstrated that Ad-hTERT-E1a-Apoptin had cancer cell-selective replication properties, and the Apoptin transgene was effectively expressed.


Gene_expression (expressed) of Ad-hTERT-E1a in E1a associated with cancer
9) Confidence 0.08 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.18 Pain Relevance 0
A two-dose schedule (0, 6 months) of a hepatitis B vaccine (Engerix-B™: Adult formulation, GlaxoSmithKline [GSK] Biologicals, Belgium) has been approved for use in European adolescents and is also one of the recommended schedules for vaccination of adolescents aged 11-15 years in Australia [10], United States and Canada.
Gene_expression (formulation) of Adult associated with hepatitis
10) Confidence 0.07 Published 2010 Journal BMC Infect Dis Section Body Doc Link PMC3016379 Disease Relevance 0.82 Pain Relevance 0
In the HEM cell line, infection with Ad-CMV-Apoptin, Ad-hTERT-E1a-Apoptin and Ad-CMV-E1a-Apoptin, but not Ad-hTERT-Apoptin, Ad-hTERT-E1a, Ad-CMV-E1a or Ad-mock, produced Apoptin protein (Figure 1D).
Gene_expression (produced) of Ad-hTERT-E1a in E1a associated with cytomegalovirus infection and infection
11) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.16 Pain Relevance 0
In the HEM cell line, infection with Ad-CMV-Apoptin, Ad-hTERT-E1a-Apoptin and Ad-CMV-E1a-Apoptin, but not Ad-hTERT-Apoptin, Ad-hTERT-E1a, Ad-CMV-E1a or Ad-mock, produced Apoptin protein (Figure 1D).
Gene_expression (produced) of Ad-hTERT-Apoptin in E1a associated with cytomegalovirus infection and infection
12) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.08 Pain Relevance 0
In the HEM cell line, infection with Ad-CMV-Apoptin, Ad-hTERT-E1a-Apoptin and Ad-CMV-E1a-Apoptin, but not Ad-hTERT-Apoptin, Ad-hTERT-E1a, Ad-CMV-E1a or Ad-mock, produced Apoptin protein (Figure 1D).
Gene_expression (produced) of Ad-hTERT-E1a in E1a associated with cytomegalovirus infection and infection
13) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.07 Pain Relevance 0
A375 or B16 cells infected with Ad-hTERT-E1a-Apoptin, Ad-CMV-E1a-Apoptin, Ad-hTERT-E1a and Ad-CMV-E1a produced E1a proteins (36 kDa); however, cells infected with Ad-hTERT-Apoptin, Ad-CMV-Apoptin or Ad-mock did not (Figure 1B and 1C).
Gene_expression (infected) of Ad-hTERT-E1a in A375 associated with cytomegalovirus infection
14) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.12 Pain Relevance 0
Ad-hTERT-E1a-Apoptin suppressed subcutaneous primary tumor growth
Gene_expression (suppressed) of Ad-hTERT-E1a in E1a associated with cancer
15) Confidence 0.07 Published 2010 Journal Mol Cancer Section Body Doc Link PMC2818692 Disease Relevance 2.56 Pain Relevance 0
Animals were routinely fed ad libitum on a diet including fresh banana (393 kJ/100 g) and a homemade milky mixture containing baby cereals, eggs and milk (435 kJ/100 g).
Gene_expression (fed) of ad libitum in eggs
16) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2761491 Disease Relevance 0 Pain Relevance 0
As in our previous series, because of adCre diffusion through the CSF circulation, spinal meningiomas (n = 3) were found in adCre;Nf2flox2/flox2;Ink4a*/* mice and spinal MRI was performed in two mice presenting with paraparesis, a neurological signs suggestive of spinal cord compression (Figure 5A,C).
Gene_expression (diffusion) of adCre in spinal associated with meningioma, paraparesis, imagery and spinal cord
17) Confidence 0.06 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.39 Pain Relevance 0.34
We used first generation, recombinant adenoviral vectors (serotype 5) expressing Herpes Simplex Virus Type I Thymidine Kinase (Ad-TK) [27], [29] and Fms-like tyrosine kinase 3 ligand (Ad-Flt3L)[28], [49] in this study.
Gene_expression (expressing) of Ad-TK associated with fibromyalgia and herpes simplex virus
18) Confidence 0.05 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2291560 Disease Relevance 0.53 Pain Relevance 0
The other mice were fed ad libitum with high-fat (HF, Research Diet no. 12492: 60% calories from fat, 20% from carbohydrate, and 20% from protein; 5.24?
Gene_expression (fed) of ad libitum in fat
19) Confidence 0.05 Published 2010 Journal Journal of Obesity Section Body Doc Link PMC3017904 Disease Relevance 0.16 Pain Relevance 0.11
Diagnostic ultrastructural features of meningioma, including interdigitating cell processes and desmosomal intercellular junctions, were found in one adCre;Nf2flox2/flox22;Ink4a*/* mouse meningioma analyzed by electron microscopy (Figure 1D,E).
Gene_expression (found) of adCre in interdigitating cell associated with meningioma
20) Confidence 0.05 Published 2008 Journal Brain Pathology (Zurich, Switzerland) Section Body Doc Link PMC2253711 Disease Relevance 1.24 Pain Relevance 0

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