INT105210

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Context Info
Confidence 0.06
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.09
Pain Relevance 0.50

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Adrm1) nucleus (Adrm1) cytoplasm (Adrm1)
Anatomy Link Frequency
arm 6
head 1
Adrm1 (Mus musculus)
Pain Link Frequency Relevance Heat
Eae 5 95.24 Very High Very High Very High
alcohol 7 86.80 High High
antidepressant 4 86.72 High High
fluoxetine 1 82.64 Quite High
depression 3 69.84 Quite High
antagonist 1 59.40 Quite High
headache 4 12.08 Low Low
Pain 1 9.60 Low Low
Inflammation 26 5.00 Very Low Very Low Very Low
Kinase C 18 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 23 100.00 Very High Very High Very High
Proteinuria 18 100.00 Very High Very High Very High
Nose Bleeds 2 100.00 Very High Very High Very High
Hematuria 1 100.00 Very High Very High Very High
Anxiety Disorder 69 98.96 Very High Very High Very High
Renal Cancer 38 89.52 High High
Death 6 89.32 High High
Neutropenia 24 87.60 High High
Fever 11 84.40 Quite High
Solid Tumor 7 81.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The anxiolytic drugs diazepam (0.03-3 mg/kg i.p.), chlordiazepoxide (0.3-10 mg/kg i.p.), and buspirone (0.3-30 mg/kg s.c.) increased open arm exploration and produced anxiolytic-like effects on risk-assessment behaviors (reduced stretch-attend postures and increased head dips).
Positive_regulation (increased) of arm in head associated with anxiety disorder
1) Confidence 0.06 Published 2002 Journal Neuropsychopharmacology Section Abstract Doc Link 12225693 Disease Relevance 0.76 Pain Relevance 0.26
CaMKIV-/- mice spent significantly more time in the open arms of the plus-maze (Fig. 1b; P < 0.001) and displayed an increase in the number of open arm visits (Fig. 1a; P < 0.01) when compared to wild-type mice.
Positive_regulation (increase) of arm in arms
2) Confidence 0.04 Published 2005 Journal Mol Pain Section Body Doc Link PMC1208947 Disease Relevance 0.49 Pain Relevance 0.12
In the high-dose arm, epistaxis (8%), hypertension (14%; grade 3: 8%), hematuria (5%), and proteinuria (25%; grade 3: 3%) were all significantly increased from the placebo.
Positive_regulation (increased) of arm in arm associated with nose bleeds, proteinuria, cv unclassified under development and hematuria
3) Confidence 0.02 Published 2010 Journal OncoTargets and therapy Section Body Doc Link PMC2962304 Disease Relevance 1.79 Pain Relevance 0.03
Median OS was significantly longer in the TPF arm compared with the PF arm (71 months vs 30 months; HR: 0.70; 95% CI: 0.54–0.90; p = 0.006), with survival rates at 1, 2, and 3 years and pre- and post-CCRT response rates (RRs) also higher in the TPF arm (Table 3).
Positive_regulation (higher) of arm in arm
4) Confidence 0.01 Published 2008 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2621396 Disease Relevance 0.55 Pain Relevance 0
CD4+ cell counts increased steadily and modestly over 48 weeks in the non-HU arm, whereas they decreased slightly in the HU arm as a whole, fell markedly below baseline in subjects who started HU at the beginning of the study, and increased modestly between Weeks 8 and 40 in subjects who started HU at study week 8 (Fig. 5) Median change from baseline in CD4+ cell count in the non-HU and HU arms was +94 cells/mm3 and -17 cells/mm3 (P = 0.028), respectively, at week 24, and +114 cells/mm3 and -63 cells/mm3 (P = 0.007), respectively, at week 48.
Positive_regulation (increased) of arm in arm
5) Confidence 0.01 Published 2005 Journal BMC Infect Dis Section Body Doc Link PMC1090576 Disease Relevance 0.25 Pain Relevance 0
The intake of soluble fiber increased 5-fold in the PED arm at 8 weeks and 12 weeks but only 1.5-fold in the MED arm.
Positive_regulation (increased) of arm in arm
6) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 0.12 Pain Relevance 0.04
The intake of soluble fiber increased 5-fold in the PED arm at 8 weeks and 12 weeks but only 1.5-fold in the MED arm.
Positive_regulation (increased) of arm in arm
7) Confidence 0.01 Published 2008 Journal Nutr Metab (Lond) Section Body Doc Link PMC2588603 Disease Relevance 0.12 Pain Relevance 0.04

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