INT105306

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Context Info
Confidence 0.21
First Reported 2002
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 7
Total Number 9
Disease Relevance 6.92
Pain Relevance 5.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (P2rx2)
Anatomy Link Frequency
neurons 5
dorsal root ganglia 5
hippocampus 4
P2rx2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 26 100.00 Very High Very High Very High
vanilloid receptor subtype 1 6 100.00 Very High Very High Very High
substance P 4 100.00 Very High Very High Very High
Calcitonin gene-related peptide 4 100.00 Very High Very High Very High
Spinal cord 18 99.76 Very High Very High Very High
Cancer pain 4 99.52 Very High Very High Very High
Eae 11 99.40 Very High Very High Very High
dorsal root ganglion 5 99.36 Very High Very High Very High
ischemia 18 98.88 Very High Very High Very High
Pain 17 97.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer Pain 4 99.52 Very High Very High Very High
Injury 19 99.40 Very High Very High Very High
Ganglion Cysts 5 99.36 Very High Very High Very High
Mouth Cancer 4 99.32 Very High Very High Very High
Colitis 6 99.24 Very High Very High Very High
Cv Unclassified Under Development 16 98.88 Very High Very High Very High
Pain 14 97.92 Very High Very High Very High
Stress 4 97.16 Very High Very High Very High
Convulsion 6 97.00 Very High Very High Very High
Hyperalgesia 9 96.68 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
For example, P2X2 and P2X4 receptor expression in neurons and microglia, respectively, in the hippocampus of gerbils was upregulated following transient global ischemia [161].
Regulation (upregulated) of Gene_expression (expression) of P2X2 in hippocampus associated with ischemia and hippocampus
1) Confidence 0.21 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 1.33 Pain Relevance 0.37
The effect of formalin on the expression of P2X(3) receptors in dorsal root ganglia (DRG) was characterized using molecular and immunological approaches and the patch-clamp technique. 2.
Regulation (effect) of Gene_expression (expression) of P2X in dorsal root ganglia
2) Confidence 0.17 Published 2009 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 19473342 Disease Relevance 0.27 Pain Relevance 0.18
GABAA receptors mediated modulation of expression of both P2X2 and P2X4 receptors, which may play an important role in the regulation of seizure activity in the gerbil hippocampus [139].
Regulation (modulation) of Gene_expression (expression) of P2X2 in hippocampus associated with convulsion and hippocampus
3) Confidence 0.13 Published 2007 Journal Purinergic Signal Section Body Doc Link PMC2072925 Disease Relevance 0.79 Pain Relevance 0.45
Estrogen altered visceromotor reflex and P2X(3) mRNA expression in a rat model of colitis.
Regulation (altered) of Gene_expression (expression) of P2X associated with colitis
4) Confidence 0.12 Published 2009 Journal Steroids Section Title Doc Link 19628002 Disease Relevance 0.57 Pain Relevance 0.12
In contrast, there was no change in expression of P2X(3) mRNA over 4 weeks after ligation, or in the percentage of P2X(3)-ir neurons observed 3 days after surgery.
Neg (no) Regulation (change) of Gene_expression (expression) of P2X in neurons
5) Confidence 0.09 Published 2002 Journal Pain Section Abstract Doc Link 12237189 Disease Relevance 0.42 Pain Relevance 0.84
In CCI rats treated with SF, the up-regulated expression of P2X(3) receptor in DRG neurons was reduced.
Regulation (regulated) of Gene_expression (expression) of P2X in neurons associated with dorsal root ganglion and eae
6) Confidence 0.04 Published 2010 Journal Brain Res. Section Abstract Doc Link 19968976 Disease Relevance 1.63 Pain Relevance 1.25
We examined the importance of membrane cholesterol for the function and expression of TRPV1 (vanilloid receptor subtype 1) and P2X(3) in adult rat dorsal root ganglion (DRG) neurons.
Spec (examined) Regulation (importance) of in dorsal root ganglion Gene_expression (expression) of P2X in neurons associated with ganglion cysts, dorsal root ganglion and vanilloid receptor subtype 1
7) Confidence 0.03 Published 2006 Journal Eur. J. Neurosci. Section Abstract Doc Link 16800863 Disease Relevance 0.10 Pain Relevance 0.31
The aim of this study is to determine whether prenatal exposure to glucocorticoids alters the expression of P2X(3) and TRPV(1) in the dorsal root ganglia (DRG) and spinal cord (SC) during early postnatal development.
Regulation (alters) of Gene_expression (expression) of P2X in DRG associated with spinal cord
8) Confidence 0.02 Published 2008 Journal Auton Neurosci Section Abstract Doc Link 18541457 Disease Relevance 0.10 Pain Relevance 0.30
Increased expression of CGRP, SP, P2X(3), and TRPV1 in the TG may be involved in the behavioral changes in this model.
Regulation (involved) of Gene_expression (expression) of P2X associated with substance p and calcitonin gene-related peptide
9) Confidence 0.01 Published 2006 Journal J Pain Section Abstract Doc Link 16942952 Disease Relevance 1.56 Pain Relevance 1.39

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