INT105216

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Context Info
Confidence 0.61
First Reported 2002
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 12
Disease Relevance 4.12
Pain Relevance 4.93

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Trpv2) plasma membrane (Trpv2) intracellular (Trpv2)
transmembrane transport (Trpv2) cytoplasm (Trpv2)
Anatomy Link Frequency
myocytes 1
neurons 1
gut 1
peritoneal macrophages 1
Trpv2 (Mus musculus)
Pain Link Frequency Relevance Heat
trigeminal ganglion 6 99.60 Very High Very High Very High
antagonist 152 98.88 Very High Very High Very High
agonist 133 98.88 Very High Very High Very High
nociceptor 236 97.28 Very High Very High Very High
qutenza 121 95.88 Very High Very High Very High
Neuropathic pain 30 95.08 Very High Very High Very High
Pain 392 94.88 High High
TRP channel 21 94.04 High High
Inflammation 84 93.84 High High
Thermal hyperalgesia 39 93.08 High High
Disease Link Frequency Relevance Heat
Pressure And Volume Under Development 7 99.64 Very High Very High Very High
Ganglion Cysts 80 99.60 Very High Very High Very High
Neuropathic Pain 88 95.08 Very High Very High Very High
Pain 404 94.88 High High
INFLAMMATION 81 93.84 High High
Hyperalgesia 137 93.08 High High
Nociception 99 90.24 High High
Urticaria 4 89.80 High High
Disease 69 89.44 High High
Coronary Heart Disease 5 88.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recently, 2-aminoethoxydiphenyl borate was introduced as a TRPV3 agonist, but its selectivity was questioned by showing that it activated recombinant TRPV1 and TRPV2 as well.
Positive_regulation (activated) of TRPV2 associated with agonist
1) Confidence 0.61 Published 2005 Journal Neuroscience Section Abstract Doc Link 16165301 Disease Relevance 0.07 Pain Relevance 0.40
Although BAA activated TRPV4 channels with an EC(50) of 790-950 nm, it did not activate or block activation of TRPV1, TRPV2, or TRPV3 channels.
Positive_regulation (activation) of TRPV2
2) Confidence 0.56 Published 2006 Journal J. Biol. Chem. Section Abstract Doc Link 16899456 Disease Relevance 0 Pain Relevance 0.15
Moreover, Brn-3a deficiency caused the disappearance of TG neurons which were immunoreactive for VRL-1.
Positive_regulation (immunoreactive) of VRL-1 in neurons associated with trigeminal ganglion
3) Confidence 0.47 Published 2002 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 12225879 Disease Relevance 0.50 Pain Relevance 0.46
TRPV2 is activated by membrane stretch, a property relevant for its sensory role in the gut.
Positive_regulation (activated) of TRPV2 in gut
4) Confidence 0.42 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.67 Pain Relevance 0.30
TRPV2 is activated in vitro by physical stimuli such as heat, osmotic and mechanical stretch [22, 90, 144] and chemical stimulus by 2-aminoethoxydiphenyborate (2-APB) [80].
Positive_regulation (activated) of TRPV2
5) Confidence 0.42 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.51 Pain Relevance 0.27
In arterial myocytes, TRPV2 is activated by stretch, which is an important stimulus in cardiovascular functions [32].
Positive_regulation (activated) of TRPV2 in myocytes
6) Confidence 0.38 Published 2006 Journal Mol Pain Section Body Doc Link PMC1563450 Disease Relevance 0.49 Pain Relevance 0.39
Other members of the family also respond to elevated temperatures, with TRPV2 being activated at a remarkably high heat threshold (for a review, see Jordt et al. 2003).
Positive_regulation (activated) of TRPV2
7) Confidence 0.29 Published 2008 Journal Cell Tissue Res Section Body Doc Link PMC2516536 Disease Relevance 0.19 Pain Relevance 0.40
M, AP18 was unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8 (Figure 2).
Positive_regulation (activation) of TRPV2
8) Confidence 0.28 Published 2007 Journal Mol Pain Section Body Doc Link PMC2222610 Disease Relevance 0.25 Pain Relevance 0.37
Innocuous warm temperatures (27-32oC) activate the thermoTRP TRPV4 (previously coined with several names, including VRL-2, OTRPC4, VR-OAC and TRP12).
Positive_regulation (activate) of VRL-2
9) Confidence 0.28 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.55 Pain Relevance 0.64
These regulatory mechanisms that induce membrane localization of TRPV2 seem to be important regulation mechanisms for TRPV2 activation.


Positive_regulation (activation) of TRPV2
10) Confidence 0.28 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2645548 Disease Relevance 0.42 Pain Relevance 0.28
A high expression level of the VR-1 like protein (VRL-1) was observed in peritoneal macrophages, while the expression of VR-1 was not detected.
Positive_regulation (level) of VRL-1 in peritoneal macrophages
11) Confidence 0.27 Published 2003 Journal Cell. Signal. Section Abstract Doc Link 12531428 Disease Relevance 0.36 Pain Relevance 1.06
TRPV2, a relatively close TRPV1 homolog, in addition to heat (threshold >52°C) [29] is activated by cell swelling and membrane stretch [61], and also by growth factors [62] and ?
Positive_regulation (activated) of TRPV2 associated with pressure and volume under development
12) Confidence 0.27 Published 2008 Journal Mol Pain Section Body Doc Link PMC2386863 Disease Relevance 0.10 Pain Relevance 0.21

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