INT105285

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Context Info
Confidence 0.26
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 6
Total Number 6
Disease Relevance 2.73
Pain Relevance 1.08

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Golgi apparatus (Tjp1) plasma membrane (Tjp1) nucleus (Tjp1)
cytoplasm (Tjp1)
Anatomy Link Frequency
intestine 4
bowel 2
Tjp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
ischemia 113 99.68 Very High Very High Very High
Inflammation 12 97.88 Very High Very High Very High
IPN 3 92.52 High High
Central nervous system 1 92.08 High High
cytokine 14 86.44 High High
Pain 2 25.00 Low Low
anesthesia 5 5.00 Very Low Very Low Very Low
imagery 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 3 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cv Unclassified Under Development 97 99.68 Very High Very High Very High
Reperfusion Injury 84 99.32 Very High Very High Very High
Cv General 4 Under Development 16 98.86 Very High Very High Very High
Inflammatory Bowel Disease 4 97.88 Very High Very High Very High
Inflammatory Pain 3 92.52 High High
Death 3 77.88 Quite High
Injury 8 62.92 Quite High
INFLAMMATION 10 54.36 Quite High
Necrosis 4 45.00 Quite Low
Multiple Organ Failure 5 12.80 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Furthermore, changes in BBB function are correlated with altered tight junctional protein expression of occludin and ZO-1.
Regulation (altered) of Gene_expression (expression) of ZO-1
1) Confidence 0.26 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12234806 Disease Relevance 0.22 Pain Relevance 0.24
Changes in tight-junction protein expression during ischemia-reperfusion injury
Regulation (Changes) of Gene_expression (expression) of tight-junction protein associated with reperfusion injury and ischemia
2) Confidence 0.21 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.61 Pain Relevance 0.14
Claudin 4, claudin 18, and occludin were all significantly reduced in 2CLP monolayers compared to sham, while no significant differences in the expression of claudin 3, 5, 7, 8, ZO-1, and JAM-A were observed.
Neg (no) Regulation (differences) of Gene_expression (expression) of ZO-1
3) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.15 Pain Relevance 0
Although it is quite likely that the functions of tight-junction proteins are dramatically changed during the recovery of intestinal epithelium from intestinal ischemia-reperfusion injury, only a few reports are available on changes of tight-junction protein expression, such as the one on occludin and ZO-1 expression in porcine intestine [11].
Regulation (changes) of Gene_expression (expression) of ZO-1 in intestine associated with reperfusion injury, cv general 4 under development and ischemia
4) Confidence 0.10 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.67 Pain Relevance 0.29
Although it is quite likely that the functions of tight-junction proteins are dramatically changed during the recovery of intestinal epithelium from intestinal ischemia-reperfusion injury, only a few reports are available on changes of tight-junction protein expression, such as the one on occludin and ZO-1 expression in porcine intestine [11].
Regulation (changes) of Gene_expression (expression) of tight-junction protein in intestine associated with reperfusion injury, cv general 4 under development and ischemia
5) Confidence 0.09 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.65 Pain Relevance 0.28
Furthermore, it would be of value to study what changes in tight-junction protein expression occur in humans, such as patients with ischemic and inflammatory bowel disease, with the goal of understanding the pathogenesis more clearly.



Regulation (changes) of Gene_expression (expression) of tight-junction protein in bowel associated with inflammation
6) Confidence 0.09 Published 2006 Journal Acta Histochemica et Cytochemica Section Body Doc Link PMC1828083 Disease Relevance 0.44 Pain Relevance 0.14

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