INT105231

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Context Info
Confidence 0.03
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 6.79
Pain Relevance 1.00

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds (cad) extracellular space (Crp) ligase activity (cad)
cellular amino acid metabolic process (cad)
Anatomy Mention Frequency
coronary artery 2
proximal 1
Crp (Mus musculus)
cad (Danio rerio)
Pain Term Frequency Confidence Heat
Inflammation 23 92.04 High High
Angina 18 80.00 Quite High
imagery 46 76.32 Quite High
ischemia 11 68.80 Quite High
metalloproteinase 2 51.04 Quite High
Pain refractory 4 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
referred pain 1 5.00 Very Low Very Low Very Low
Disease Term Frequency Confidence Heat
Coronary Artery Disease 234 100.00 Very High Very High Very High
Increased Venous Pressure Under Development 10 95.12 Very High Very High Very High
Disease 7 94.52 High High
Myocardial Infarction 18 93.36 High High
INFLAMMATION 23 92.04 High High
Natriuresis 2 88.56 High High
Cardiovascular Disease 22 87.00 High High
Congenital Anomalies 3 81.52 Quite High
Cv General 3 Under Development 6 80.00 Quite High
Stable Angina Pectoris 5 77.12 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent studies have indicated a possible association between C-reactive protein (CRP) and the clinical outcome of coronary artery disease (CAD).
C-reactive protein Binding (association) of CAD in coronary artery associated with coronary artery disease
1) Confidence 0.03 Published 2002 Journal Am. Heart J. Section Abstract Doc Link 12228781 Disease Relevance 0.87 Pain Relevance 0.19
Recent studies have indicated a possible association between C-reactive protein (CRP) and the clinical outcome of coronary artery disease (CAD).
CRP Binding (association) of CAD in coronary artery associated with coronary artery disease
2) Confidence 0.03 Published 2002 Journal Am. Heart J. Section Abstract Doc Link 12228781 Disease Relevance 0.87 Pain Relevance 0.19
In our study we attempted to confirm the reported association of rs2259816 to CRP and CAD in the LURIC Study cohort.


CRP Binding (association) of CAD associated with coronary artery disease
3) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2994837 Disease Relevance 0.53 Pain Relevance 0.12
These findings are in line with Grammer et al. who didn't find an association of polymorphisms in the CRP gene itself and CAD in LURIC [12] and support the view that CRP does not play a causal role in the development of CAD.
CRP gene Binding (association) of CAD associated with coronary artery disease
4) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2994837 Disease Relevance 0.95 Pain Relevance 0.04
These findings are in line with Grammer et al. who didn't find an association of polymorphisms in the CRP gene itself and CAD in LURIC [12] and support the view that CRP does not play a causal role in the development of CAD.
CRP gene Binding (association) of CAD associated with coronary artery disease
5) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2994837 Disease Relevance 0.95 Pain Relevance 0.04
Most of these studies didn't find an association between CRP and CAD [7-13] whereas a few did present some evidence in favor of this idea [14-16].
CRP Binding (association) of CAD associated with coronary artery disease
6) Confidence 0.02 Published 2010 Journal BMC Med Genet Section Body Doc Link PMC2994837 Disease Relevance 0.87 Pain Relevance 0.08
After adjustment of these risk factors by multivariate regression analyses the CRP association with CAD become attenuated but was still statistically significant (p=0.03).
CRP Binding (association) of CAD
7) Confidence 0.02 Published 2004 Journal Anadolu Kardiyol Derg Section Body Doc Link 15355818 Disease Relevance 0.19 Pain Relevance 0
After adjustment of these risk factors by multivariate regression analyses the CRP association with CAD become attenuated but was still statistically significant (p=0.03).
CRP Binding (association) of CAD
8) Confidence 0.02 Published 2004 Journal Anadolu Kardiyol Derg Section Body Doc Link 15355818 Disease Relevance 0.19 Pain Relevance 0
Similarly, two recent prospective studies and a meta-analysis of previous studies have shown, that interleukin 6 (IL-6), a proximal mediator of CRP, are associated with risk of CAD about as strongly and in addition to established risk factors [12].
CRP Binding (associated) of CAD in proximal associated with coronary artery disease
9) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2995735 Disease Relevance 1.36 Pain Relevance 0.34

General Comments

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