INT105185

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Context Info
Confidence 0.42
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 3.53
Pain Relevance 7.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Oprk1) plasma membrane (Oprk1) signal transducer activity (Oprk1)
Anatomy Link Frequency
spinal cord 4
nucleus accumbens 2
fibroblast 2
nucleus 2
BLA 2
Oprk1 (Mus musculus)
Pain Link Frequency Relevance Heat
opioid receptor 292 100.00 Very High Very High Very High
Pain 124 100.00 Very High Very High Very High
Kappa opioid receptor 104 100.00 Very High Very High Very High
Spinal cord 39 100.00 Very High Very High Very High
Locus ceruleus 7 100.00 Very High Very High Very High
Ventral tegmentum 2 99.68 Very High Very High Very High
Morphine 64 99.40 Very High Very High Very High
Raphe 3 99.40 Very High Very High Very High
dorsal root ganglion 47 99.12 Very High Very High Very High
Raphe magnus 3 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 121 100.00 Very High Very High Very High
Embryonal Carcinoma 1 100.00 Very High Very High Very High
Ganglion Cysts 74 99.12 Very High Very High Very High
Rheumatoid Arthritis 6 97.84 Very High Very High Very High
Urological Neuroanatomy 17 97.40 Very High Very High Very High
Osteoarthritis 3 96.84 Very High Very High Very High
INFLAMMATION 213 95.44 Very High Very High Very High
Disease 18 84.56 Quite High
Neuropathic Pain 32 81.32 Quite High
Sleep Disorders 15 80.44 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
KOR was constitutively expressed in postnatal day 19 (P19) embryonal carcinoma stem cells and is suppressed by NO donors [sodium nitroprusside (SNP), 3-morpholinosydnonimine-1, and S-nitrosoglutathione] in P19 stem cells within 4 hr.
Negative_regulation (suppressed) of Gene_expression (expressed) of KOR in stem cells associated with kappa opioid receptor and embryonal carcinoma
1) Confidence 0.42 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223547 Disease Relevance 0.10 Pain Relevance 0.22
Brain opioid systems have been implicated in the regulation of social interaction, including agonistic behaviour. kappa-Opioid receptor B and C mRNA levels were decreased in the ventral tegmental area but not in the nucleus accumbens in male mice with repeated experience of social victories (winners), but not in mice after social defeats (losers) after 10 but not 20 days of confrontations. mu-Opioid receptor mRNA levels were not changed.
Negative_regulation (decreased) of Gene_expression (levels) of kappa-Opioid receptor B in nucleus accumbens associated with nucleus accumbens, ventral tegmentum, opioid receptor and opioid
2) Confidence 0.41 Published 2005 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 15857692 Disease Relevance 0.07 Pain Relevance 0.37
CONCLUSION: Kappa opioid receptor activation decreases synaptic transmission and inhibits the induction of LTP in the BLA of the mouse.
Negative_regulation (inhibits) of Gene_expression (activation) of Kappa opioid receptor in BLA
3) Confidence 0.40 Published 2009 Journal Eur J Pain Section Body Doc Link 18439862 Disease Relevance 0 Pain Relevance 0
KOR activation in the ipsilateral TREZ was blocked by the deletion of KOR or by NorBNI treatment (Fig. 5D, E, F).
Negative_regulation (blocked) of Gene_expression (deletion) of KOR associated with kappa opioid receptor
4) Confidence 0.37 Published 2010 Journal Mol Pain Section Body Doc Link PMC2826348 Disease Relevance 0.34 Pain Relevance 0.98
The expression of KOR increased in the locus ceruleus and spinal cord, but was significantly decreased in the DRG of morphine tolerant rats (P<0.05).
Negative_regulation (decreased) of Gene_expression (expression) of KOR in spinal cord associated with locus ceruleus, kappa opioid receptor, morphine and spinal cord
5) Confidence 0.14 Published 2010 Journal Brain Res. Section Abstract Doc Link 20206145 Disease Relevance 0.19 Pain Relevance 2.36
More specifically, the expression of KOR and DOR have recently been shown to be decreased in the fibroblast-like synoviocytes of patients with rheumatoid arthritis and osteoarthritis, particularly where inflammation was present (Shen et al 2005).
Negative_regulation (decreased) of Gene_expression (expression) of KOR in fibroblast associated with inflammation, rheumatoid arthritis and osteoarthritis
6) Confidence 0.08 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 1.04 Pain Relevance 0.84
In independent studies, KOR expression has been found to both decrease and remain static in DRG (Ji et al 1995; Zhang et al 1998), and remain constant in the spinal cord (Ji et al 1995).
Negative_regulation (decrease) of Gene_expression (expression) of KOR in spinal cord associated with dorsal root ganglion and spinal cord
7) Confidence 0.06 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.97 Pain Relevance 0.66
Accordingly, MOR, DOR, and KOR expression has been confirmed in dorsal root ganglia, the spinal cord, and trigeminal nucleus of the ascending pain pathway as well as the central Gray area, pontine, gigantocellulare, and intermediate reticular nuclei of the descending pain pathway, with predominantly MOR and KOR expression in the median raphe and raphe magnus (Mansour et al 1988).
Negative_regulation (nucleus) of Gene_expression (expression) of KOR in nucleus associated with raphe magnus, pain, raphe and spinal cord
8) Confidence 0.06 Published 2005 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC1661636 Disease Relevance 0.54 Pain Relevance 1.93
The data showed that Grb7 knockdown reduced the effect of EGF on KOR expression, which was rescued by expressing siRNA-insensitive Flag-Grb7 (see Materials and methods).
Negative_regulation (reduced) of Gene_expression (expression) of KOR
9) Confidence 0.02 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2819679 Disease Relevance 0.27 Pain Relevance 0.17

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