INT105284

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Context Info
Confidence 0.78
First Reported 2002
Last Reported 2010
Negated 0
Speculated 4
Reported most in Body
Documents 39
Total Number 44
Disease Relevance 14.98
Pain Relevance 5.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
brain 5
ileum 3
epithelium 3
cecum 2
small intestine 2
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 704 99.38 Very High Very High Very High
ischemia 400 99.38 Very High Very High Very High
Neuropathic pain 1 94.44 High High
Central nervous system 10 91.36 High High
IPN 12 91.20 High High
dexamethasone 2 91.00 High High
Inflammation 157 90.80 High High
metalloproteinase 4 89.24 High High
alcohol 8 85.08 High High
cytokine 76 83.84 Quite High
Disease Link Frequency Relevance Heat
Adhesions 44 100.00 Very High Very High Very High
Pancreatitis 160 99.82 Very High Very High Very High
Reperfusion Injury 275 99.76 Very High Very High Very High
Cv Unclassified Under Development 338 99.38 Very High Very High Very High
Sepsis 97 98.36 Very High Very High Very High
Sprains And Strains 203 98.14 Very High Very High Very High
Cv General 4 Under Development 60 97.56 Very High Very High Very High
Diabetes Mellitus 326 97.44 Very High Very High Very High
Obesity 352 96.48 Very High Very High Very High
Apoptosis 60 96.36 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lungs were examined histochemically and number of neutrophile granulocytes, alveolar septal thickness, air/tissue ratio, number of alveoli per field, number of type II pneumocytes per alveolus, and occludin 1 expression were measured.
Gene_expression (expression) of occludin 1 in Lungs
1) Confidence 0.78 Published 2004 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 15625787 Disease Relevance 0.22 Pain Relevance 0.12
It analyzes the expressions of occludin, ZO-1, and connexin 43 by immunoconfocal microscopy.
Spec (analyzes) Gene_expression (expressions) of occludin
2) Confidence 0.75 Published 2005 Journal Int. J. Neurosci. Section Abstract Doc Link 16162451 Disease Relevance 0.36 Pain Relevance 0.13
Furthermore, changes in BBB function are correlated with altered tight junctional protein expression of occludin and ZO-1.
Gene_expression (expression) of occludin
3) Confidence 0.64 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12234806 Disease Relevance 0.22 Pain Relevance 0.24
A lower occludin 1 expression was observed in animals irradiated with the doses of 5 20 Gy, indicating an effect on vascular permeability.
Gene_expression (expression) of occludin 1
4) Confidence 0.53 Published 2004 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 15625787 Disease Relevance 0.31 Pain Relevance 0.19
Total occludin expression was significantly reduced at 1, 3, 6, 12, and 48 h.
Gene_expression (expression) of occludin
5) Confidence 0.43 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12234806 Disease Relevance 0.30 Pain Relevance 0.29
To explore the mechanisms underlying the high fat-induced increase in intestinal permeability, we evaluated the expression of TJ proteins, occludin, claudin-1, claudin-3, and JAM-1, and their association with the actin cytoskeleton in the small intestine, cecum and colon of rats.
Gene_expression (expression) of occludin in small intestine
6) Confidence 0.36 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0.18 Pain Relevance 0
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Gene_expression (expression) of occludin in brain
7) Confidence 0.35 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14
As described above, the OLETF rats fed the standard diet did not exhibit any increase in intestinal permeability in comparison to the counter strain LETO rats fed the same diet, although 2 obese mouse models, the leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) strains, reportedly showed increases in intestinal permeability with a concomitant reduction in the expression of TJ proteins, ZO-1 and occludin [5].
Gene_expression (expression) of occludin associated with obesity and sprains and strains
8) Confidence 0.31 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 1.22 Pain Relevance 0.27
Feeding the high fat diet clearly decreased the expression of some TJ proteins and their cytoskeletal association in the small intestines of LETO and OLETF rats, although we did not find any statistical differences in occludin expression (P = 0.09, 2-way ANOVA) in the small intestine.
Gene_expression (expression) of occludin in small intestines
9) Confidence 0.31 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0.06 Pain Relevance 0
Membranes were blotted for occludin, claudin-1, claudin-3, JAM-1, and ?
Gene_expression (blotted) of occludin
10) Confidence 0.31 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0 Pain Relevance 0
Others have shown that reductions in claudin 4 and occludin expression can lead to increases in permeability, suggesting that the reductions in the tight junction proteins observed in our studies may be responsible for the differences in barrier function between 2CLP and sham monolayers [35], [36], [37].


Gene_expression (expression) of occludin
11) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.14 Pain Relevance 0
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Gene_expression (i.e.) of occludin in brain
12) Confidence 0.30 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14
Claudin-1, claudin-3, claudin-5, ZO-1, and occludin were expressed in linear fashion along the whole surface of the epithelial cells from the crypts to the villi with a typical reticular pattern (Fig. 3A1, C1, E1–G1).
Gene_expression (expressed) of occludin in epithelial cells
13) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.65 Pain Relevance 0.15
Claudin-1, claudin-2, claudin-3, claudin-5, ZO-1, and occludin expression was observed in the recovering epithelium, but the reticular pattern was partly disrupted and irregular at the apical surfaces.
Gene_expression (expression) of occludin in epithelium
14) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.28 Pain Relevance 0.07
The reticular pattern of the tight junction protein ZO-1, occludin and claudin-1, -3, and -5 expression observed at 24 hr post-reperfusion may reflect the functional recovery of tight junctions.
Gene_expression (expression) of occludin
15) Confidence 0.29 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.36 Pain Relevance 0.11
Here we show that the protein levels of occludin and ZO-1 are not altered, but instead their interaction is considerably reduced in the sonicated brain areas, suggesting that the decrease in immunogold signals may be the consequence of the redistribution of tight junction proteins.
Gene_expression (levels) of occludin in brain
16) Confidence 0.28 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Western blot analysis with brain tissue homogenates show that the protein levels of the tight junction proteins ZO-1 and occludin in the ultrasound treated region is not changed compared to non-treated regions (Figure 3A).
Gene_expression (levels) of occludin in brain
17) Confidence 0.28 Published 2010 Journal BMC Neurol Section Body Doc Link PMC3020671 Disease Relevance 0 Pain Relevance 0
Feeding the high fat diet increased intestinal permeability in both the OLETF and LETO rats, and the increases correlated with decreases in TJ proteins (claudin-1, claudin-3, occludin and junctional adhesion molecule-1) expression in the small, but not in the large intestine (cecum or colon).
Gene_expression (expression) of occludin in large intestine associated with adhesions
18) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2848226 Disease Relevance 0.71 Pain Relevance 0.23
Occludin expression in the cells incubated with 10 and 20% bile juice were lower and higher than the control value, respectively, whereas the expression of JAM-1 and claudin-1 in cells incubated with 10 and 20% bile juice and claudin-3 in those incubated with 20% bile juice were all lower than the control value.
Gene_expression (expression) of Occludin in bile associated with bile
19) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0 Pain Relevance 0.35
Bile juice treatment decreased the expression of TJ proteins, except for occludin, in a dose-dependent manner (Fig. 9A).
Gene_expression (expression) of occludin in Bile associated with bile
20) Confidence 0.28 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0 Pain Relevance 0.34

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