INT10520

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Context Info
Confidence 0.24
First Reported 1992
Last Reported 2010
Negated 4
Speculated 0
Reported most in Abstract
Documents 20
Total Number 20
Disease Relevance 10.15
Pain Relevance 20.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
RVM 8
neuronal 3
medial 2
tail 1
projection neurons 1
Rvm (Mus musculus)
Pain Link Frequency Relevance Heat
Rostral ventromedial medulla 325 100.00 Very High Very High Very High
medulla 33 100.00 Very High Very High Very High
Serotonin 19 100.00 Very High Very High Very High
Rostroventromedial medulla 11 100.00 Very High Very High Very High
Pain 143 99.98 Very High Very High Very High
analgesia 34 99.92 Very High Very High Very High
Central grey 13 99.92 Very High Very High Very High
Glutamate 19 99.78 Very High Very High Very High
amygdala 13 99.68 Very High Very High Very High
Cannabinoid 22 99.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 103 100.00 Very High Very High Very High
Pain 160 99.98 Very High Very High Very High
Urological Neuroanatomy 60 99.92 Very High Very High Very High
Arthritis 11 99.28 Very High Very High Very High
Ganglion Cysts 5 98.96 Very High Very High Very High
Neuropathic Pain 99 97.76 Very High Very High Very High
Nervous System Injury 163 95.48 Very High Very High Very High
Hyperalgesia 61 94.44 High High
INFLAMMATION 61 93.80 High High
Hypoalagesia 3 92.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Opioid action within the medial and cortical nuclei also influenced RVM cell activity, but did not prevent the reflex-related OFF cell pause, and failed to alter the tail flick substantially.
Neg (failed) Regulation (influenced) of RVM in medial associated with tail-flick, opioid and rostral ventromedial medulla
1) Confidence 0.24 Published 2002 Journal Pain Section Abstract Doc Link 11932071 Disease Relevance 0.17 Pain Relevance 1.36
Surprisingly, and despite the consistent changes in RVM cell activity, the prolonged noxious stimulus caused different effects depending on the reflex used to assess nociception.
Regulation (changes) of RVM in RVM associated with nociception and rostral ventromedial medulla
2) Confidence 0.24 Published 1994 Journal J. Neurophysiol. Section Abstract Doc Link 7807201 Disease Relevance 0.39 Pain Relevance 0.57
Phenylephrine dose-dependently increased mean arterial pressure and tail flick latency, but had inconsistent effects on neural activity in the RVM.
Regulation (effects) of RVM in RVM associated with medulla and tail-flick
3) Confidence 0.24 Published 1996 Journal Brain Res. Section Abstract Doc Link 8738257 Disease Relevance 0.41 Pain Relevance 0.81
This suggests that in terms of activity at least, if not number, descending facilitations are the predominant RVM influence that impacts the spinal cord in normal animals.
Regulation (influence) of RVM in RVM associated with spinal cord and rostral ventromedial medulla
4) Confidence 0.24 Published 2007 Journal Neuroscience Section Abstract Doc Link 17570596 Disease Relevance 0.16 Pain Relevance 0.74
Morphine applied within the central, medial lateral and dorsal lateral nuclei had no effect on RVM neurons or on the tail flick.
Neg (no) Regulation (effect) of RVM in tail associated with tail-flick, rostral ventromedial medulla and morphine
5) Confidence 0.24 Published 2002 Journal Pain Section Abstract Doc Link 11932071 Disease Relevance 0.17 Pain Relevance 1.35
Microinjection of morphine into various amygdaloid nuclei differentially affects nociceptive responsiveness and RVM neuronal activity.
Regulation (affects) of RVM in neuronal associated with nociception, nociceptor and morphine
6) Confidence 0.24 Published 2002 Journal Pain Section Title Doc Link 11932071 Disease Relevance 0.29 Pain Relevance 0.89
These data thus demonstrate that the previously described reflex-related changes in RVM neuron activity are not specific to barbiturate-anesthetized preparations, and that a failure to demonstrate off-cells in some studies may result from these neurons being inactive following repeated testing with noxious stimuli.
Regulation (changes) of RVM in neurons associated with rostral ventromedial medulla
7) Confidence 0.22 Published 1992 Journal Brain Res. Section Abstract Doc Link 1498677 Disease Relevance 0.07 Pain Relevance 0.41
Lidocaine in the PVN increased ON-cell firing in control animals and decreased OFF-cell firing in arthritic animals, while glutamate failed to affect activity of RVM cells.
Neg (failed) Regulation (affect) of RVM in RVM associated with rostroventromedial medulla, glutamate, lidocaine and arthritis
8) Confidence 0.20 Published 2008 Journal Brain Res. Section Abstract Doc Link 18242585 Disease Relevance 0.98 Pain Relevance 1.50
It was also shown that the immediate-early gene c-fos was up-regulated in the RVM following formalin injection into the hind paw and that this was reduced by lamina I/III lesions [36].
Regulation (regulated) of RVM in lamina associated with rostral ventromedial medulla
9) Confidence 0.16 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 0.74 Pain Relevance 0.97
In Experiment 2, the effects of i.v. serotonin on neural activity in the RVM in intact and cardiopulmonary deafferented rats were determined.
Regulation (effects) of RVM in RVM associated with medulla and serotonin
10) Confidence 0.13 Published 1999 Journal Physiol. Behav. Section Abstract Doc Link 10604848 Disease Relevance 0.34 Pain Relevance 1.05
We also show that endogenous cannabinoids tonically regulate pain thresholds in part through the modulation of RVM neuronal activity.
Regulation (modulation) of RVM in neuronal associated with pain, cannabinoid and rostral ventromedial medulla
11) Confidence 0.10 Published 1998 Journal Nature Section Abstract Doc Link 9759727 Disease Relevance 0.32 Pain Relevance 1.76
Furthermore, cannabinoids produce analgesia by modulating RVM neuronal activity in a manner similar to, but pharmacologically dissociable from, that of morphine.
Regulation (modulating) of RVM in RVM associated with cannabinoid, morphine, rostral ventromedial medulla and analgesia
12) Confidence 0.10 Published 1998 Journal Nature Section Abstract Doc Link 9759727 Disease Relevance 0.33 Pain Relevance 1.75
Intra-ventrolateral PAG (S)-3,4-dicarboxyphenylglycine [(S)-3,4-DCPG (2 and 4 nmol/rat)] or N,N(I)-dibenzhydrylethane-1,2-diamin dihydrochloride (AMN082, (1 and 2 nmol/rat), selective mGluR(8) and mGluR(7) agonists, respectively, caused opposite effects on the ongoing RVM on and off cell activities.
Regulation (effects) of RVM in RVM associated with agonist, central grey and rostral ventromedial medulla
13) Confidence 0.10 Published 2007 Journal J. Neurophysiol. Section Abstract Doc Link 17507496 Disease Relevance 0.63 Pain Relevance 0.85
Descending controls from the RVM are indirectly modulated by activity in ascending pathways originating in lamina I/III projection neurons of the dorsal horn.
Regulation (modulated) of RVM in projection neurons associated with dorsal horn, projection neuron and rostral ventromedial medulla
14) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.30 Pain Relevance 1.46
It seems likely that the changing postnatal influence of the RVM in spinal nociception and the late development of the PAG-RVM connection [11,41] may account for the failure of SNI to promote mechanical hyperalgesia in neonates following peripheral nerve injury.
Regulation (influence) of RVM in peripheral nerve associated with nociception, hyperalgesia, nervous system injury, urological neuroanatomy, peripheral nerve injury and rostral ventromedial medulla
15) Confidence 0.10 Published 2010 Journal Mol Pain Section Body Doc Link PMC2945971 Disease Relevance 1.27 Pain Relevance 0.95
Microinjections of morphine into the basolateral (BLa) and medial (MEa) nuclei of the amygdala differentially affect rostral ventromedial medulla (RVM) neuronal activity and nocifensive behaviors.
Regulation (affect) of RVM in medial associated with amygdala, rostral ventromedial medulla and morphine
16) Confidence 0.08 Published 2004 Journal Brain Res. Section Abstract Doc Link 15120601 Disease Relevance 0.17 Pain Relevance 0.70
These observations provide evidence that both ON and OFF cells in the RVM are targeted by noradrenergic inputs.
Regulation (targeted) of RVM in RVM associated with rostral ventromedial medulla
17) Confidence 0.05 Published 1997 Journal J. Comp. Neurol. Section Abstract Doc Link 8989653 Disease Relevance 0.16 Pain Relevance 0.13
These effects were prevented by pre-treatment with I-RTX at a dose which did not significantly change the ongoing RVM ON and OFF cell activities per se.
Neg (not) Regulation (change) of RVM associated with rostral ventromedial medulla
18) Confidence 0.04 Published 2010 Journal Mol Pain Section Body Doc Link PMC2959024 Disease Relevance 0.66 Pain Relevance 1.09
Microinjection of capsaicin likely sensitized and then desensitized dPAG neurons affecting nocifensive reflexes and RVM neuronal activity.
Regulation (affecting) of RVM in neuronal associated with qutenza and rostral ventromedial medulla
19) Confidence 0.03 Published 2003 Journal J. Neurophysiol. Section Abstract Doc Link 12815018 Disease Relevance 0.44 Pain Relevance 0.94
The presence of high levels of NTS1 mRNA and proteins in regions implicated in pain regulation such as the RVM, PAG, lumbar dorsal root ganglion (DRG) and spinal cord neurons also suggests the role of NTS1 in nociceptive modulation [16,35-39].
Regulation (regulation) of RVM in spinal cord neurons associated with nociception, ganglion cysts, dorsal root ganglion, pain, rostroventromedial medulla, central grey and spinal cord
20) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2714839 Disease Relevance 1.16 Pain Relevance 1.26

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