INT105286

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Context Info
Confidence 0.31
First Reported 2002
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 2.52
Pain Relevance 1.35

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Ocln) plasma membrane (Ocln) cytoplasm (Ocln)
Anatomy Link Frequency
brain 2
Bile 2
large intestine 2
Ocln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Bile 192 99.66 Very High Very High Very High
IPN 5 92.72 High High
Inflammation 38 84.76 Quite High
Cholecystokinin 6 76.72 Quite High
tolerance 15 67.68 Quite High
anesthesia 8 66.76 Quite High
Central nervous system 1 63.36 Quite High
cytokine 12 59.40 Quite High
ischemia 5 44.64 Quite Low
Pain 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Adhesions 12 100.00 Very High Very High Very High
Sprains And Strains 51 98.48 Very High Very High Very High
Obesity 96 96.70 Very High Very High Very High
Inflammatory Pain 5 92.72 High High
Hyperphagia 3 88.88 High High
Metabolic Disorder 27 84.96 Quite High
INFLAMMATION 38 84.76 Quite High
Impaired Glucose Tolerance 24 83.40 Quite High
Targeted Disruption 5 74.56 Quite High
Death 3 73.60 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Total occludin expression was significantly reduced at 1, 3, 6, 12, and 48 h.
Negative_regulation (reduced) of Gene_expression (expression) of occludin
1) Confidence 0.31 Published 2002 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 12234806 Disease Relevance 0.30 Pain Relevance 0.30
Bile juice treatment decreased the expression of TJ proteins, except for occludin, in a dose-dependent manner (Fig. 9A).
Neg (except) Negative_regulation (decreased) of Gene_expression (expression) of occludin in Bile associated with bile
2) Confidence 0.20 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 0 Pain Relevance 0.34
Feeding the high fat diet increased intestinal permeability in both the OLETF and LETO rats, and the increases correlated with decreases in TJ proteins (claudin-1, claudin-3, occludin and junctional adhesion molecule-1) expression in the small, but not in the large intestine (cecum or colon).
Negative_regulation (decreases) of Gene_expression (expression) of occludin in large intestine associated with adhesions
3) Confidence 0.20 Published 2010 Journal Nutr Metab (Lond) Section Abstract Doc Link PMC2848226 Disease Relevance 0.72 Pain Relevance 0.23
Pharmacological inhibition of ALK5 with the selective inhibitor SB431542 further enhanced brain uptake of (14)C-sucrose, increased TJ protein expression (i.e., claudin-3, claudin-5, occludin, ZO-1), and decreased nuclear expression of TGF-beta/ALK5 signaling molecules (i.e., Smad2, Smad3), which suggests a role for TGF-beta/ALK5 signaling in the regulation of BBB integrity.
Negative_regulation (inhibition) of Gene_expression (expression) of occludin in brain
4) Confidence 0.19 Published 2009 Journal J. Cereb. Blood Flow Metab. Section Abstract Doc Link 19319146 Disease Relevance 0.14 Pain Relevance 0.14
As described above, the OLETF rats fed the standard diet did not exhibit any increase in intestinal permeability in comparison to the counter strain LETO rats fed the same diet, although 2 obese mouse models, the leptin-deficient (ob/ob) and leptin receptor-deficient (db/db) strains, reportedly showed increases in intestinal permeability with a concomitant reduction in the expression of TJ proteins, ZO-1 and occludin [5].
Negative_regulation (reduction) of Gene_expression (expression) of occludin associated with obesity and sprains and strains
5) Confidence 0.17 Published 2010 Journal Nutr Metab (Lond) Section Body Doc Link PMC2848226 Disease Relevance 1.22 Pain Relevance 0.27
Others have shown that reductions in claudin 4 and occludin expression can lead to increases in permeability, suggesting that the reductions in the tight junction proteins observed in our studies may be responsible for the differences in barrier function between 2CLP and sham monolayers [35], [36], [37].


Negative_regulation (reductions) of Gene_expression (expression) of occludin
6) Confidence 0.17 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2892473 Disease Relevance 0.14 Pain Relevance 0
Western blot analysis of VEGF, PEDF, occludin, and p42/p44 MAP kinase
Negative_regulation (blot) of Gene_expression (analysis) of occludin
7) Confidence 0.12 Published 2007 Journal Molecular Vision Section Body Doc Link PMC2533034 Disease Relevance 0 Pain Relevance 0.07

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