INT105200

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.31
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 6
Total Number 7
Disease Relevance 2.46
Pain Relevance 1.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Ntf3) cytoplasmic membrane-bounded vesicle (Ntf3)
Ntf3 (Mus musculus)
Pain Link Frequency Relevance Heat
neurotrophin 3 5 100.00 Very High Very High Very High
Nerve growth factor 120 99.16 Very High Very High Very High
bDMF 9 88.32 High High
induced neuropathy 4 88.04 High High
Pain 2 83.96 Quite High
Inflammation 13 58.28 Quite High
cytokine 8 55.36 Quite High
qutenza 1 38.88 Quite Low
Arthritis 3 28.24 Quite Low
Inflammatory response 4 23.36 Low Low
Disease Link Frequency Relevance Heat
Neurodegenerative Disease 18 99.04 Very High Very High Very High
Neuropathy 8 98.76 Very High Very High Very High
Hereditary Sensory And Autonomic Neuropathies 4 98.36 Very High Very High Very High
Sprains And Strains 4 95.00 High High
Toxicity 8 91.92 High High
Neuropathic Pain 6 88.04 High High
Pain 2 83.96 Quite High
Necrosis 3 80.12 Quite High
Cancer 4 79.76 Quite High
Death 18 58.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Similar effects were observed in cisplatin-treated mice that received intramuscular injections of a plasmid encoding NT-3 associated with in vivo electroporation.
NT-3 Binding (associated) of
1) Confidence 0.31 Published 2002 Journal Gene Ther. Section Abstract Doc Link 12224017 Disease Relevance 0.41 Pain Relevance 0.31
NT3 was the only growth factor that showed a high association with adult hippocampal neurogenesis in a screen for genes associated with adult neurogenesis in a set of recombinant inbred strains of mice [39].
NT3 Binding (association) of associated with neurotrophin 3, sprains and strains and neurodegenerative disease
2) Confidence 0.21 Published 2007 Journal PLoS ONE Section Body Doc Link PMC1849968 Disease Relevance 0.43 Pain Relevance 0.23
As the interaction of NT3 and TrkA temporally and spatially precedes the interaction of NGF with TrkA, we examined the signaling of NT3 in a CIPA-associated TrkA mutant.
NT3 Spec (examined) Binding (interaction) of associated with nerve growth factor
3) Confidence 0.19 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20188729 Disease Relevance 0.54 Pain Relevance 0.27
Second, we envision that CIPA/HSAN IV polyneuropathies might fall into two different subgroups: one with diminished NT3/TrkAII signaling, in which axons actually do not reach their targets, and a second group with sufficient NT3/TrkAII signaling but diminished NGF/TrkAII signaling, in which axons do reach their targets, yet degenerate after successful target engagement.
NT3 Neg (not) Binding (targets) of associated with neuropathy, nerve growth factor and hereditary sensory and autonomic neuropathies
4) Confidence 0.15 Published 2010 Journal Exp. Neurol. Section Abstract Doc Link 20188729 Disease Relevance 0.53 Pain Relevance 0.26
Therefore, while not a investigative focus in this work, the phosphorylation of Akt was utilized simply as a read-out to determine if BMSC could respond to neurotrophin binding to the Trk receptors.
neurotrophin Binding (binding) of
5) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2837737 Disease Relevance 0.11 Pain Relevance 0.08
NGF binds the TrkA receptor, BDNF and NT-4/5 bind the TrkB receptor, and NT-3 primarily binds the TrkC receptor [5].
NT-3 Binding (binds) of associated with nerve growth factor
6) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.22 Pain Relevance 0.23
NGF binds the TrkA receptor, BDNF and NT-4/5 bind the TrkB receptor, and NT-3 primarily binds the TrkC receptor [5].
NT-3 Binding (bind) of associated with nerve growth factor
7) Confidence 0.06 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2604901 Disease Relevance 0.22 Pain Relevance 0.28

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox