INT105194

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Context Info
Confidence 0.56
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 11
Disease Relevance 3.05
Pain Relevance 14.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
spinal cord dorsal horn 3
neuronal 2
spinal 1
nerve 1
synaptic vesicles 1
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 201 100.00 Very High Very High Very High
excitatory amino acid 17 99.92 Very High Very High Very High
tolerance 21 99.90 Very High Very High Very High
opioid receptor 10 99.90 Very High Very High Very High
dexamethasone 20 99.74 Very High Very High Very High
Antinociceptive 19 99.70 Very High Very High Very High
Pain 58 99.64 Very High Very High Very High
Spinal cord 70 99.48 Very High Very High Very High
Morphine 89 99.10 Very High Very High Very High
Dorsal horn 20 99.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Pain 67 99.64 Very High Very High Very High
Nervous System Injury 30 99.56 Very High Very High Very High
Neuropathic Pain 44 98.80 Very High Very High Very High
Hyperalgesia 20 95.40 Very High Very High Very High
Nociception 28 90.92 High High
INFLAMMATION 24 50.00 Quite Low
Injury 3 42.24 Quite Low
Anxiety Disorder 1 18.88 Low Low
Ganglion Cysts 8 5.00 Very Low Very Low Very Low
Hypersensitivity 5 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The downregulation of EAAC1 was significantly diminished after either the GR antagonist RU38486 (4 > 2 = 0.5 microg = vehicle) or a GR antisense oligonucleotide was administered intrathecally twice daily for postoperative day 1-6.
Negative_regulation (downregulation) of EAAC1 associated with antagonist
1) Confidence 0.56 Published 2006 Journal Pain Section Abstract Doc Link 16360273 Disease Relevance 0.59 Pain Relevance 0.55
Here we show that the downregulation of spinal GTs (EAAC1 and GLT-1) induced by a 6-day intrathecal morphine (10 microg, twice daily) treatment regimen was prevented by co-administration of morphine with 2',5'-dideoxyadenosine (ddA, 1 microg, a broad adenylyl cyclase inhibitor) or H89 (10 microg, a selective protein kinase A inhibitor).
Negative_regulation (downregulation) of EAAC1 in spinal associated with morphine and intrathecal
2) Confidence 0.50 Published 2005 Journal Neurosci. Lett. Section Abstract Doc Link 15694265 Disease Relevance 0.06 Pain Relevance 0.73
The results showed that amitriptyline alone did not produce an antinociceptive effect, while morphine alone induced antinociceptive tolerance and down-regulation of spinal glutamate transporters (GLAST, GLT-1, and EAAC1) in the rat spinal cord dorsal horn.
Negative_regulation (down-regulation) of EAAC1 in spinal cord dorsal horn associated with glutamate, dorsal horn, tolerance, antinociceptive, endep, spinal cord and morphine
3) Confidence 0.47 Published 2006 Journal Pain Section Abstract Doc Link 16697108 Disease Relevance 0 Pain Relevance 1.72
Downregulation of spinal glutamate transporter EAAC1 following nerve injury is regulated by central glucocorticoid receptors in rats.
Negative_regulation (Downregulation) of EAAC1 in nerve associated with glutamate and nervous system injury
4) Confidence 0.36 Published 2006 Journal Pain Section Title Doc Link 16360273 Disease Relevance 0.56 Pain Relevance 0.47
Chronic morphine administered through either intrathecal boluses or continuous infusion induced a dose-dependent downregulation of GTs (EAAC1 and GLAST) in the rat's superficial spinal cord dorsal horn.
Negative_regulation (downregulation) of EAAC1 in spinal cord dorsal horn associated with dorsal horn, spinal cord, intrathecal and morphine
5) Confidence 0.36 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223586 Disease Relevance 0.48 Pain Relevance 1.66
The results suggest that DOR can reduce EAAC1 function by direct protein-protein interaction and that activation of DOR releases the inhibitory interaction.
Negative_regulation (reduce) of EAAC1 associated with opioid receptor
6) Confidence 0.33 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16882010 Disease Relevance 0 Pain Relevance 0.70
Long-term morphine infusion induced antinociceptive tolerance and down-regulation of glutamate transporters (GTs), GLAST, GLT-1, and EAAC1, expression in the rat spinal cord dorsal horn.
Negative_regulation (down-regulation) of EAAC1 in spinal cord dorsal horn associated with glutamate, dorsal horn, tolerance, antinociceptive, spinal cord and morphine
7) Confidence 0.30 Published 2007 Journal Pain Section Abstract Doc Link 17346885 Disease Relevance 0 Pain Relevance 1.62
DEX co-infusion prevented the downregulation of glial glutamate transporters (GLAST (Glu-Asp transporter) and GLT-1 (Glu transporter-1)), but not the neuronal GT EAAC1 (excitatory amino acid carrier).
Negative_regulation (downregulation) of EAAC1 in neuronal associated with glutamate, dexamethasone and excitatory amino acid
8) Confidence 0.28 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893883 Disease Relevance 0 Pain Relevance 2.03
DEX co-infusion prevented the downregulation of glial glutamate transporters (GLAST (Glu-Asp transporter) and GLT-1 (Glu transporter-1)), but not the neuronal GT EAAC1 (excitatory amino acid carrier).
Negative_regulation (prevented) of EAAC1 in neuronal associated with glutamate, dexamethasone and excitatory amino acid
9) Confidence 0.28 Published 2005 Journal Neuroscience Section Abstract Doc Link 15893883 Disease Relevance 0 Pain Relevance 2.04
Reduction of glutamate uptake activity via GLAST and EAAC1 may contribute to the maintenance of neuropathic pain.
Negative_regulation (Reduction) of EAAC1 associated with glutamate and neuropathic pain
10) Confidence 0.21 Published 2008 Journal Mol Pain Section Body Doc Link PMC2628654 Disease Relevance 1.11 Pain Relevance 1.31
Third, inhibition of reuptake through presynaptic EAAC1 and/or the glutamate/glutamine cycle in the spinal cord might result in a depletion of glutamate in synaptic vesicles and a decrease in presynaptically released glutamate, leading to a reduction in glutamate receptor-mediated nociceptive transmission.
Negative_regulation (inhibition) of EAAC1 in synaptic vesicles associated with nociception, glutamate, glutamate receptor and spinal cord
11) Confidence 0.21 Published 2005 Journal Mol Pain Section Body Doc Link PMC1274343 Disease Relevance 0.25 Pain Relevance 1.36

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