INT105181

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Context Info
Confidence 0.33
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 10
Total Number 10
Disease Relevance 4.06
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Hist1h3f) molecular_function (Hist1h3f) biological_process (Hist1h3f)
Anatomy Link Frequency
stem cells 1
Hist1h3f (Mus musculus)
Pain Link Frequency Relevance Heat
Kappa opioid receptor 9 98.72 Very High Very High Very High
Hippocampus 58 86.88 High High
chemokine 9 77.04 Quite High
Opioid 1 66.40 Quite High
member 8 1 63.16 Quite High
palliative 2 50.72 Quite High
dexamethasone 4 31.28 Quite Low
tolerance 1 20.52 Low Low
fibrosis 18 5.00 Very Low Very Low Very Low
Central nervous system 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Mantle-cell Lymphoma 1 99.80 Very High Very High Very High
Cognitive Disorder 7 99.50 Very High Very High Very High
Cancer 123 98.32 Very High Very High Very High
Stomach Cancer 115 98.04 Very High Very High Very High
Follicular Lymphoma 1 97.24 Very High Very High Very High
Apoptosis 94 96.28 Very High Very High Very High
Targeted Disruption 18 96.20 Very High Very High Very High
Lymphatic System Cancer 22 86.68 High High
Death 20 83.08 Quite High
Convulsion 44 82.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, chromatin immunoprecipitation demonstrated reduced c-myc binding to the E boxes and hypoacetylation of histone H3 on the chromatin of endogenous KOR promoters in P19 stem cells treated with SNP.
Positive_regulation (hypoacetylation) of histone H3 in stem cells associated with kappa opioid receptor
1) Confidence 0.33 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.07 Pain Relevance 0.42
Both eyeblink classical conditioning (EBCC) and object recognition memory (ORM) induced an increase in histone H3 acetylation (Ac-H3).
Positive_regulation (increase) of histone H3 associated with cognitive disorder
2) Confidence 0.24 Published 2008 Journal Mol. Cell. Neurosci. Section Abstract Doc Link 18638560 Disease Relevance 0.26 Pain Relevance 0.05
Second, we observed a profound decrease in cell proliferation as measured by staining for the phosphorylated Histone H3 (HH3, Figures 2C & 2D; group effect: F3,11?
Positive_regulation (measured) of Histone H3
3) Confidence 0.20 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2396793 Disease Relevance 0.39 Pain Relevance 0
In addition, the maximal increase of p21WAF1 was detected concomitant with activation of acetyl-histone H3.
Positive_regulation (activation) of acetyl-histone H3
4) Confidence 0.19 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.24 Pain Relevance 0
Such rapid tubulin acetylation occurred in parallel with increases in acetyl-histone H3 and p21WAF1.


Positive_regulation (increases) of acetyl-histone H3
5) Confidence 0.14 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.44 Pain Relevance 0
VPA increased the acetylation of histone H3, resulting in a significant reduction of tumor growth through induction of both p21WAF1 and apoptosis.
Positive_regulation (increased) of histone H3 associated with cancer and apoptosis
6) Confidence 0.13 Published 2010 Journal J Exp Clin Cancer Res Section Body Doc Link PMC2994814 Disease Relevance 0.72 Pain Relevance 0
binding is accompanied by an increase in histone H3 acetylation and histone 3 lysine 4 trimethylation (H3K4me3), two markers of transcriptional activation, while histone 3 lysine 9 dimethylation (H3K9me2), a marker that signifies transcription silencing, decreased [43].
Positive_regulation (increase) of histone H3
7) Confidence 0.10 Published 2010 Journal PPAR Research Section Body Doc Link PMC2943104 Disease Relevance 0.05 Pain Relevance 0
An increase in the acetylation levels of histone H3 with a maximum effect 8 h after dosing could be seen, but also only in the 200-mg cohort.
Positive_regulation (increase) of histone H3
8) Confidence 0.08 Published 2010 Journal Clinical Epigenetics Section Body Doc Link PMC3020651 Disease Relevance 0.99 Pain Relevance 0
In vitro treatment with CXCL12 did not increase phospho-histone H3 levels or alter nestin or ?
Neg (not) Positive_regulation (increase) of phospho-histone H3
9) Confidence 0.03 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3013129 Disease Relevance 0.29 Pain Relevance 0.15
In addition, chromatin immunoprecipitation assays showed that acetylation of histone H3 in the 5' region of the gene correlated directly with SLC5A8 expression and inversely with DNA methylation.
Positive_regulation (acetylation) of histone H3
10) Confidence 0.02 Published 2004 Journal Tumour Biol. Section Abstract Doc Link 15361710 Disease Relevance 0.60 Pain Relevance 0.06

General Comments

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