INT105283

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Context Info
Confidence 0.68
First Reported 2002
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 5
Disease Relevance 1.86
Pain Relevance 1.01

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1)
cytoplasm (Tjp1)
Anatomy Link Frequency
ileum 2
brain 2
bowel 2
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 11 97.88 Very High Very High Very High
ischemia 56 96.92 Very High Very High Very High
IPN 8 83.12 Quite High
Central nervous system 2 53.76 Quite High
Pain 6 25.00 Low Low
cytokine 4 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
imagery 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Inflammatory Bowel Disease 2 97.88 Very High Very High Very High
Reperfusion Injury 42 97.68 Very High Very High Very High
Cv Unclassified Under Development 48 96.92 Very High Very High Very High
Inflammatory Pain 8 83.12 Quite High
INFLAMMATION 2 72.68 Quite High
Injury 2 57.44 Quite High
Necrosis 2 39.52 Quite Low
Cv General 4 Under Development 8 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 4 5.00 Very Low Very Low Very Low
Enteropathy 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ZO-1 expression was significantly increased at 1, 3, and 6 h and returned to control expression levels by 12 h.
Positive_regulation (increased) of Gene_expression (expression) of ZO-1
1) Confidence 0.68 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12234806 Disease Relevance 0.30 Pain Relevance 0.29
ZO-1 expression was significantly increased at 1, 3, and 6 h and returned to control expression levels by 12 h.
Positive_regulation (increased) of Gene_expression (expression) of ZO-1
2) Confidence 0.49 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12234806 Disease Relevance 0.30 Pain Relevance 0.29
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Positive_regulation (increased) of Gene_expression (expression) of ZO-1 in brain
3) Confidence 0.25 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14
Immunohistochemistry using control sections of rat ileum demonstrated the expression of claudin-1, claudin-2, claudin-3, claudin-4, claudin-5, ZO-1, and occludin.
Positive_regulation (demonstrated) of Gene_expression (expression) of ZO-1 in ileum
4) Confidence 0.19 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.68 Pain Relevance 0.15
Furthermore, it would be of value to study what changes in tight-junction protein expression occur in humans, such as patients with ischemic and inflammatory bowel disease, with the goal of understanding the pathogenesis more clearly.



Positive_regulation (changes) of Gene_expression (expression) of tight-junction protein in bowel associated with inflammation
5) Confidence 0.17 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.44 Pain Relevance 0.14

General Comments

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