INT105304

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Context Info
Confidence 0.28
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 11
Total Number 12
Disease Relevance 11.07
Pain Relevance 9.53

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
DRG 6
neurons 4
spinal cord 2
Purkinje cells 2
hippocampus 2
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 43 100.00 Very High Very High Very High
adenocard 32 100.00 Very High Very High Very High
Hippocampus 26 100.00 Very High Very High Very High
agonist 18 100.00 Very High Very High Very High
dorsal root ganglion 8 100.00 Very High Very High Very High
central sensitization 8 99.68 Very High Very High Very High
Spinal cord 17 99.36 Very High Very High Very High
Lasting pain 7 99.36 Very High Very High Very High
allodynia 12 99.32 Very High Very High Very High
Eae 14 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 20 100.00 Very High Very High Very High
Convulsion 6 100.00 Very High Very High Very High
Muscle Weakness 2 99.68 Very High Very High Very High
Pain 27 99.36 Very High Very High Very High
Neuropathic Pain 34 99.32 Very High Very High Very High
Nervous System Injury 5 99.24 Very High Very High Very High
Injury 27 99.20 Very High Very High Very High
Nociception 30 98.92 Very High Very High Very High
Apoptosis 8 98.76 Very High Very High Very High
INFLAMMATION 19 97.82 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
P2X2 and P2X4 receptor expression in the hippocampus of seizure-prone gerbils was significantly reduced compared with that of normal gerbils [139].
Negative_regulation (reduced) of Gene_expression (expression) of P2X2 in hippocampus associated with convulsion and hippocampus
1) Confidence 0.28 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.87 Pain Relevance 0.48
P2X(3) receptor antagonist A-317491 reduced P2X agonist activated currents and P2X(3) mRNA expression.
Negative_regulation (reduced) of Gene_expression (expression) of P2X associated with antagonist and agonist
2) Confidence 0.22 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 1.10 Pain Relevance 0.75
The results revealed that the myocardial ischemia induced the upregulation of P2X(3) receptor in function and morphous and P2X(3) receptor antagonist A-317491 inhibited P2X agonist activated currents and P2X(3) mRNA expression.
Negative_regulation (inhibited) of Gene_expression (expression) of P2X associated with coronary artery disease, antagonist, ischemia and agonist
3) Confidence 0.22 Published 2008 Journal Brain Res. Bull. Section Abstract Doc Link 18158099 Disease Relevance 0.95 Pain Relevance 0.62
These behavioral effects were significantly correlated with a decrease in P2X(3) receptor protein expression in the dorsal root ganglia (DRG).
Negative_regulation (decrease) of Gene_expression (expression) of P2X in DRG
4) Confidence 0.22 Published 2002 Journal Pain Section Abstract Doc Link 12237180 Disease Relevance 1.15 Pain Relevance 0.97
Overall, the present data demonstrate that activation of P2X(3) receptors contribute to the expression of chronic inflammatory and neuropathic pain states and that relief form these forms of chronic pain might be achieved by selective blockade of P2X(3 )receptor expression or activation.
Negative_regulation (blockade) of Gene_expression (expression) of P2X associated with inflammation, lasting pain and neuropathic pain
5) Confidence 0.22 Published 2002 Journal Pain Section Abstract Doc Link 12237180 Disease Relevance 0.95 Pain Relevance 0.83
In contrast, a decrease in P2X(3) receptor protein expression in the DRG did not affect nociceptive behavior in the carrageenan model of acute thermal hyperalgesia.
Negative_regulation (decrease) of Gene_expression (expression) of P2X in DRG associated with nociception and thermal hyperalgesia
6) Confidence 0.22 Published 2002 Journal Pain Section Abstract Doc Link 12237180 Disease Relevance 1.16 Pain Relevance 1.00
P2X receptor expression was downregulated in Purkinje cells and deep cerebellar nuclei at P21 and P66 rat embryonic stages, with the exception of P2X5 receptors whose immunoreactivity in granular cells was increased [65].
Negative_regulation (downregulated) of Gene_expression (expression) of P2X in Purkinje cells
7) Confidence 0.20 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.35 Pain Relevance 0.15
We also found that the expression level of P2X(4) was increased strikingly in spinal cord microgila after nerve injury and that pharmacological blockade or inhibition of the expression of P2X(4) reversed the allodynia.
Negative_regulation (inhibition) of Gene_expression (expression) of P2X in spinal cord associated with nervous system injury, allodynia and spinal cord
8) Confidence 0.06 Published 2004 Journal J. Pharmacol. Sci. Section Abstract Doc Link 14978347 Disease Relevance 0.88 Pain Relevance 1.04
In CCI rats treated with SF, the up-regulated expression of P2X(3) receptor in DRG neurons was reduced.
Negative_regulation (reduced) of Gene_expression (expression) of P2X in neurons associated with dorsal root ganglion and eae
9) Confidence 0.05 Published 2010 Journal Brain Res. Section Abstract Doc Link 19968976 Disease Relevance 1.64 Pain Relevance 1.26
Therefore, prenatal exposure to glucocorticoids leads to a transient inhibition of P2X(3) expression in the DRG and SC, suggesting a potential involvement of P2X(3) receptors in the unique profile of pain perception in neonates.
Negative_regulation (inhibition) of Gene_expression (expression) of P2X in DRG associated with pain and spinal cord
10) Confidence 0.05 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18541457 Disease Relevance 0.15 Pain Relevance 0.50
Superfusion of the selective P2X1, P2X3 and P2X(2/3) receptor antagonist 2',3'-O-(2,4,6-trinitrophenyl) adenosine 5'-triphosphate (6-638 microM) partially blocked the Vc central sensitization.
Negative_regulation (blocked) of Gene_expression (Superfusion) of P2X associated with adenocard, central sensitization and antagonist
11) Confidence 0.04 Published 2005 Journal J. Neurophysiol. Section Abstract Doc Link 15901761 Disease Relevance 0.24 Pain Relevance 0.67
The expression of P2X(3) receptor in DRG neurons was increased after CCI.
Negative_regulation (receptor) of Gene_expression (expression) of P2X in neurons associated with dorsal root ganglion and eae
12) Confidence 0.04 Published 2010 Journal Brain Res. Section Abstract Doc Link 19968976 Disease Relevance 1.64 Pain Relevance 1.25

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