INT105195

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Context Info
Confidence 0.40
First Reported 2002
Last Reported 2006
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 0.48
Pain Relevance 3.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc1a1)
Anatomy Link Frequency
spinal cord dorsal horn 4
Slc1a1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tolerance 11 100.00 Very High Very High Very High
Glutamate 9 100.00 Very High Very High Very High
Antinociceptive 4 100.00 Very High Very High Very High
Morphine 24 99.86 Very High Very High Very High
Spinal cord 3 99.48 Very High Very High Very High
intrathecal 2 99.36 Very High Very High Very High
Dorsal horn 2 99.00 Very High Very High Very High
Endep 9 98.58 Very High Very High Very High
Thermal hyperalgesia 4 96.40 Very High Very High Very High
opioid receptor 1 91.52 High High
Disease Link Frequency Relevance Heat
Hyperalgesia 6 96.40 Very High Very High Very High
Pain 3 88.48 High High
INFLAMMATION 1 25.00 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The results showed that amitriptyline alone did not produce an antinociceptive effect, while morphine alone induced antinociceptive tolerance and down-regulation of spinal glutamate transporters (GLAST, GLT-1, and EAAC1) in the rat spinal cord dorsal horn.
Positive_regulation (induced) of Negative_regulation (down-regulation) of EAAC1 in spinal cord dorsal horn associated with glutamate, dorsal horn, tolerance, antinociceptive, endep, spinal cord and morphine
1) Confidence 0.40 Published 2006 Journal Pain Section Abstract Doc Link 16697108 Disease Relevance 0 Pain Relevance 1.73
Chronic morphine administered through either intrathecal boluses or continuous infusion induced a dose-dependent downregulation of GTs (EAAC1 and GLAST) in the rat's superficial spinal cord dorsal horn.
Positive_regulation (induced) of Negative_regulation (downregulation) of EAAC1 in spinal cord dorsal horn associated with dorsal horn, spinal cord, intrathecal and morphine
2) Confidence 0.31 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12223586 Disease Relevance 0.48 Pain Relevance 1.67

General Comments

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