INT105215

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Context Info
Confidence 0.53
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 16
Total Number 20
Disease Relevance 9.42
Pain Relevance 5.97

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Pou4f1) DNA binding (Pou4f1)
Anatomy Link Frequency
dorsal root ganglion 3
neurons 2
sensory neurons 1
retinas 1
nociceptors 1
Pou4f1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 177 100.00 Very High Very High Very High
Pain 23 100.00 Very High Very High Very High
trigeminal ganglion 657 99.84 Very High Very High Very High
opioid receptor 13 97.56 Very High Very High Very High
dorsal root ganglion 3 97.52 Very High Very High Very High
vanilloid receptor subtype 1 6 95.52 Very High Very High Very High
Somatostatin 33 94.04 High High
mu opioid receptor 20 88.92 High High
Neurotransmitter 17 85.88 High High
calcitonin gene related peptide 55 84.84 Quite High
Disease Link Frequency Relevance Heat
Ganglion Cysts 761 99.84 Very High Very High Very High
Death 37 98.96 Very High Very High Very High
Targeted Disruption 311 98.24 Very High Very High Very High
Optic Nerve Injuries 12 94.16 High High
Neurodegenerative Disease 42 90.80 High High
Optic Disorders 18 83.84 Quite High
Nociception 19 83.76 Quite High
Ocular Hypertension 309 81.20 Quite High
Glaucoma 39 77.72 Quite High
Adhesions 4 65.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Together, our data suggest that nociceptors and low-threshold mechanoreceptors with medium-sized to large cell bodies may be sensitive to the loss of Brn-3a.
Negative_regulation (loss) of Brn-3a in mechanoreceptors associated with nociceptor
1) Confidence 0.53 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12225879 Disease Relevance 0.47 Pain Relevance 0.44
ETV1 expression in these neurons was largely unaffected by loss of Brn3a (Figure 2D, F).
Negative_regulation (loss) of Brn3a in neurons
2) Confidence 0.50 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.69 Pain Relevance 0.12
Loss of Brn3a also resulted in significant changes in the expression of other transcription factors.
Negative_regulation (Loss) of Brn3a
3) Confidence 0.50 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.35 Pain Relevance 0.03
Axotomized RGCs are known to undergo downregulation of the Brn3a gene [49,50] shortly before they die.
Negative_regulation (downregulation) of Brn3a
4) Confidence 0.44 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.09 Pain Relevance 0.06
However, in recent studies we have used locus-ChIP to demonstrate that Brn3a is a direct repressor of NeuroD1 and NeuroD4 in the embryonic TG [[27] in press], as well as a negative modulator of its own expression [32,33].
Negative_regulation (repressor) of Brn3a associated with trigeminal ganglion
5) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.54 Pain Relevance 0.20
Expression of the acid-sensing receptor Accn3/DRASIC, also found in a range of large and small sensory neurons in the TG [42], is Runx1-independent in the DRG and was markedly decreased in the Brn3a-/- TG (Figure 3B).
Negative_regulation (decreased) of Brn3a in sensory neurons associated with trigeminal ganglion
6) Confidence 0.42 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 1.10 Pain Relevance 0.80
Nearly complete loss of Runx3 in the Brn3a-/- TG from the time of normal onset of its expression is suggestive of direct regulation.
Negative_regulation (loss) of Brn3a associated with trigeminal ganglion
7) Confidence 0.42 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.61 Pain Relevance 0.36
Runx1-mediated effects are not sufficient to explain the loss of TrkA expression in the Brn3a-/- TG.
Negative_regulation (loss) of Brn3a associated with trigeminal ganglion
8) Confidence 0.42 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.66 Pain Relevance 0.50
Correction for cell loss using Islet1 to identify surviving neurons within the ganglion showed that the proportion of cells in the ganglion positive for Runx1 was reduced from 34 ± 3% to 18 ± 3% (Figure 2L), demonstrating a specific reduction in Runx1 expression in the absence of Brn3a.
Negative_regulation (absence) of Brn3a in ganglion associated with ganglion cysts
9) Confidence 0.42 Published 2010 Journal Neural Dev Section Body Doc Link PMC2829025 Disease Relevance 0.73 Pain Relevance 0.42
In each case, the mean effect of the loss of one Brn3a allele on target gene expression was 16% to 19% of the effect of the loss of both alleles, compared to the 50% change that would be expected without any compensatory mechanism, indicating significant but incomplete compensation for gene dosage.


Negative_regulation (loss) of Brn3a
10) Confidence 0.42 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.29 Pain Relevance 0.07
Effect of Brn-3a deficiency on nociceptors and low-threshold mechanoreceptors in the trigeminal ganglion.
Negative_regulation (deficiency) of Brn-3a in trigeminal ganglion associated with ganglion cysts, trigeminal ganglion and nociceptor
11) Confidence 0.39 Published 2002 Journal Brain Res. Mol. Brain Res. Section Title Doc Link 12225879 Disease Relevance 0.48 Pain Relevance 0.64
Three target genes, Foxd3, Isl1, and Pou4f1, are known to be repressed by Lbx1 [9], [30] and appear in Table 1.
Negative_regulation (repressed) of Pou4f1
12) Confidence 0.38 Published 2008 Journal PLoS ONE Section Body Doc Link PMC2527684 Disease Relevance 0 Pain Relevance 0
In addition, the loss of Brn3a effectively eliminates expression of all Pou4 class factors in both the DRG and TG, making selective redundancy unlikely.
Negative_regulation (loss) of Brn3a associated with trigeminal ganglion
13) Confidence 0.36 Published 2007 Journal Neural Develop Section Body Doc Link PMC1796875 Disease Relevance 0.44 Pain Relevance 0.18
Injured RGCs are known to undergo early functional deficits [17,36-38], including alterations in their axoplasmic flow properties [26,39-43], in several metabolic functions such as diminutions of their Thy-1 mRNA levels [36,44-46], or induction of phagocytic activity in microglia [47,48], and in the regulation of a substantial number of genes [49,50] including the downregulation of Brn3a [51] shortly before cell death.
Negative_regulation (downregulation) of Brn3a in microglia associated with death
14) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.95 Pain Relevance 0
The left LP retinas examined 8 and 35 days after lasering showed 24,343 (±5,739; n=12) and 10,219 (±8,887; n=9) Brn3a-labeled RGCs, respectively.
Negative_regulation (showed) of Brn3a-labeled in retinas
15) Confidence 0.28 Published 2009 Journal Molecular Vision Section Body Doc Link PMC2790482 Disease Relevance 0.13 Pain Relevance 0
On the other hand, the loss of Brn-3a caused a decrease in the number of sst2A receptor- or delta-opioid receptor-immunoreactive neurons (more than 95% reduction) and an increase in the number of mu-opioid receptor-immunoreactive neurons (9.3-fold increase).
Negative_regulation (loss) of Brn-3a in neurons associated with opioid receptor
16) Confidence 0.25 Published 2005 Journal Neurosci. Res. Section Abstract Doc Link 15740807 Disease Relevance 0.50 Pain Relevance 0.95
The present study suggests that Brn-3a deficiency may have effects on the survival of trigeminal nociceptors and their expression of some neurochemical substances.
Negative_regulation (deficiency) of Brn-3a in nociceptors associated with nociceptor
17) Confidence 0.25 Published 2005 Journal Neurosci. Res. Section Abstract Doc Link 15740807 Disease Relevance 0.35 Pain Relevance 0.67
Brn-3a deficiency increases tyrosine hydroxylase-immunoreactive neurons in the dorsal root ganglion.
Negative_regulation (deficiency) of Brn-3a in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and nociceptor
18) Confidence 0.24 Published 2005 Journal Brain Res. Section Title Doc Link 15725417 Disease Relevance 0.35 Pain Relevance 0.25
TH-immunoreactive (-IR) neurons were detected in the DRG of wild-type and heterozygous mice, but their proportion was greatly increased by the loss of Brn-3a function (wild-type and heterozygot, 8.4%; knockout, 20.9%).
Negative_regulation (loss) of Brn-3a in DRG associated with targeted disruption
19) Confidence 0.24 Published 2005 Journal Brain Res. Section Abstract Doc Link 15725417 Disease Relevance 0.35 Pain Relevance 0.04
Brn-3a deficiency increases tyrosine hydroxylase-immunoreactive neurons in the dorsal root ganglion.
Negative_regulation (deficiency) of Brn-3a in dorsal root ganglion associated with ganglion cysts, dorsal root ganglion and nociceptor
20) Confidence 0.18 Published 2005 Journal Brain Res. Section Title Doc Link 15725417 Disease Relevance 0.35 Pain Relevance 0.25

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