INT105248

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Context Info
Confidence 0.47
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 6.19
Pain Relevance 1.61

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell proliferation (Vegfa) extracellular space (Vegfa) growth (Vegfa)
extracellular region (Vegfa) cytoplasm (Vegfa)
Anatomy Link Frequency
endothelial cell 2
myocardium 1
Vegfa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
aspirin 16 99.98 Very High Very High Very High
cINOD 6 98.84 Very High Very High Very High
cytokine 18 94.84 High High
Hippocampus 1 92.96 High High
Inflammation 33 86.04 High High
ischemia 6 85.28 High High
depression 2 78.72 Quite High
dopamine receptor 1 74.56 Quite High
Enkephalin 1 71.84 Quite High
Dynorphin 1 70.88 Quite High
Disease Link Frequency Relevance Heat
Renal Disease 2 99.84 Very High Very High Very High
Ulcers 26 99.32 Very High Very High Very High
Stress 24 99.20 Very High Very High Very High
Adhesions 7 98.60 Very High Very High Very High
Diabetes Mellitus 164 97.68 Very High Very High Very High
Shock 3 95.84 Very High Very High Very High
Necrosis 2 93.76 High High
Cancer 5 93.40 High High
Toxicity 13 92.36 High High
Infection 1 89.00 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Moreover, in the CA3 we found downregulation of vascular endothelial growth factor (VEGF) mRNA in the CMS sensitive group.
Negative_regulation (downregulation) of vascular endothelial growth factor associated with stress
1) Confidence 0.47 Published 2008 Journal Brain Res. Section Abstract Doc Link 18234161 Disease Relevance 1.17 Pain Relevance 0.30
The prolongation of the healing in diabetic animals was associated with an increase in gastric mucosal expression and release of TNFalpha, interleukin-1 beta (IL-1 beta), suppression of the vascular endothelial growth factor (VEGF), platelet endothelial cell adhesion molecule-1 (PECAM-1) and the mucosal overexpression of heat shock protein 70 (HSP 70).
Negative_regulation (suppression) of vascular endothelial growth factor in endothelial cell associated with diabetes mellitus, shock and adhesions
2) Confidence 0.33 Published 2003 Journal Eur. J. Pharmacol. Section Abstract Doc Link 14642793 Disease Relevance 1.49 Pain Relevance 0.10
The reduction of growth factors such as transforming growth factor-alpha (TGF)-alpha and vascular endothelial cell growth factor (VEGF) by aspirin was determined by immunohistochemistry method.
Negative_regulation (reduction) of vascular endothelial cell growth factor in endothelial cell associated with aspirin
3) Confidence 0.31 Published 2008 Journal Int. Immunopharmacol. Section Abstract Doc Link 18773975 Disease Relevance 0.61 Pain Relevance 0.61
VEGFA reproducibly decreased at 1 month (Figure 3).
Negative_regulation (decreased) of VEGFA
4) Confidence 0.27 Published 2008 Journal BMC Med Genomics Section Body Doc Link PMC2442612 Disease Relevance 0.24 Pain Relevance 0.09
Several studies have reported the possible role of decreased vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang-1) in the pathogenesis of diabetes-mediated impairment of angiogenesis in the myocardium (5–7).
Spec (possible) Negative_regulation (decreased) of vascular endothelial growth factor in myocardium associated with diabetes mellitus
5) Confidence 0.13 Published 2010 Journal Diabetes Section Body Doc Link PMC2797944 Disease Relevance 1.24 Pain Relevance 0.14
Aspirin reduced significantly the transforming growth factor alpha- and vascular endothelial growth factor mRNAs, but these effects were significantly attenuated by H. pylori.
Negative_regulation (reduced) of vascular endothelial growth factor associated with aspirin
6) Confidence 0.08 Published 2002 Journal Eur. J. Pharmacol. Section Abstract Doc Link 12231391 Disease Relevance 1.08 Pain Relevance 0.30
A breakdown of BBB permeability and other vascular beds has been observed following intravenous injection of large amounts of cationic proteins, but has not been seen when moderate amounts of these substances were administered (1).
Negative_regulation (breakdown) of permeability
7) Confidence 0.01 Published 2008 Journal AAPS J Section Body Doc Link PMC2761699 Disease Relevance 0.35 Pain Relevance 0
The converse substitution in P2X2 receptors (P2X2[D349N]) does not reduce calcium permeability (13).
Neg (not) Negative_regulation (reduce) of permeability
8) Confidence 0.00 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2397467 Disease Relevance 0 Pain Relevance 0.06

General Comments

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