INT105247

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Context Info
Confidence 0.67
First Reported 2002
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 12
Total Number 18
Disease Relevance 12.07
Pain Relevance 2.05

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
retina 4
neurons 2
spinal cord 2
muscle 2
GCL 2
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 18 100.00 Very High Very High Very High
COX2 3 100.00 Very High Very High Very High
chemokine 22 99.74 Very High Very High Very High
Spinal cord 6 99.48 Very High Very High Very High
rheumatoid arthritis 1 97.04 Very High Very High Very High
dexamethasone 16 96.08 Very High Very High Very High
Parenteral administration 6 90.24 High High
Pain 14 88.24 High High
Kinase C 2 83.60 Quite High
isoflurane 1 81.44 Quite High
Disease Link Frequency Relevance Heat
Ulcers 31 100.00 Very High Very High Very High
Diabetes Mellitus 187 99.48 Very High Very High Very High
Hypertrophy 10 99.32 Very High Very High Very High
Congenital Anomalies 14 99.24 Very High Very High Very High
Glioma 24 99.00 Very High Very High Very High
Malignant Neoplastic Disease 7 98.68 Very High Very High Very High
Solid Tumor 18 98.06 Very High Very High Very High
Rheumatoid Arthritis 1 97.04 Very High Very High Very High
Relapsing Polychondritis 1 96.04 Very High Very High Very High
Lymphatic System Cancer 1 95.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Studies in vitro suggest that one mechanism for resistance to chemotherapy is the increased expression of vascular endothelial growth factor A (VEGF-A) that is primarily responsible for the vascularization of solid tumors.37,38 Paclitaxel, docetaxel,39 cisplatin,40 carboplatin,41 anthracyclines,42 fluorouracil43 can induce VEGF-A expression.
Positive_regulation (increased) of Gene_expression (expression) of VEGF-A associated with solid tumor
1) Confidence 0.67 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.63 Pain Relevance 0.05
Chemotherapy-induced VEGF-A production is possibly mediated by mitogen-activated protein kinase/extracellular regulated kinase pathway, nuclear factor ?
Spec (possibly) Positive_regulation (mediated) of Gene_expression (production) of VEGF-A
2) Confidence 0.67 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.67 Pain Relevance 0.04
Chemotherapy-induced VEGF-A production is possibly mediated by mitogen-activated protein kinase/extracellular regulated kinase pathway, nuclear factor ?
Positive_regulation (induced) of Gene_expression (production) of VEGF-A
3) Confidence 0.67 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.67 Pain Relevance 0.04
Studies in vitro suggest that one mechanism for resistance to chemotherapy is the increased expression of vascular endothelial growth factor A (VEGF-A) that is primarily responsible for the vascularization of solid tumors.37,38 Paclitaxel, docetaxel,39 cisplatin,40 carboplatin,41 anthracyclines,42 fluorouracil43 can induce VEGF-A expression.
Positive_regulation (induce) of Gene_expression (expression) of VEGF-A associated with solid tumor
4) Confidence 0.67 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.67 Pain Relevance 0.04
We investigated whether the expression of vascular endothelial growth factor (VEGF) is elevated at the onset of hypertrophy when capillary proliferation is minimal, and whether muscle damage as assessed by muscle force deficits, may occur at the onset of hypertrophy.
Spec (whether) Positive_regulation (elevated) of Gene_expression (expression) of vascular endothelial growth factor in muscle associated with hypertrophy
5) Confidence 0.62 Published 2003 Journal Jpn. J. Physiol. Section Abstract Doc Link 14529579 Disease Relevance 0.45 Pain Relevance 0.12
Chemotherapy-induced VEGF-A production is possibly mediated by mitogen-activated protein kinase/extracellular regulated kinase pathway, nuclear factor ?
Spec (possibly) Positive_regulation (mediated) of Gene_expression (production) of VEGF-A
6) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.67 Pain Relevance 0.04
Studies in vitro suggest that one mechanism for resistance to chemotherapy is the increased expression of vascular endothelial growth factor A (VEGF-A) that is primarily responsible for the vascularization of solid tumors.37,38 Paclitaxel, docetaxel,39 cisplatin,40 carboplatin,41 anthracyclines,42 fluorouracil43 can induce VEGF-A expression.
Positive_regulation (increased) of Gene_expression (expression) of VEGF-A associated with solid tumor
7) Confidence 0.49 Published 2009 Journal OncoTargets and therapy Section Body Doc Link PMC2886338 Disease Relevance 0.63 Pain Relevance 0.05
Increased expression of cyclo-oxygenase 2 and vascular endothelial growth factor in lesioned spinal cord by transplanted olfactory ensheathing cells.
Positive_regulation (Increased) of Gene_expression (expression) of vascular endothelial growth factor in spinal cord associated with cox2 and spinal cord
8) Confidence 0.36 Published 2004 Journal J. Neurotrauma Section Title Doc Link 15319002 Disease Relevance 0.18 Pain Relevance 0.34
Contrasting with most adult CNS neurons, hypothalamic magnocellular neurons were found to express vascular endothelial growth factor (VEGF), a potent angiogenic factor whose production was increased by osmotic stimulus.
Positive_regulation (increased) of Gene_expression (production) of vascular endothelial growth factor in neurons
9) Confidence 0.33 Published 2005 Journal BMC Neurosci Section Abstract Doc Link PMC1079868 Disease Relevance 0.06 Pain Relevance 0.05
The number of cells in the retinal ganglion cell layer (GCL), retinal function (using electroretinography [ERG]), and retinal levels of inducible nitric oxide synthase (iNOS), cyclooxygenase2 (COX2), and vascular endothelial growth factor (VEGF) were measured at four months of diabetes.
Positive_regulation (inducible) of Gene_expression (nitric oxide synthase) of vascular endothelial growth factor in GCL
10) Confidence 0.32 Published 2010 Journal Mol. Vis. Section Body Doc Link 20806092 Disease Relevance 0.34 Pain Relevance 0
It has known to cause choroidal hypoperfusion and production of vascular endothelial growth factor.
Positive_regulation (cause) of Gene_expression (production) of vascular endothelial growth factor
11) Confidence 0.26 Published 2007 Journal Indian Journal of Ophthalmology Section Abstract Doc Link PMC2635983 Disease Relevance 0.57 Pain Relevance 0
These findings were associated with enhanced expression of p27Kip1 and with the classic abnormalities of diabetic retina—i.e., fibronectin accumulation, increased expression of retinal vascular endothelial growth factor (VEGF), and blood-retinal barrier breakdown.


Positive_regulation (accumulation) of Gene_expression (expression) of vascular endothelial growth factor in retina associated with diabetes mellitus and congenital anomalies
12) Confidence 0.24 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.74 Pain Relevance 0.07
These findings were associated with enhanced expression of p27Kip1 and with the classic abnormalities of diabetic retina—i.e., fibronectin accumulation, increased expression of retinal vascular endothelial growth factor (VEGF), and blood-retinal barrier breakdown.


Positive_regulation (increased) of Gene_expression (expression) of vascular endothelial growth factor in retina associated with diabetes mellitus and congenital anomalies
13) Confidence 0.24 Published 2008 Journal Molecular Vision Section Body Doc Link PMC2538494 Disease Relevance 0.74 Pain Relevance 0.07
It has been also recognized as an angiogenic chemokine through the induction of VEGF (vascular endothelial growth factor) -A gene expression [21].
Positive_regulation (induction) of Gene_expression (expression) of vascular endothelial growth factor associated with chemokine
14) Confidence 0.17 Published 2005 Journal BMC Immunol Section Body Doc Link PMC1190175 Disease Relevance 0.48 Pain Relevance 0.50
Angiogenesis was also significantly stimulated together with the induction of vascular endothelial growth factor (VEGF) expression.
Positive_regulation (induction) of Gene_expression (expression) of vascular endothelial growth factor
15) Confidence 0.17 Published 2007 Journal Eur. J. Pharmacol. Section Abstract Doc Link 17395175 Disease Relevance 1.19 Pain Relevance 0.07
In gliomas, the best characterized pro-angiogenic factor is vascular endothelial growth factor (VEGF), whose overexpression is correlated with increasingly malignant phenotypes [18].
Positive_regulation (overexpression) of Gene_expression (overexpression) of vascular endothelial growth factor associated with malignant neoplastic disease and glioma
16) Confidence 0.15 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2661078 Disease Relevance 1.41 Pain Relevance 0.04
We conclude that H. pylori antagonizes, in part, aspirin-induced delay of ulcer healing due to suppression of acid secretion, the enhancement in prostaglandin E(2) possibly derived from cyclooxygenase-2 and the overexpression of transforming growth factor alpha and vascular endothelial growth factor in the ulcer area.
Positive_regulation (aspirin-induced) of Gene_expression (overexpression) of vascular endothelial growth factor associated with aspirin and ulcers
17) Confidence 0.07 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12231391 Disease Relevance 1.01 Pain Relevance 0.28
We conclude that H. pylori antagonizes, in part, aspirin-induced delay of ulcer healing due to suppression of acid secretion, the enhancement in prostaglandin E(2) possibly derived from cyclooxygenase-2 and the overexpression of transforming growth factor alpha and vascular endothelial growth factor in the ulcer area.
Positive_regulation (overexpression) of Gene_expression (overexpression) of vascular endothelial growth factor associated with aspirin and ulcers
18) Confidence 0.07 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12231391 Disease Relevance 0.95 Pain Relevance 0.26

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