INT105325

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.75
First Reported 2002
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 1.32
Pain Relevance 1.72

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (ENPP2) extracellular region (ENPP2) plasma membrane (ENPP2)
transcription factor binding (ENPP2)
Anatomy Link Frequency
plasma 1
sciatic nerve 1
spike 1
ENPP2 (Homo sapiens)
ENPP2 - H226Q (2)
Pain Link Frequency Relevance Heat
Inflammation 10 99.40 Very High Very High Very High
lidocaine 8 99.28 Very High Very High Very High
Sciatic nerve 2 96.12 Very High Very High Very High
Hyperalgesia 1 94.40 High High
Action potential 4 93.16 High High
Neuropathic pain 7 88.72 High High
Bioavailability 1 87.20 High High
local anesthetic 2 85.84 High High
tetrodotoxin 2 71.60 Quite High
cytokine 4 68.80 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 10 99.40 Very High Very High Very High
Hyperalgesia 1 94.40 High High
Neuropathic Pain 7 88.72 High High
Disease 9 72.72 Quite High
Demyelinating Disease 4 65.68 Quite High
Arthritis 1 64.72 Quite High
Cancer 13 64.28 Quite High
Calcification 46 60.72 Quite High
Adhesions 1 30.48 Quite Low
Metastasis 4 24.32 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
NPP2 (autotaxin, PD-1a), though very similar to NPP1 and NPP3 in structural organization (Figure 1), is synthesized as a pro-enzyme and further processed to be a secretory molecule (4.9).
Gene_expression (synthesized) of autotaxin
1) Confidence 0.75 Published 2006 Journal Purinergic Signal Section Body Doc Link PMC2254483 Disease Relevance 0.06 Pain Relevance 0
In the present study, the focal application of anemone toxin II (ATX, 300 nM), which slows Na-channel inactivation, produced prolonged depolarizing after-potentials and, coincidentally, induced spontaneous bursting impulse activity that propagated away from the site of ATX application in the frog sciatic nerve in vitro.
Gene_expression (produced) of ATX in sciatic nerve associated with sciatic nerve
2) Confidence 0.65 Published 2002 Journal Pain Section Abstract Doc Link 12237212 Disease Relevance 0.17 Pain Relevance 0.49
The application of low concentrations of lidocaine (1-10 microM), both at the site of ATX exposure and at a distant site, selectively and reversibly inhibited the spontaneous bursting, while having no effect on the electrically stimulated initial spike of the compound action potential.
Gene_expression (exposure) of ATX in spike associated with action potential and lidocaine
3) Confidence 0.65 Published 2002 Journal Pain Section Abstract Doc Link 12237212 Disease Relevance 0.15 Pain Relevance 0.67
Preparation and detection of Autotaxin Proteins
Gene_expression (detection) of Autotaxin
4) Confidence 0.64 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
Fig. 3B shows the relative hydrolytic activities of WT-ATX (30 ng ATX protein/reaction) and H226Q-ATX (360 ng ATX protein/reaction) as functions of FS-3 concentration, and Fig. 3C shows the relative hydrolytic activities of WT-ATX and H226Q-ATX (protein/reaction as in B) as functions of pNpTMP concentration.
Gene_expression (concentration) of H226Q-ATX (H226Q)
5) Confidence 0.49 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
Fig. 3B shows the relative hydrolytic activities of WT-ATX (30 ng ATX protein/reaction) and H226Q-ATX (360 ng ATX protein/reaction) as functions of FS-3 concentration, and Fig. 3C shows the relative hydrolytic activities of WT-ATX and H226Q-ATX (protein/reaction as in B) as functions of pNpTMP concentration.
Gene_expression (shows) of H226Q-ATX (H226Q)
6) Confidence 0.49 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0 Pain Relevance 0
The specific inhibitor PF-8380, dosed orally at 30 mg/kg, provided >95% reduction in both plasma and air pouch LPA within 3 h, indicating autotaxin is a major source of LPA during inflammation.
Gene_expression (source) of autotaxin in plasma associated with inflammation
7) Confidence 0.12 Published 2010 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 20392816 Disease Relevance 0.94 Pain Relevance 0.56

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox