INT105171

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.74
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 11
Total Number 11
Disease Relevance 2.33
Pain Relevance 4.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (RAF1) cytoplasm (RAF1) cytosol (RAF1)
cell proliferation (RAF1) signal transduction (RAF1) nucleus (RAF1)
Anatomy Link Frequency
CHO 2
neurons 1
RAF1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 68 100.00 Very High Very High Very High
agonist 216 99.68 Very High Very High Very High
Calcium channel 56 98.54 Very High Very High Very High
opioid receptor 9 96.48 Very High Very High Very High
Inflammation 12 95.52 Very High Very High Very High
cINOD 1 94.00 High High
withdrawal 6 93.80 High High
Central nervous system 1 93.04 High High
MU agonist 9 85.00 Quite High
Opioid 9 74.20 Quite High
Disease Link Frequency Relevance Heat
Carcinoid 9 99.10 Very High Very High Very High
Leukemia 13 95.92 Very High Very High Very High
INFLAMMATION 13 95.52 Very High Very High Very High
Skin Cancer 21 86.84 High High
Prostate Cancer 13 86.48 High High
Disease 13 83.92 Quite High
Syndrome 1 83.36 Quite High
Metastasis 1 80.80 Quite High
Neuroendocrine Cancer 1 78.68 Quite High
Breast Cancer 27 77.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Treatment of carcinoid tumor cells with ZM336372 resulted in progressive phosphorylation of Raf-1, mitogen-activated protein kinase 1/2, and extracellular signal-regulated kinase 1/2.
Phosphorylation (phosphorylation) of Raf-1 associated with carcinoid
1) Confidence 0.74 Published 2005 Journal Mol. Cancer Ther. Section Abstract Doc Link 15956248 Disease Relevance 0.97 Pain Relevance 0.06
Raf-1 in turn phosphorylates and sensitizes the native adenylyl cyclase VI isoenzyme in hDOR/CHO cells, causing a rebound increase in forskolin-stimulated cAMP formation upon agonist withdrawal.
Phosphorylation (phosphorylates) of Raf-1 associated with agonist and withdrawal
2) Confidence 0.52 Published 2003 Journal Life Sci. Section Abstract Doc Link 14607258 Disease Relevance 0.05 Pain Relevance 0.85
Since phosphorylation of adenylyl cyclase VI by Raf-1 protein kinase was recently shown, we tested the role of Raf-1 in adenylyl cyclase superactivation in hDOR/CHO cells.
Phosphorylation (phosphorylation) of Raf-1 in CHO
3) Confidence 0.45 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12223234 Disease Relevance 0 Pain Relevance 0.40
Because we showed previously that the Raf-1 inhibitor 3-(3,5-dibromo-4-hydroxybenzylidene-5-iodo-1,3-dihydro-indol-2-one (GW5074) attenuates AC superactivation, we hypothesize that parallel calmidazolium-, chelerythrine-, and genistein-sensitive pathways converge at Raf-1 to mediate AC superactivation by phosphorylating AC VI in hDOR/CHO cells.
Phosphorylation (phosphorylating) of Raf-1 in CHO
4) Confidence 0.45 Published 2003 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12660310 Disease Relevance 0 Pain Relevance 0.38
Cell differentiation is dependent on phosphorylation of Raf1 46.
Phosphorylation (phosphorylation) of Raf1
5) Confidence 0.40 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.08 Pain Relevance 0.14
agonists stimulated the phosphorylation of PKC, Raf-1 and AKT.
Phosphorylation (phosphorylation) of Raf-1 associated with kinase c and agonist
6) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.56
PKC stimulates the ERK/MAPK and AKT pathway by phosphorylating and activating Raf-1 and AKT [85].
Phosphorylation (phosphorylating) of Raf-1 associated with kinase c
7) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.55
The activation of these pathways in neurons from mES cells is dependent on calcium mobilization from L-type VGCC, because nifedipine blocks the increase in calcium oscillations and the phosphorylation of PKC, Raf-1 and AKT.
Phosphorylation (phosphorylation) of Raf-1 in neurons associated with kinase c and calcium channel
8) Confidence 0.11 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.43
The activated PKC can then phosphorylate Raf-1 and AKT activating the MAPK and AKT pathways.
Phosphorylation (phosphorylate) of Raf-1 associated with kinase c
9) Confidence 0.08 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2910705 Disease Relevance 0 Pain Relevance 0.55
These effects appear in part Gq-dependent (Billington and Penn, unpublished observations) and may be mediated by the capacity of Gq signaling to stimulate the p42/p44 MAPK (via PKC-mediated phosphorylation of Raf-1) and p70S6K pathways and therefore induce promitogenic transcription factor activation, cyclin D1 induction, and upregulate the translational machinery necessary for cell cycle progression [36,37].
Phosphorylation (phosphorylation) of Raf-1 associated with kinase c
10) Confidence 0.08 Published 2003 Journal Respir Res Section Body Doc Link PMC152647 Disease Relevance 0 Pain Relevance 0.15
The phosphorylation levels of Raf-1 and ERKs were dramatically increased in BDNF-transfected hUCB-MSCs at 7 days of induction (Figure 8C).


Phosphorylation (phosphorylation) of Raf-1
11) Confidence 0.07 Published 2010 Journal BMC Biotechnol Section Body Doc Link PMC2883955 Disease Relevance 0.22 Pain Relevance 0.12

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox